PMID- 28666326
OWN - NLM
STAT- MEDLINE
DCOM- 20190121
LR  - 20190121
IS  - 1460-2377 (Electronic)
IS  - 0953-8178 (Linking)
VI  - 29
IP  - 11
DP  - 2017 Dec 30
TI  - IVIG-mediated effector functions in autoimmune and inflammatory diseases.
PG  - 491-498
LID - 10.1093/intimm/dxx039 [doi]
AB  - Intravenous immunoglobulin (IVIG) is a pooled preparation of normal IgG obtained 
      from several thousand healthy donors. It is widely used in the immunotherapy of a 
      large number of autoimmune and inflammatory diseases. The mechanisms of action of 
      IVIG are complex and, as discussed in this review, experimental and clinical data 
      provide an indicator that the therapeutic benefit of IVIG therapy is due to 
      several mutually non-exclusive mechanisms affecting soluble mediators as well as 
      cellular components of the immune system. These mechanisms depend on Fc and/or 
      F(ab')2 fragments. A better understanding of the effector functions of IVIG 
      should help in identification of biomarkers of responses to IVIG in autoimmune 
      patients.
CI  - (c) The Japanese Society for Immunology. 2017. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Galeotti, Caroline
AU  - Galeotti C
AD  - Institut National de la Sante et de la Recherche Medicale Unite, France.
AD  - Sorbonne Universites, UPMC Univ Paris 06, Paris, France.
AD  - Centre de Recherche des Cordeliers, Equipe -Immunopathologie et 
      Immunointervention Therapeutique, Paris, France.
AD  - Department of Pediatric Rheumatology, National Referral Centre of 
      Auto-inflammatory Diseases, CHU de Bicetre, France.
FAU - Kaveri, Srini V
AU  - Kaveri SV
AD  - Institut National de la Sante et de la Recherche Medicale Unite, France.
AD  - Sorbonne Universites, UPMC Univ Paris 06, Paris, France.
AD  - Centre de Recherche des Cordeliers, Equipe -Immunopathologie et 
      Immunointervention Therapeutique, Paris, France.
AD  - Universite Paris Descartes, Sorbonne Paris Cite, France.
FAU - Bayry, Jagadeesh
AU  - Bayry J
AD  - Institut National de la Sante et de la Recherche Medicale Unite, France.
AD  - Sorbonne Universites, UPMC Univ Paris 06, Paris, France.
AD  - Centre de Recherche des Cordeliers, Equipe -Immunopathologie et 
      Immunointervention Therapeutique, Paris, France.
AD  - Universite Paris Descartes, Sorbonne Paris Cite, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Int Immunol
JT  - International immunology
JID - 8916182
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Autoimmune Diseases/*immunology/*therapy
MH  - Humans
MH  - Immunoglobulins, Intravenous/*immunology/*therapeutic use
MH  - Inflammation/*immunology/*therapy
OTO - NOTNLM
OT  - B cell
OT  - autoimmunity
OT  - dendritic cell
OT  - granulocyte
OT  - sialylation
EDAT- 2017/07/02 06:00
MHDA- 2019/01/22 06:00
CRDT- 2017/07/02 06:00
PHST- 2017/05/04 00:00 [received]
PHST- 2017/06/27 00:00 [accepted]
PHST- 2017/07/02 06:00 [pubmed]
PHST- 2019/01/22 06:00 [medline]
PHST- 2017/07/02 06:00 [entrez]
AID - 3897037 [pii]
AID - 10.1093/intimm/dxx039 [doi]
PST - ppublish
SO  - Int Immunol. 2017 Dec 30;29(11):491-498. doi: 10.1093/intimm/dxx039.