PMID- 28657528
OWN - NLM
STAT- MEDLINE
DCOM- 20170726
LR  - 20170726
IS  - 1853-0605 (Electronic)
IS  - 0014-6722 (Linking)
VI  - 74
IP  - 2
DP  - 2017
TI  - IL-6, MMP 3 and prognosis in previously healthy sepsis patients.
PG  - 99-106
AB  - Sepsis and septic shock are clinical conditions with high mortality despite 
      advances in technology and are the leading cause of death in intensive care. 
      Clinical manifestations and morbidity may be attributable to a disproportionate 
      increase in proinflammatory cytokines. The aim of this study was to evaluate the 
      ability to predict mortality from interleukin 6 [IL-6] and matrix 
      metalloproteinase 3 [MMP-3]. This single-center, observational, prospective study 
      included 48 adult patients admitted to the Hospital Nacional de Clinicas in 
      Cordoba, Argentina, with sepsis or septic shock. Serum levels of IL-6 and MMP-3 
      were measured at the time of diagnosis and 72 hours later. At time of admission, 
      MMP-3 was 13.77 mg/ml in patients who died and 10.55 mg/ml in patients who 
      survived up to 28 days after hospitalization [p = 0.012], while IL-6 did not 
      differ between the groups. The change in IL-6 over 72 hours was increased in 
      nonsurvivors by 21.11 +/- 11.81 pg/ml and decreased in survivors by 40.87 +/- 14.94 
      pg/ml [p = 0.007]. No difference in the change of MMP-3 over 72 hours was 
      observed between survivors and nonsurvivors. This study shows that MMP-3 at 
      admission and the change in IL-6 over the first 72 hours of hospitalization could 
      provide prognostic information in septic patients. Further studies are needed to 
      define the utility of these cytokines as a measure of sepsis severity and as 
      predictors of mortality.
FAU - Ricarte-Bratti, Juan Pablo
AU  - Ricarte-Bratti JP
FAU - Brizuela, Nilda Y
AU  - Brizuela NY
FAU - Jaime-Albarran, Nicolas
AU  - Jaime-Albarran N
FAU - Montrull, Hilda L
AU  - Montrull HL
LA  - eng
PT  - Journal Article
PT  - Observational Study
TT  - IL-6, MMP-3 y pronostico en pacientes con sepsis previamente sanos.
PL  - Argentina
TA  - Rev Fac Cien Med Univ Nac Cordoba
JT  - Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina)
JID - 8303003
RN  - 0 (Biomarkers)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Female
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - Sepsis/*blood/*mortality
MH  - Shock, Septic/blood/mortality
MH  - Time Factors
EDAT- 2017/06/29 06:00
MHDA- 2017/07/27 06:00
CRDT- 2017/06/29 06:00
PHST- 2017/06/29 06:00 [entrez]
PHST- 2017/06/29 06:00 [pubmed]
PHST- 2017/07/27 06:00 [medline]
PST - ppublish
SO  - Rev Fac Cien Med Univ Nac Cordoba. 2017;74(2):99-106.