PMID- 28663126
OWN - NLM
STAT- MEDLINE
DCOM- 20180117
LR  - 20180117
IS  - 1095-9947 (Electronic)
IS  - 1050-4648 (Linking)
VI  - 67
DP  - 2017 Aug
TI  - Ameliorative effect of vitamin E on hepatic oxidative stress and hypoimmunity 
      induced by high-fat diet in turbot (Scophthalmus maximus).
PG  - 634-642
LID - S1050-4648(17)30379-0 [pii]
LID - 10.1016/j.fsi.2017.06.056 [doi]
AB  - This study was conducted to examine the effects of vitamin E on growth 
      performance, oxidative stress and non-specific immunity of turbot (Scophthalmus 
      maximus) fed with high-fat diet. Results showed that high-fat diet significantly 
      increased hepatosomatic index, viscerosomatic index, hepatic malondialdehyde 
      level and decreased catalase and superoxide dismutase activities, whereas final 
      weight, specific growth rate and survival rate remained unchanged. Meanwhile, 
      nitro blue tetrazolium positive leucocytes of head kidney, respiratory burst 
      activity in head-kidney macrophage, phagocytic index and serum lysozyme activity 
      were significantly reduced after feeding with high-fat diet. Furthermore, fish 
      fed with high-fat diet promoted higher expression of heat shock protein (hsp70, 
      hsp90), and inhibited expression of complement component 3 (c3) in the liver and 
      tumor necrosis factor-alpha (tnf-alpha), interleukine 1beta (il-1beta), toll like receptor 22 
      (tlr-22) in the spleen and head-kidney, respectively. However, simultaneous 
      supplementation with 480 mg kg(-1) vitamin E protected turbot against high-fat 
      diet-induced hepatic oxidative stress, hypoimmunity through attenuating lipid 
      peroxidation, renewing antioxidant enzymes activities and nonspecific immune 
      responses, and modulating the expression of stress protein (hsp70, hsp90) and 
      immune-related genes (c3, tnf-alpha, il-1beta, tlr-22). In conclusion, the obtained 
      results indicate the vitamin E as a wildly used functional feed additive 
      contributes potentially to alleviate high-fat diet-induced hepatic oxidative 
      stress and hypoimmunity, maintain the health, and improve the broodstock 
      management for turbot.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Jia, Yudong
AU  - Jia Y
AD  - Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, 
      Qingdao Key Laboratory for Marine Fish Breeding and Biotechnology, Qingdao 
      266071, China. Electronic address: ydjia2011@hotmail.com.
FAU - Jing, Qiqi
AU  - Jing Q
AD  - College of Animal Science and Veterinary Medicine, Shandong Agricultural 
      University, Taian 271018, China.
FAU - Niu, Huaxin
AU  - Niu H
AD  - School of Animal Science and Technology, Inner Mongolia University for the 
      Nationalities, Tongliao 028042, China.
FAU - Huang, Bin
AU  - Huang B
AD  - Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, 
      Qingdao Key Laboratory for Marine Fish Breeding and Biotechnology, Qingdao 
      266071, China. Electronic address: huangbin@ysfri.ac.cn.
LA  - eng
PT  - Journal Article
DEP - 20170627
PL  - England
TA  - Fish Shellfish Immunol
JT  - Fish & shellfish immunology
JID - 9505220
RN  - 0 (Fish Proteins)
RN  - 0 (Vitamins)
RN  - 1406-18-4 (Vitamin E)
SB  - IM
MH  - Animal Feed/analysis
MH  - Animals
MH  - Diet/veterinary
MH  - Diet, High-Fat/*veterinary
MH  - Dietary Supplements/analysis
MH  - Dose-Response Relationship, Drug
MH  - Fish Proteins/metabolism
MH  - Flatfishes/*immunology/*metabolism
MH  - Gene Expression
MH  - *Immunity, Innate
MH  - Liver/physiopathology
MH  - *Oxidative Stress
MH  - Random Allocation
MH  - Vitamin E/*administration & dosage
MH  - Vitamins/administration & dosage
OTO - NOTNLM
OT  - Growth
OT  - High-fat diet
OT  - Nonspecific immunity
OT  - Oxidative stress
OT  - Turbot
OT  - Vitamin E
EDAT- 2017/07/01 06:00
MHDA- 2018/01/18 06:00
CRDT- 2017/07/01 06:00
PHST- 2017/01/02 00:00 [received]
PHST- 2017/06/13 00:00 [revised]
PHST- 2017/06/25 00:00 [accepted]
PHST- 2017/07/01 06:00 [pubmed]
PHST- 2018/01/18 06:00 [medline]
PHST- 2017/07/01 06:00 [entrez]
AID - S1050-4648(17)30379-0 [pii]
AID - 10.1016/j.fsi.2017.06.056 [doi]
PST - ppublish
SO  - Fish Shellfish Immunol. 2017 Aug;67:634-642. doi: 10.1016/j.fsi.2017.06.056. Epub 
      2017 Jun 27.