PMID- 28662152
OWN - NLM
STAT- MEDLINE
DCOM- 20171006
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 6
DP  - 2017
TI  - Does external pneumatic compression treatment between bouts of overreaching 
      resistance training sessions exert differential effects on molecular signaling 
      and performance-related variables compared to passive recovery? An exploratory 
      study.
PG  - e0180429
LID - 10.1371/journal.pone.0180429 [doi]
LID - e0180429
AB  - PURPOSE: We sought to compare the effects of external pneumatic compression (EPC) 
      and sham when used concurrently with resistance training on performance-related 
      outcomes and molecular measures related to recovery. METHODS: Twenty (N = 20) 
      resistance-trained male participants (aged 21.6+/-2.4 years) were randomized to 
      balanced sham or EPC intervention groups. The protocol consisted of 3 consecutive 
      days of heavy, voluminous back squat exercise followed by EPC/sham treatment 
      (Days2-4) and 3 consecutive days of recovery (Days5-7) with EPC/sham only on 
      Days5-6. On Day1 (PRE), and Days3-7, venipuncture, flexibility and 
      pressure-to-pain threshold (PPT) measures were performed. Vastsus lateralis 
      muscle tissue was biopsied at PRE, 1-h post-EPC/sham treatment on Day2 (POST1) 
      and 24-h post-EPC/sham treatment on Day7 (POST2). Isokinetic peak torque was 
      assessed at PRE and POST2. RESULTS: Peak isokinetic strength did not change from 
      PRE to POST2 in either group. The PPT was significantly lower on Days3-6 with 
      sham, indicating greater muscle soreness, though this was largely abolished in 
      the EPC group. A significant decrease in flexibility with sham was observed on 
      Day3 (+16.2+/-4.6% knee joint angle; P<0.01) whereas there was no change with EPC 
      (+2.8+/-3.8%; P>0.01). Vastus lateralis poly-ubiquitinated proteins significantly 
      increased at the POST2 time point relative to PRE with sham (+66.6+/-24.6%; 
      P<0.025) and were significantly greater (P<0.025) than those observed with EPC at 
      the same time point (-18.6+/-8.5%). 4-hydroxynonenal values were significantly 
      lower at POST2 relative to PRE with EPC (-16.2+/-5.6%; P<0.025) and were 
      significantly lower (P<0.025) than those observed with sham at the same time 
      point (+11.8+/-5.9%). CONCLUSION: EPC mitigated a reduction in flexibility and PPT 
      that occurred with sham. Moreover, EPC reduced select skeletal muscle oxidative 
      stress and proteolysis markers during recovery from heavy resistance exercise.
FAU - Haun, Cody T
AU  - Haun CT
AD  - School of Kinesiology, Auburn University, Auburn, Alabama, United States of 
      America.
FAU - Roberts, Michael D
AU  - Roberts MD
AD  - School of Kinesiology, Auburn University, Auburn, Alabama, United States of 
      America.
AD  - Department of Cell Biology and Physiology, Edward Via College of Osteopathic 
      Medicine - Auburn Campus, Auburn, Alabama, United States of America.
FAU - Romero, Matthew A
AU  - Romero MA
AD  - School of Kinesiology, Auburn University, Auburn, Alabama, United States of 
      America.
FAU - Osburn, Shelby C
AU  - Osburn SC
AD  - School of Kinesiology, Auburn University, Auburn, Alabama, United States of 
      America.
FAU - Mobley, Christopher B
AU  - Mobley CB
AD  - School of Kinesiology, Auburn University, Auburn, Alabama, United States of 
      America.
FAU - Anderson, Richard G
AU  - Anderson RG
AD  - School of Kinesiology, Auburn University, Auburn, Alabama, United States of 
      America.
FAU - Goodlett, Michael D
AU  - Goodlett MD
AD  - Department of Cell Biology and Physiology, Edward Via College of Osteopathic 
      Medicine - Auburn Campus, Auburn, Alabama, United States of America.
AD  - Athletics Department, Auburn University, Auburn, Alabama, United States of 
      America.
FAU - Pascoe, David D
AU  - Pascoe DD
AD  - School of Kinesiology, Auburn University, Auburn, Alabama, United States of 
      America.
FAU - Martin, Jeffrey S
AU  - Martin JS
AUID- ORCID: 0000-0001-6762-086X
AD  - School of Kinesiology, Auburn University, Auburn, Alabama, United States of 
      America.
AD  - Department of Cell Biology and Physiology, Edward Via College of Osteopathic 
      Medicine - Auburn Campus, Auburn, Alabama, United States of America.
LA  - eng
PT  - Journal Article
DEP - 20170629
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Humans
MH  - Male
MH  - Resistance Training/*methods
MH  - *Signal Transduction
MH  - Young Adult
PMC - PMC5491247
COIS- Competing Interests: Partial reagent and participant compensation costs (50%) 
      were paid through a contract awarded to J.S.M. by Normatec (Newton Centre, MA, 
      USA). The funders did have a role in study design, but had no role in data 
      collection and analysis, decision to publish, or preparation of the manuscript. 
      This does not alter our adherence to PLOS ONE policies on sharing data and 
      materials. Moreover, none of the authors have conflicts of interest and/or 
      competing interests to disclose.
EDAT- 2017/07/01 06:00
MHDA- 2017/10/07 06:00
PMCR- 2017/06/29
CRDT- 2017/06/30 06:00
PHST- 2016/10/18 00:00 [received]
PHST- 2017/06/15 00:00 [accepted]
PHST- 2017/06/30 06:00 [entrez]
PHST- 2017/07/01 06:00 [pubmed]
PHST- 2017/10/07 06:00 [medline]
PHST- 2017/06/29 00:00 [pmc-release]
AID - PONE-D-16-41601 [pii]
AID - 10.1371/journal.pone.0180429 [doi]
PST - epublish
SO  - PLoS One. 2017 Jun 29;12(6):e0180429. doi: 10.1371/journal.pone.0180429. 
      eCollection 2017.