PMID- 28663110
OWN - NLM
STAT- MEDLINE
DCOM- 20180501
LR  - 20180501
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 179
DP  - 2017 Oct 1
TI  - Sucrose and naltrexone prevent increased pain sensitivity and impaired long-term 
      memory induced by repetitive neonatal noxious stimulation: Role of BDNF and 
      beta-endorphin.
PG  - 213-219
LID - S0031-9384(17)30186-5 [pii]
LID - 10.1016/j.physbeh.2017.06.015 [doi]
AB  - Pain in neonates is associated with short and long-term adverse outcomes. Data 
      demonstrated that long-term consequences of untreated pain are linked to the 
      plasticity of the neonate's brain. Sucrose is effective and safe for reducing 
      painful procedures from single events. However, the mechanism of sucrose-induced 
      analgesia is not fully understood. The role of the opioid system in this 
      analgesia using the opioid receptor antagonist Naltrexone was investigated, plus 
      the long-term effects on learning and memory formation during adulthood. Pain was 
      induced in rat pups via needle pricks of the paws. Sucrose solution and/or 
      naltrexone were administered before the pricks. All treatments started on day one 
      of birth and continued for two weeks. At the end of 8weeks, behavioral studies 
      were conducted to test spatial learning and memory using radial arm water maze 
      (RAWM), and pain threshold via foot-withdrawal response to a hot plate. The 
      hippocampus was dissected; levels of brain derived neurotrophic factor (BDNF) and 
      endorphins were assessed using ELISA. Acute repetitive neonatal pain increased 
      pain sensitivity later in life, while naltrexone with sucrose decreased pain 
      sensitivity. Naltrexone and/or sucrose prevented neonatal pain induced impairment 
      of long-term memory, while neonatal pain decreased levels of BDNF in the 
      hippocampus; this decrease was averted by sucrose and naltrexone. Sucrose with 
      naltrexone significantly increased beta-endorphin levels in noxiously stimulated 
      rats. In conclusion, naltrexone and sucrose can reverse increased pain 
      sensitivity and impaired long-term memory induced by acute repetitive neonatal 
      pain probably by normalizing BDNF expression and increasing beta-endorphin levels.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Nuseir, Khawla Q
AU  - Nuseir KQ
AD  - Department of clinical pharmacy, Faculty of Pharmacy, Jordan University of 
      Science and Technology, Irbid, Jordan. Electronic address: kqnuseir@just.edu.jo.
FAU - Alzoubi, Karem H
AU  - Alzoubi KH
AD  - Department of clinical pharmacy, Faculty of Pharmacy, Jordan University of 
      Science and Technology, Irbid, Jordan.
FAU - Alhusban, Ahmed
AU  - Alhusban A
AD  - Department of clinical pharmacy, Faculty of Pharmacy, Jordan University of 
      Science and Technology, Irbid, Jordan.
FAU - Bawaane, Areej
AU  - Bawaane A
AD  - Department of clinical pharmacy, Faculty of Pharmacy, Jordan University of 
      Science and Technology, Irbid, Jordan.
FAU - Al-Azzani, Mohammed
AU  - Al-Azzani M
AD  - Department of clinical pharmacy, Faculty of Pharmacy, Jordan University of 
      Science and Technology, Irbid, Jordan.
FAU - Khabour, Omar F
AU  - Khabour OF
AD  - Department of medical laboratory sciences, Faculty of Applied Medical Sciences, 
      Jordan University of Science and Technology, Irbid, Jordan.
LA  - eng
PT  - Journal Article
DEP - 20170627
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dietary Sucrose)
RN  - 0 (Narcotic Antagonists)
RN  - 5S6W795CQM (Naltrexone)
RN  - 60617-12-1 (beta-Endorphin)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Dietary Sucrose/*administration & dosage
MH  - Hippocampus/drug effects/*growth & development/metabolism
MH  - Male
MH  - Maze Learning/drug effects/physiology
MH  - Memory, Long-Term/drug effects/physiology
MH  - Naltrexone/*pharmacology
MH  - Narcotic Antagonists/*pharmacology
MH  - Pain/*metabolism/psychology
MH  - *Pain Management
MH  - Pain Threshold/drug effects/physiology
MH  - Random Allocation
MH  - Rats, Wistar
MH  - Spatial Memory/drug effects/physiology
MH  - beta-Endorphin/metabolism
OTO - NOTNLM
OT  - BDNF
OT  - Cognition
OT  - Endorphins
OT  - Hippocampus
OT  - Memory
OT  - Pain
OT  - Sucrose
EDAT- 2017/07/01 06:00
MHDA- 2018/05/02 06:00
CRDT- 2017/07/01 06:00
PHST- 2017/01/04 00:00 [received]
PHST- 2017/06/13 00:00 [revised]
PHST- 2017/06/25 00:00 [accepted]
PHST- 2017/07/01 06:00 [pubmed]
PHST- 2018/05/02 06:00 [medline]
PHST- 2017/07/01 06:00 [entrez]
AID - S0031-9384(17)30186-5 [pii]
AID - 10.1016/j.physbeh.2017.06.015 [doi]
PST - ppublish
SO  - Physiol Behav. 2017 Oct 1;179:213-219. doi: 10.1016/j.physbeh.2017.06.015. Epub 
      2017 Jun 27.