PMID- 28665074
OWN - NLM
STAT- MEDLINE
DCOM- 20180404
LR  - 20181113
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 32
IP  - 8
DP  - 2017 Aug
TI  - Clinical Features of Atopic Dermatitis in Adults Are Different according to 
      Onset.
PG  - 1360-1366
LID - 10.3346/jkms.2017.32.8.1360 [doi]
AB  - Few studies of atopic dermatitis (AD) in adult patients have evaluated 
      differences in clinical features of AD according to onset age. We aimed to 
      characterize the clinical features of AD in adult patients according to age of 
      onset. Subjects with AD outpatient visiting the Department of Dermatology at 
      Kangnam Sacred Heart Hospital were recruited for this study. A dermatologist 
      conducted clinical evaluation, a survey of demographics, and onset of 
      AD-associated signs and symptoms for each participant. Total immunoglobulin E 
      (IgE) was also tested. A total of 280 adult AD patients were enrolled, among 
      which 232 patients (82.86%) showed pre-adult-onset (age < 18 years) and 48 
      patients (17.14%) had adult-onset (age >/= 18 years) of AD. There were significant 
      differences between the 2 groups in the area of initial involvement (P = 0.017) 
      and in treatment history (P = 0.010). Interestingly, patients with body mass 
      index (BMI) >/= 25 showed significantly higher Eczema Area and Severity Index 
      (EASI) scores than did patients with BMI < 25 in the pre-adult-onset adult AD 
      group (P = 0.048). On the other hand, there were no significant differences in 
      sex, family history, BMI, EASI, and total IgE between patients with 
      pre-adult-onset AD and patients with adult-onset AD. Our findings suggest that, 
      even though many common features exist, there are significant differences between 
      the clinical characteristics of pre-adult-onset and adult-onset AD subgroups, in 
      adult patients with AD.
CI  - (c) 2017 The Korean Academy of Medical Sciences.
FAU - Son, Jee Hee
AU  - Son JH
AUID- ORCID: 0000-0002-7816-1942
AD  - Department of Dermatology, Hallym University Kangnam Sacred Heart Hospital, 
      Hallym University College of Medicine, Seoul, Korea.
FAU - Chung, Bo Young
AU  - Chung BY
AUID- ORCID: 0000-0002-2795-0140
AD  - Department of Dermatology, Hallym University Kangnam Sacred Heart Hospital, 
      Hallym University College of Medicine, Seoul, Korea.
FAU - Kim, Hye One
AU  - Kim HO
AUID- ORCID: 0000-0001-5846-0008
AD  - Department of Dermatology, Hallym University Kangnam Sacred Heart Hospital, 
      Hallym University College of Medicine, Seoul, Korea.
FAU - Park, Chun Wook
AU  - Park CW
AUID- ORCID: 0000-0003-4512-8668
AD  - Department of Dermatology, Hallym University Kangnam Sacred Heart Hospital, 
      Hallym University College of Medicine, Seoul, Korea. dermap@hanmail.net.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Body Mass Index
MH  - Dermatitis, Atopic/*diagnosis/pathology
MH  - Eczema/pathology
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Middle Aged
MH  - Severity of Illness Index
MH  - Young Adult
PMC - PMC5494337
OTO - NOTNLM
OT  - Age of Onset
OT  - Atopic Dermatitis
OT  - Clinical Feature
COIS- The authors have no potential conflicts of interest to disclose.
EDAT- 2017/07/01 06:00
MHDA- 2018/04/05 06:00
PMCR- 2017/08/01
CRDT- 2017/07/01 06:00
PHST- 2017/03/31 00:00 [received]
PHST- 2017/05/20 00:00 [accepted]
PHST- 2017/07/01 06:00 [entrez]
PHST- 2017/07/01 06:00 [pubmed]
PHST- 2018/04/05 06:00 [medline]
PHST- 2017/08/01 00:00 [pmc-release]
AID - 32.1360 [pii]
AID - 10.3346/jkms.2017.32.8.1360 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2017 Aug;32(8):1360-1366. doi: 10.3346/jkms.2017.32.8.1360.