PMID- 28658315
OWN - NLM
STAT- MEDLINE
DCOM- 20170922
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 6
DP  - 2017
TI  - Choroidal change in acute anterior uveitis associated with human leukocyte 
      antigen-B27.
PG  - e0180109
LID - 10.1371/journal.pone.0180109 [doi]
LID - e0180109
AB  - PURPOSE: To evaluate choroidal changes in eyes with acute anterior uveitis 
      associated with human leukocyte antigen (HLA)-B27. METHODS: In 44 patients with 
      first-onset, unilateral, acute-onset (<1 week) anterior uveitis for which 
      diagnostic work-ups revealed positivity only for HLA-B27, wide-field 
      three-dimensional volumetric raster scan using swept-source optical coherence 
      tomography was performed for both eyes. Choroidal thickness was measured by 
      automated segmentation and thickness mapping and compared between eyes with 
      uveitis and the fellow eyes at baseline. Choroidal thickness was compared before 
      and after topical and/or systemic corticosteroid therapy. Relative choroidal 
      thickening was defined as the choroidal thickness of the uveitic eye minus that 
      of the corresponding eye and correlated with the degree of intraocular 
      inflammation. RESULTS: Compared to the fellow eyes, eyes with acute anterior 
      uveitis showed significant choroidal thickening on the subfoveal and parafoveal 
      areas at baseline (all P <0.05). En face choroidal imaging showed dilation of 
      large choroidal vessels on the macula. Relative choroidal thickening 
      significantly correlated with the degree of anterior chamber inflammation at 
      baseline (correlation coefficient = 0.341, P = 0.023). After treating 
      inflammation, the choroid on the macula thinned significantly (from 262.1 +/- 66.5 
      to 239.5 +/- 61.0 mum in the subfoveal choroid, P<0.001). CONCLUSIONS: Eyes with 
      HLA-B27-associated anterior uveitis showed significant choroidal thickening at 
      acute phase that subsequently decreased after treatment, indicating subclinical 
      choroidal inflammation in the eyes. Choroidal thickness might indicate disease 
      activity in acute anterior uveitis associated with HLA-B27.
FAU - Ahn, Seong Joon
AU  - Ahn SJ
AD  - Department of Ophthalmology, Hanyang University Hospital, Seoul, Republic of 
      Korea.
FAU - Kim, Ji Hong
AU  - Kim JH
AD  - Department of Ophthalmology, Hanyang University Hospital, Seoul, Republic of 
      Korea.
FAU - Lee, Byung Ro
AU  - Lee BR
AD  - Department of Ophthalmology, Hanyang University Hospital, Seoul, Republic of 
      Korea.
LA  - eng
PT  - Journal Article
DEP - 20170628
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Choroid/diagnostic imaging/immunology/*pathology
MH  - Female
MH  - Fundus Oculi
MH  - HLA-B27 Antigen/*immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Uveitis, Anterior/diagnostic imaging/immunology/*pathology
MH  - Young Adult
PMC - PMC5489203
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/06/29 06:00
MHDA- 2017/09/25 06:00
PMCR- 2017/06/28
CRDT- 2017/06/29 06:00
PHST- 2017/02/15 00:00 [received]
PHST- 2017/06/11 00:00 [accepted]
PHST- 2017/06/29 06:00 [entrez]
PHST- 2017/06/29 06:00 [pubmed]
PHST- 2017/09/25 06:00 [medline]
PHST- 2017/06/28 00:00 [pmc-release]
AID - PONE-D-17-06247 [pii]
AID - 10.1371/journal.pone.0180109 [doi]
PST - epublish
SO  - PLoS One. 2017 Jun 28;12(6):e0180109. doi: 10.1371/journal.pone.0180109. 
      eCollection 2017.