PMID- 28670159
OWN - NLM
STAT- MEDLINE
DCOM- 20171010
LR  - 20181202
IS  - 2005-8330 (Electronic)
IS  - 1229-6929 (Print)
IS  - 1229-6929 (Linking)
VI  - 18
IP  - 4
DP  - 2017 Jul-Aug
TI  - Predictive Value of Cardiac Magnetic Resonance Imaging-Derived Myocardial Strain 
      for Poor Outcomes in Patients with Acute Myocarditis.
PG  - 643-654
LID - 10.3348/kjr.2017.18.4.643 [doi]
AB  - OBJECTIVE: To evaluate the utility of cardiovascular magnetic resonance 
      (CMR)-derived myocardial strain measurement for the prediction of poor outcomes 
      in patients with acute myocarditis. MATERIALS AND METHODS: We retrospectively 
      analyzed data from 37 patients with acute myocarditis who underwent CMR. Left 
      ventricular (LV) size, LV mass index, ejection fraction and presence of 
      myocardial late gadolinium enhancement (LGE) were analyzed. LV circumferential 
      strain (Ecc(SAX)), radial strain (Err(SAX)) from mid-ventricular level short-axis 
      cine views and LV longitudinal strain (Ell(LV)), radial strain (Err(Lax)) 
      measurements from 2-chamber long-axis views were obtained. In total, 31 of 37 
      patients (83.8%) underwent follow-up echocardiography. The primary outcome was 
      major adverse cardiovascular event (MACE). Incomplete LV functional recovery was 
      a secondary outcome. RESULTS: During an average follow-up of 41 months, 11 of 37 
      patients (29.7%) experienced MACE. Multivariable Cox proportional hazard 
      regression analysis, which included LV mass index, LV ejection fraction, the 
      presence of LGE, Ecc(SAX), Err(SAX), Ell(LV), and Err(Lax) values, indicated that 
      the presence of LGE (hazard ratio, 42.88; p = 0.014), together with ErrLax 
      (hazard ratio, 0.77 per 1%, p = 0.004), was a significant predictor of MACE. 
      Kaplan-Meier analysis demonstrated worse outcomes in patient with LGE and an 
      Err(Lax) value </= 9.48%. Multivariable backward regression analysis revealed that 
      Err(Lax) values were the only significant predictors of LV functional recovery 
      (hazard ratio, 0.54 per 1%; p = 0.042). CONCLUSION: CMR-derived Err(Lax) values 
      can predict poor outcomes, both MACE and incomplete LV functional recovery, in 
      patients with acute myocarditis, while LGE is only a predictor of MACE.
FAU - Lee, Ji Won
AU  - Lee JW
AD  - Department of Radiology, Pusan National University School of Medicine and Medical 
      Research Institute, Pusan National University Hospital, Busan 49241, Korea.
FAU - Jeong, Yeon Joo
AU  - Jeong YJ
AD  - Department of Radiology, Pusan National University School of Medicine and Medical 
      Research Institute, Pusan National University Hospital, Busan 49241, Korea.
FAU - Lee, Geewon
AU  - Lee G
AD  - Department of Radiology, Pusan National University School of Medicine and Medical 
      Research Institute, Pusan National University Hospital, Busan 49241, Korea.
FAU - Lee, Nam Kyung
AU  - Lee NK
AD  - Department of Radiology, Pusan National University School of Medicine and Medical 
      Research Institute, Pusan National University Hospital, Busan 49241, Korea.
FAU - Lee, Hye Won
AU  - Lee HW
AD  - Department of Cardiology, Pusan National University School of Medicine and 
      Medical Research Institute, Pusan National University Hospital, Busan 49241, 
      Korea.
FAU - Kim, Jin You
AU  - Kim JY
AD  - Department of Radiology, Pusan National University School of Medicine and Medical 
      Research Institute, Pusan National University Hospital, Busan 49241, Korea.
FAU - Choi, Bum-Sung
AU  - Choi BS
AD  - Pusan National University School of Medicine and Medical Research Institute, 
      Pusan National University Yangsan Hospital, Yangsan 50612, Korea.
FAU - Choo, Ki Seok
AU  - Choo KS
AD  - Department of Radiology, Pusan National University School of Medicine and Medical 
      Research Institute, Pusan National University Yangsan Hospital, Yangsan 50612, 
      Korea.
LA  - eng
PT  - Journal Article
DEP - 20170519
PL  - Korea (South)
TA  - Korean J Radiol
JT  - Korean journal of radiology
JID - 100956096
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
CIN - Korean J Radiol. 2018 Mar-Apr;19(2):366-367. PMID: 29520196
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Area Under Curve
MH  - Disease Progression
MH  - Echocardiography
MH  - Female
MH  - Gadolinium/chemistry
MH  - Heart Ventricles/diagnostic imaging
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocarditis/*diagnostic imaging/mortality/pathology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Ventricular Function, Left
PMC - PMC5447640
OTO - NOTNLM
OT  - Left ventricle
OT  - Magnetic resonance imaging
OT  - Major adverse cardiovascular events
OT  - Myocarditis
OT  - Strain
OT  - Ventricular dysfunction
EDAT- 2017/07/04 06:00
MHDA- 2017/10/11 06:00
PMCR- 2017/07/01
CRDT- 2017/07/04 06:00
PHST- 2016/03/09 00:00 [received]
PHST- 2016/11/08 00:00 [accepted]
PHST- 2017/07/04 06:00 [entrez]
PHST- 2017/07/04 06:00 [pubmed]
PHST- 2017/10/11 06:00 [medline]
PHST- 2017/07/01 00:00 [pmc-release]
AID - 10.3348/kjr.2017.18.4.643 [doi]
PST - ppublish
SO  - Korean J Radiol. 2017 Jul-Aug;18(4):643-654. doi: 10.3348/kjr.2017.18.4.643. Epub 
      2017 May 19.