PMID- 28662161
OWN - NLM
STAT- MEDLINE
DCOM- 20171002
LR  - 20190208
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 6
DP  - 2017
TI  - Absence of EEG correlates of self-referential processing depth in ALS.
PG  - e0180136
LID - 10.1371/journal.pone.0180136 [doi]
LID - e0180136
AB  - Self-referential processing is a key cognitive process, associated with the 
      serotonergic system and the default mode network (DMN). Decreased levels of 
      serotonin and reduced activations of the DMN observed in amyotrophic lateral 
      sclerosis (ALS) suggest that self-referential processing might be altered in 
      patients with ALS. Here, we investigate the effects of ALS on the 
      electroencephalography correlates of self-referential thinking. We find that 
      electroencephalography (EEG) correlates of self-referential thinking are present 
      in healthy individuals, but not in those with ALS. In particular, thinking about 
      themselves or others significantly modulates the bandpower in the medial 
      prefrontal cortex in healthy individuals, but not in ALS patients. This finding 
      supports the view of ALS as a complex multisystem disorder which, as shown here, 
      includes dysfunctional processing of the medial prefrontal cortex. It points 
      towards possible alterations of self-consciousness in ALS patients, which might 
      have important consequences for patients' self-conceptions, personal relations, 
      and decision-making.
FAU - Fomina, Tatiana
AU  - Fomina T
AUID- ORCID: 0000-0002-0349-2077
AD  - Department of Empirical Inference, Max Planck Institute for Intelligent Systems, 
      Tubingen, Germany.
AD  - International Max Planck Research School for Cognitive and Systems Neuroscience, 
      University of Tubingen, Tubingen, Germany.
FAU - Weichwald, Sebastian
AU  - Weichwald S
AD  - Department of Empirical Inference, Max Planck Institute for Intelligent Systems, 
      Tubingen, Germany.
FAU - Synofzik, Matthis
AU  - Synofzik M
AD  - Department of Neurology, University of Tubingen, Tubingen, Germany.
AD  - German Center of Neurodegenerative Diseases (DZNE), Tubingen, Germany.
AD  - Hertie Institute for Clinical Brain Research, Tubingen, Germany.
FAU - Just, Jenifer
AU  - Just J
AD  - Department of Neurology, University of Tubingen, Tubingen, Germany.
AD  - German Center of Neurodegenerative Diseases (DZNE), Tubingen, Germany.
AD  - Hertie Institute for Clinical Brain Research, Tubingen, Germany.
FAU - Schols, Ludger
AU  - Schols L
AD  - Department of Neurology, University of Tubingen, Tubingen, Germany.
AD  - German Center of Neurodegenerative Diseases (DZNE), Tubingen, Germany.
AD  - Hertie Institute for Clinical Brain Research, Tubingen, Germany.
FAU - Scholkopf, Bernhard
AU  - Scholkopf B
AD  - Department of Empirical Inference, Max Planck Institute for Intelligent Systems, 
      Tubingen, Germany.
FAU - Grosse-Wentrup, Moritz
AU  - Grosse-Wentrup M
AD  - Department of Empirical Inference, Max Planck Institute for Intelligent Systems, 
      Tubingen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20170629
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Amyotrophic Lateral Sclerosis/diagnostic imaging/*physiopathology
MH  - Brain/diagnostic imaging
MH  - *Electroencephalography
MH  - Humans
PMC - PMC5491131
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/07/01 06:00
MHDA- 2017/10/03 06:00
PMCR- 2017/06/29
CRDT- 2017/06/30 06:00
PHST- 2017/01/22 00:00 [received]
PHST- 2017/06/09 00:00 [accepted]
PHST- 2017/06/30 06:00 [entrez]
PHST- 2017/07/01 06:00 [pubmed]
PHST- 2017/10/03 06:00 [medline]
PHST- 2017/06/29 00:00 [pmc-release]
AID - PONE-D-17-02919 [pii]
AID - 10.1371/journal.pone.0180136 [doi]
PST - epublish
SO  - PLoS One. 2017 Jun 29;12(6):e0180136. doi: 10.1371/journal.pone.0180136. 
      eCollection 2017.