PMID- 28660533 OWN - NLM STAT- MEDLINE DCOM- 20190415 LR - 20190415 IS - 1435-1269 (Electronic) IS - 0948-6704 (Linking) VI - 51 IP - 2 DP - 2018 Feb TI - Analysis of cytopenia in geriatric inpatients. PG - 231-236 LID - 10.1007/s00391-017-1280-9 [doi] AB - BACKGROUND: Peripheral blood dyscrasias in older patients are repeatedly seen in geriatric clinical practice; however, there is substantial lack of data about the epidemiology, possible causes and treatment options in this patient group. Proton pump inhibitors (PPI) are extensively used in older patients and associated with leukopenia. The primary objective of this study was the assessment of encoded cytopenia prevalence in a geriatric patient cohort and the secondary objective was the assessment of putative causes and the analysis of PPI administration in patients with cytopenia. METHODS: Retrospective evaluation of patients admitted to the geriatric department of a German urban hospital between 2010 and 2012. Electronic patient data were screened for encoded diagnosis of cytopenia according to the International Classification of Diseases (ICD) 10. Inclusion criteria were ICD code D69.0-9 and/or D70.0-7, age >/=60 years and exclusion criteria were no ICD code D69.0-9 and/or D70.0-7 and age <60 years. Out of 9328 screened inpatients 54 patients remained for analysis. Study parameters included hemoglobin (Hb), red blood cell count (RBC), leucocytes, platelets, mean cell volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW), presence of leukopenia (<4000/microl), presence of thrombocytopenia (<140,000/microl) and presence of anemia according to the World Health Organization (WHO). Substitution of blood products, medication with PPI and potential causes for dyscrasias were evaluated based on electronic patient records. RESULTS: The mean age was 78.3 +/- 6.5 years (27 females, 27 males), anemia was seen in 78%, leukopenia was encoded in13% and thrombocytopenia in 44.4%. In most of the patients no substitution of blood products was documented. In most of the patients (20.4%) cytopenia was attributed to either heparin-induced thrombocytopenia (HIT) or hemato-oncologic (20.4%) diseases, followed by drug association in 18.5%. In 70.8% of the study patients PPIs were administered but the indication for PPI administration remained unclear in 20.4%. CONCLUSION: The results encourage accurate assessment of blood dyscrasias and appropriate documentation as well as indication check for PPI treatment in geriatric inpatients. FAU - Rohrig, G AU - Rohrig G AD - Ageing Clinical Research, Department II Internal Medicine, University Hospital Cologne, Cologne, Germany. gabriele.roehrig@uk-koeln.de. AD - Geriatric Department, St. Marien-Hospital, Kunibertskloster 11-13, 50668, Cologne, Germany. gabriele.roehrig@uk-koeln.de. FAU - Becker, I AU - Becker I AD - Institute for Medical Statistics, Informatics and Epidemiology, University Hospital Cologne, Cologne, Germany. FAU - Pappas, K AU - Pappas K AD - Ageing Clinical Research, Department II Internal Medicine, University Hospital Cologne, Cologne, Germany. AD - Geriatric Department, St. Marien-Hospital, Kunibertskloster 11-13, 50668, Cologne, Germany. FAU - Polidori, M C AU - Polidori MC AD - Ageing Clinical Research, Department II Internal Medicine, University Hospital Cologne, Cologne, Germany. FAU - Schulz, R J AU - Schulz RJ AD - Geriatric Department, St. Marien-Hospital, Kunibertskloster 11-13, 50668, Cologne, Germany. LA - eng PT - Journal Article TT - Analyse von Zytopenien bei stationar geriatrischen Patienten. DEP - 20170628 PL - Germany TA - Z Gerontol Geriatr JT - Zeitschrift fur Gerontologie und Geriatrie JID - 9506215 RN - 0 (Proton Pump Inhibitors) SB - IM MH - Aged MH - Aged, 80 and over MH - Anemia/chemically induced/*epidemiology MH - Cohort Studies MH - Cross-Sectional Studies MH - Erythrocyte Count MH - Erythrocyte Indices/drug effects MH - Female MH - Hemoglobinometry MH - Hospitals, Urban MH - Humans MH - Leukocyte Count MH - Leukopenia/chemically induced/*epidemiology MH - Male MH - Middle Aged MH - Platelet Count MH - Proton Pump Inhibitors/*adverse effects/therapeutic use MH - Retrospective Studies MH - Risk Factors MH - Thrombocytopenia/chemically induced/*epidemiology OTO - NOTNLM OT - Blood dyscrasias OT - Geriatrics OT - Proton pump inhibitors EDAT- 2017/07/01 06:00 MHDA- 2019/04/16 06:00 CRDT- 2017/06/30 06:00 PHST- 2016/09/26 00:00 [received] PHST- 2017/06/09 00:00 [accepted] PHST- 2017/07/01 06:00 [pubmed] PHST- 2019/04/16 06:00 [medline] PHST- 2017/06/30 06:00 [entrez] AID - 10.1007/s00391-017-1280-9 [pii] AID - 10.1007/s00391-017-1280-9 [doi] PST - ppublish SO - Z Gerontol Geriatr. 2018 Feb;51(2):231-236. doi: 10.1007/s00391-017-1280-9. Epub 2017 Jun 28.