PMID- 28660733
OWN - NLM
STAT- MEDLINE
DCOM- 20180521
LR  - 20220331
IS  - 1600-0404 (Electronic)
IS  - 0001-6314 (Linking)
VI  - 136
IP  - 6
DP  - 2017 Dec
TI  - Prospective measurement of quality of life in myotonic dystrophy type 1.
PG  - 694-697
LID - 10.1111/ane.12788 [doi]
AB  - INTRODUCTION: Generic patient reported outcome measures have had varied success 
      in tracking QoL in myotonic dystrophy type 1 (DM1). AIM: To analyze changes of 
      Individualized Neuromuscular Quality of Life questionnaire (INQoL) scores in 
      clinic patients with DM1 over a 6-year period. METHOD: Patients completed the 
      INQoL at baseline and after a 6-year period through their attendance in a 
      neurology outpatient clinic. Severity of muscular involvement in DM1 was analyzed 
      using the Muscular Impairment Rating Scale (MIRS). RESULTS: Ninety-nine DM1 
      patients completed a baseline visit. Sixty-seven of these patients were retested 
      at an interval time. The overall INQoL score improved in our sample of patients 
      (P<.05) as did the following subscales: myotonia (P<.05), pain (P<.05), 
      activities (P<.01), social relationships (P<.01), and body image (P<.05). No 
      changes were observed for the independence and emotions scales. There were no 
      differences in mean change of INQoL scores between patients with worsened MIRS 
      and those with no change in MIRS scale after follow-up (P>.05). CONCLUSION: 
      Individualized Neuromuscular Quality of Life questionnaire scores improved in our 
      cohort of DM1 patients during a 6-year period. INQoL score did not correlate with 
      progression of muscle weakness. This must be better understood before the 
      selection of the instrument for use in trials to measure therapeutic benefit in 
      DM1 patients.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Peric, S
AU  - Peric S
AUID- ORCID: 0000-0002-2979-556X
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
FAU - Heatwole, C
AU  - Heatwole C
AD  - University of Rochester Medical Center, Rochester, NY, USA.
FAU - Durovic, E
AU  - Durovic E
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
FAU - Kacar, A
AU  - Kacar A
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
FAU - Nikolic, A
AU  - Nikolic A
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
FAU - Basta, I
AU  - Basta I
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
FAU - Marjanovic, A
AU  - Marjanovic A
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
FAU - Stevic, Z
AU  - Stevic Z
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
FAU - Lavrnic, D
AU  - Lavrnic D
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
FAU - Rakocevic Stojanovic, V
AU  - Rakocevic Stojanovic V
AD  - Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of 
      Belgrade, Belgrade, Serbia.
LA  - eng
PT  - Journal Article
DEP - 20170628
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myotonic Dystrophy/pathology/*psychology
MH  - *Quality of Life
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - muscle weakness
OT  - myotonic dystrophy type 1
OT  - prospective study
OT  - quality of life
EDAT- 2017/07/01 06:00
MHDA- 2018/05/22 06:00
CRDT- 2017/06/30 06:00
PHST- 2017/05/23 00:00 [accepted]
PHST- 2017/07/01 06:00 [pubmed]
PHST- 2018/05/22 06:00 [medline]
PHST- 2017/06/30 06:00 [entrez]
AID - 10.1111/ane.12788 [doi]
PST - ppublish
SO  - Acta Neurol Scand. 2017 Dec;136(6):694-697. doi: 10.1111/ane.12788. Epub 2017 Jun 
      28.