PMID- 28659282
OWN - NLM
STAT- MEDLINE
DCOM- 20170822
LR  - 20181222
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 37
IP  - 30
DP  - 2017 Jul 26
TI  - Experience-Dependent Plasticity in Accessory Olfactory Bulb Interneurons 
      following Male-Male Social Interaction.
PG  - 7240-7252
LID - 10.1523/JNEUROSCI.1031-17.2017 [doi]
AB  - Chemosensory information processing in the mouse accessory olfactory system 
      guides the expression of social behavior. After salient chemosensory encounters, 
      the accessory olfactory bulb (AOB) experiences changes in the balance of 
      excitation and inhibition at reciprocal synapses between mitral cells (MCs) and 
      local interneurons. The mechanisms underlying these changes remain controversial. 
      Moreover, it remains unclear whether MC-interneuron plasticity is unique to 
      specific behaviors, such as mating, or whether it is a more general feature of 
      the AOB circuit. Here, we describe targeted electrophysiological studies of AOB 
      inhibitory internal granule cells (IGCs), many of which upregulate the 
      immediate-early gene Arc after male-male social experience. Following the 
      resident-intruder paradigm, Arc-expressing IGCs in acute AOB slices from resident 
      males displayed stronger excitation than nonexpressing neighbors when sensory 
      inputs were stimulated. The increased excitability of Arc-expressing IGCs was not 
      correlated with changes in the strength or number of excitatory synapses with MCs 
      but was instead associated with increased intrinsic excitability and decreased 
      HCN channel-mediated I(H) currents. Consistent with increased inhibition by IGCs, 
      MCs responded to sensory input stimulation with decreased depolarization and 
      spiking following resident-intruder encounters. These results reveal that 
      nonmating behaviors drive AOB inhibitory plasticity and indicate that increased 
      MC inhibition involves intrinsic excitability changes in Arc-expressing 
      interneurons.SIGNIFICANCE STATEMENT The accessory olfactory bulb (AOB) is a site 
      of experience-dependent plasticity between excitatory mitral cells (MCs) and 
      inhibitory internal granule cells (IGCs), but the physiological mechanisms and 
      behavioral conditions driving this plasticity remain unclear. Here, we report 
      studies of AOB neuronal plasticity following male-male social chemosensory 
      encounters. We show that the plasticity-associated immediate-early gene Arc is 
      selectively expressed in IGCs from resident males following the resident-intruder 
      assay. After behavior, Arc-expressing IGCs are more strongly excited by sensory 
      input stimulation and MC activation is suppressed. Arc-expressing IGCs do not 
      show increased excitatory synaptic drive but instead show increased intrinsic 
      excitability. These data indicate that MC-IGC plasticity is induced after 
      male-male social chemosensory encounters, resulting in enhanced MC suppression by 
      Arc-expressing IGCs.
CI  - Copyright (c) 2017 the authors 0270-6474/17/377240-13$15.00/0.
FAU - Cansler, Hillary L
AU  - Cansler HL
AUID- ORCID: 0000-0001-8267-0515
AD  - Department of Neuroscience, and.
AD  - Neuroscience Graduate Program, Graduate Program of Biomedical Sciences, The 
      University of Texas Southwestern Medical Center, Dallas, Texas 75390.
FAU - Maksimova, Marina A
AU  - Maksimova MA
AD  - Department of Neuroscience, and.
FAU - Meeks, Julian P
AU  - Meeks JP
AUID- ORCID: 0000-0002-7537-4491
AD  - Department of Neuroscience, and julian.meeks@utsouthwestern.edu.
LA  - eng
GR  - R00 DC011780/DC/NIDCD NIH HHS/United States
GR  - R01 DC015784/DC/NIDCD NIH HHS/United States
GR  - T32 DA007290/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20170628
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (activity regulated cytoskeletal-associated protein)
SB  - IM
MH  - Aggression/*physiology
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Cytoskeletal Proteins/metabolism
MH  - Interneurons/*physiology
MH  - Interpersonal Relations
MH  - Learning/*physiology
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Nerve Net/physiology
MH  - Nerve Tissue Proteins/metabolism
MH  - Neuronal Plasticity/*physiology
MH  - Olfactory Bulb/*physiology
MH  - *Social Behavior
MH  - Synaptic Transmission/physiology
PMC - PMC5546401
OTO - NOTNLM
OT  - accessory olfactory bulb
OT  - chemical senses
OT  - experience-dependent plasticity
OT  - interneuron
OT  - intrinsic excitability
OT  - sensory processing
COIS- The authors declare no competing financial interests.
EDAT- 2017/07/01 06:00
MHDA- 2017/08/23 06:00
PMCR- 2018/01/26
CRDT- 2017/06/30 06:00
PHST- 2017/04/17 00:00 [received]
PHST- 2017/06/01 00:00 [revised]
PHST- 2017/06/22 00:00 [accepted]
PHST- 2017/07/01 06:00 [pubmed]
PHST- 2017/08/23 06:00 [medline]
PHST- 2017/06/30 06:00 [entrez]
PHST- 2018/01/26 00:00 [pmc-release]
AID - JNEUROSCI.1031-17.2017 [pii]
AID - 1031-17 [pii]
AID - 10.1523/JNEUROSCI.1031-17.2017 [doi]
PST - ppublish
SO  - J Neurosci. 2017 Jul 26;37(30):7240-7252. doi: 10.1523/JNEUROSCI.1031-17.2017. 
      Epub 2017 Jun 28.