PMID- 28665276
OWN - NLM
STAT- MEDLINE
DCOM- 20170907
LR  - 20191113
IS  - 1732-2693 (Electronic)
IS  - 0032-5449 (Linking)
VI  - 71
IP  - 0
DP  - 2017 Jun 8
TI  - Mitochondria: Target organelles for estrogen action.
PG  - 454-465
AB  - Estrogens belong to a group of sex hormones, which have been shown to act in 
      multidirectional way. Estrogenic effects are mediated by two types of 
      intracellular receptors: estrogen receptor 1 (ESR1) and estrogen receptor 2 
      (ESR2). There are two basic mechanisms of estrogen action: 1) classical-genomic, 
      in which the ligand-receptor complex acts as a transcriptional factor and 2) a 
      nongenomic one, which is still not fully understood, but has been seen to lead to 
      distinct biological effects, depending on tissue and ligand type. It is 
      postulated that nongenomic effects may be associated with membrane signaling and 
      the presence of classical nuclear receptors within the cell membrane. Estrogens 
      act in a multidirectional way also within cell organelles. It is assumed that 
      there is a mechanism which manages the migration of ESR into the mitochondrial 
      membrane, wherein the exogenous estrogen affect the morphology of mitochondria. 
      Estrogen, through its receptor, can directly modulate mitochondrial gene 
      expression. Moreover, by regulating the level of reactive oxygen species, 
      estrogens affect the biology of mitochondria. The considerations presented in 
      this paper indicate the pleiotropic effects of estrogens, which represent a 
      multidirectional pathway of signal transduction.
FAU - Chmielewska, Malgorzata
AU  - Chmielewska M
AD  - Katedra i Zaklad Biologii Komorki, Uniwersytet Medyczny im. Karola 
      Marcinkowskiego w Poznaniu.
FAU - Skibinska, Izabela
AU  - Skibinska I
AD  - Katedra i Zaklad Biologii Komorki, Uniwersytet Medyczny im. Karola 
      Marcinkowskiego w Poznaniu.
FAU - Kotwicka, Malgorzata
AU  - Kotwicka M
AD  - Katedra i Zaklad Biologii Komorki, Uniwersytet Medyczny im. Karola 
      Marcinkowskiego w Poznaniu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170608
PL  - Poland
TA  - Postepy Hig Med Dosw (Online)
JT  - Postepy higieny i medycyny doswiadczalnej (Online)
JID - 101206517
RN  - 0 (Estrogens)
RN  - 0 (Receptors, Estrogen)
SB  - IM
MH  - Animals
MH  - *Estrogens
MH  - Humans
MH  - Mitochondria/*metabolism/physiology
MH  - *Receptors, Estrogen
MH  - *Signal Transduction
EDAT- 2017/07/01 06:00
MHDA- 2017/09/08 06:00
CRDT- 2017/07/01 06:00
PHST- 2017/07/01 06:00 [entrez]
PHST- 2017/07/01 06:00 [pubmed]
PHST- 2017/09/08 06:00 [medline]
AID - 1239871 [pii]
AID - 10.5604/01.3001.0010.3828 [doi]
PST - epublish
SO  - Postepy Hig Med Dosw (Online). 2017 Jun 8;71(0):454-465. doi: 
      10.5604/01.3001.0010.3828.