PMID- 28657863 OWN - NLM STAT- MEDLINE DCOM- 20180405 LR - 20180405 IS - 1466-447X (Electronic) IS - 0264-0414 (Linking) VI - 36 IP - 8 DP - 2018 Apr TI - Carbohydrate intake and training efficacy - a randomized cross-over study. PG - 942-948 LID - 10.1080/02640414.2017.1346276 [doi] AB - Carbohydrate (CHO) availability during endurance exercise seems to attenuate exercise-induced perturbations of cellular homeostasis and might consequently diminish the stimulus for training adaptation. Therefore, a negative effect of CHO intake on endurance training efficacy seems plausible. This study aimed to test the influence of carbohydrate intake on the efficacy of an endurance training program on previously untrained healthy adults. A randomized cross-over trial (8-week wash-out period) was conducted in 23 men and women with two 8-week training periods (with vs. without intake of 50g glucose before each training bout). Training intervention consisted of 4x45 min running/walking sessions/week at 70% of heart rate reserve. Exhaustive, ramp-shaped exercise tests with gas exchange measurements were conducted before and after each training period. Outcome measures were maximum oxygen uptake (VO(2max)) and ventilatory anaerobic threshold (VT). VO(2max) and VT increased after training regardless of CHO intake (VO(2max): Non-CHO 2.6 +/- 3.0 ml*min(-1)*kg(-1) p = 0.004; CHO 1.4 +/- 2.5 ml*min(-1)*kg(-1) p = 0.049; VT: Non-CHO 4.2 +/- 4.2 ml*min(-1)*kg(-1) p < 0.001; CHO 3.0 +/- 4.2 ml*min(-1)*kg(-1) p = 0.003). The 95% confidence interval (CI) for the difference between conditions was between +0.1 and +2.1 ml*min(-1)*kg(-1) for VO(2max) and between -1.2 and +3.1 for VT. It is concluded that carbohydrate intake could potentially impair the efficacy of an endurance training program. FAU - Beaudouin, Florian AU - Beaudouin F AD - a Institute of Sports and Preventive Medicine , Saarland University, Faculty of Clinical Medicine , Saarbrucken , Germany. FAU - Joerg, Frederic AU - Joerg F AD - a Institute of Sports and Preventive Medicine , Saarland University, Faculty of Clinical Medicine , Saarbrucken , Germany. FAU - Hilpert, Anette AU - Hilpert A AD - a Institute of Sports and Preventive Medicine , Saarland University, Faculty of Clinical Medicine , Saarbrucken , Germany. FAU - Meyer, Tim AU - Meyer T AD - a Institute of Sports and Preventive Medicine , Saarland University, Faculty of Clinical Medicine , Saarbrucken , Germany. FAU - Hecksteden, Anne AU - Hecksteden A AD - a Institute of Sports and Preventive Medicine , Saarland University, Faculty of Clinical Medicine , Saarbrucken , Germany. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20170628 PL - England TA - J Sports Sci JT - Journal of sports sciences JID - 8405364 RN - 0 (Blood Glucose) RN - 0 (Dietary Carbohydrates) SB - IM MH - Adaptation, Physiological MH - Adult MH - Anaerobic Threshold/physiology MH - Blood Glucose/metabolism MH - Cross-Over Studies MH - Dietary Carbohydrates/*administration & dosage MH - Exercise Test MH - Female MH - Heart Rate/physiology MH - Humans MH - Male MH - Middle Aged MH - Oxygen Consumption/physiology MH - *Physical Conditioning, Human MH - Physical Endurance/*physiology MH - Prospective Studies MH - Pulmonary Gas Exchange/physiology OTO - NOTNLM OT - Glucose monohydrate OT - aerobic exercise OT - maximum oxygen uptake OT - physiological adaptation EDAT- 2017/06/29 06:00 MHDA- 2018/04/06 06:00 CRDT- 2017/06/29 06:00 PHST- 2017/06/29 06:00 [pubmed] PHST- 2018/04/06 06:00 [medline] PHST- 2017/06/29 06:00 [entrez] AID - 10.1080/02640414.2017.1346276 [doi] PST - ppublish SO - J Sports Sci. 2018 Apr;36(8):942-948. doi: 10.1080/02640414.2017.1346276. Epub 2017 Jun 28.