PMID- 28658559
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20221207
IS  - 1600-065X (Electronic)
IS  - 0105-2896 (Linking)
VI  - 278
IP  - 1
DP  - 2017 Jul
TI  - Innate and adaptive type 2 immunity in lung allergic inflammation.
PG  - 162-172
LID - 10.1111/imr.12557 [doi]
AB  - Allergic inflammation is a type 2 immune disorder classically characterized by 
      high levels of immunoglobulin E (IgE) and the development of Th2 cells. Asthma is 
      a pulmonary allergic inflammatory disease resulting in bronchial 
      hyper-reactivity. Atopic asthma is defined by IgE antibody-mediated mast cell 
      degranulation, while in non-atopic asthma there is no allergen-specific IgE and 
      more involvement of innate immune cells, such as basophils, group 2 innate 
      lymphoid cells (ILC2), and eosinophils. Recently, protease allergens were shown 
      to cause asthmatic responses in the absence of Th2 cells, suggesting that an 
      innate cell network (IL-33/TSLP-basophil-ILC2-IL-5/IL-13 axis) can facilitate the 
      sensitization phase of type 2 inflammatory responses. Recent evidence also 
      indicates that in the chronic phase, these innate immune cells directly or 
      indirectly contribute to the adaptive Th2 cell responses. In this review, we 
      discuss the role of Th2 cytokines (IL-4 and IL-13) and innate immune cells (mast 
      cells, basophils, ILC2s, and dendritic cells) in the cross-talk between innate 
      and adaptive inflammatory responses.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Kubo, Masato
AU  - Kubo M
AUID- ORCID: 0000-0001-7867-3086
AD  - Division of Molecular Pathology, Research Institute for Biomedical Science, Tokyo 
      University of Science, Noda, Japan.
AD  - Laboratory for Cytokine Regulation, Research Center for Integrative Medical 
      Science (IMS), RIKEN Yokohama Institute, Yokohama, Kanagawa, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-33)
RN  - 207137-56-2 (Interleukin-4)
RN  - GT0IL38SP4 (Thymic Stromal Lymphopoietin)
SB  - IM
MH  - *Adaptive Immunity
MH  - Animals
MH  - Basophils/immunology/metabolism
MH  - Cytokines/metabolism
MH  - Dendritic Cells/immunology/metabolism
MH  - Humans
MH  - Hypersensitivity/*immunology/metabolism
MH  - *Immunity, Innate
MH  - Interleukin-33/metabolism
MH  - Interleukin-4/metabolism
MH  - Lymphocyte Activation/immunology
MH  - Lymphocyte Subsets/immunology/metabolism
MH  - Mast Cells/immunology/metabolism
MH  - Pneumonia/*immunology/metabolism
MH  - Th2 Cells/*immunology/metabolism
MH  - Thymic Stromal Lymphopoietin
OTO - NOTNLM
OT  - Allergy
OT  - Asthma
OT  - Cell Lineages and Subsets
OT  - Immune-mediated Diseases
OT  - Mast Cells/Basophils
OT  - Th1/Th2/Th17 Cells
OT  - Tissues
EDAT- 2017/06/29 06:00
MHDA- 2018/03/27 06:00
CRDT- 2017/06/29 06:00
PHST- 2017/06/29 06:00 [entrez]
PHST- 2017/06/29 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
AID - 10.1111/imr.12557 [doi]
PST - ppublish
SO  - Immunol Rev. 2017 Jul;278(1):162-172. doi: 10.1111/imr.12557.