PMID- 28670512
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2228-5806 (Print)
IS  - 2228-5814 (Electronic)
IS  - 2228-5806 (Linking)
VI  - 19
IP  - 2
DP  - 2017 Jul-Sep
TI  - Signaling Molecules Governing Pluripotency and Early Lineage Commitments in Human 
      Pluripotent Stem Cells.
PG  - 194-203
LID - 10.22074/cellj.2016.3915 [doi]
AB  - Signaling in pluripotent stem cells is a complex and dynamic process involving 
      multiple mediators, finely tuned to balancing pluripotency and differentiation 
      states. Characterizing and modifying the necessary signaling pathways to attain 
      desired cell types is required for stem-cell applications in various fields of 
      regenerative medicine. These signals may help enhance the differentiation 
      potential of pluripotent cells towards each of the embryonic lineages and enable 
      us to achieve pure in vitro cultures of various cell types. This review provides 
      a timely synthesis of recent advances into how maintenance of pluripotency in 
      hPSCs is regulated by extrinsic cues, such as the fibroblast growth factor (FGF) 
      and ACTIVIN signaling pathways, their interplay with other signaling pathways, 
      namely, wingless- type MMTV integration site family (WNT) and mammalian target of 
      rapamycin (mTOR), and the pathways governing the determination of multiple 
      lineages.
FAU - Fathi, Ali
AU  - Fathi A
AD  - Department of Stem Cells and Developmental Biology, Cell Science Research Center, 
      Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
FAU - Eisa-Beygi, Shahram
AU  - Eisa-Beygi S
AD  - Department of Stem Cells and Developmental Biology, Cell Science Research Center, 
      Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
FAU - Baharvand, Hossein
AU  - Baharvand H
AD  - Department of Stem Cells and Developmental Biology, Cell Science Research Center, 
      Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
AD  - Department of Developmental Biology, University of Science and Culture, ACECR, 
      Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170222
PL  - Iran
TA  - Cell J
JT  - Cell journal
JID - 101566618
PMC - PMC5412778
OTO - NOTNLM
OT  - Differentiation
OT  - Nodal
OT  - Stem Cell
EDAT- 2017/07/04 06:00
MHDA- 2017/07/04 06:01
PMCR- 2017/07/01
CRDT- 2017/07/04 06:00
PHST- 2016/03/07 00:00 [received]
PHST- 2016/07/15 00:00 [accepted]
PHST- 2017/07/04 06:00 [entrez]
PHST- 2017/07/04 06:00 [pubmed]
PHST- 2017/07/04 06:01 [medline]
PHST- 2017/07/01 00:00 [pmc-release]
AID - 10.22074/cellj.2016.3915 [doi]
PST - ppublish
SO  - Cell J. 2017 Jul-Sep;19(2):194-203. doi: 10.22074/cellj.2016.3915. Epub 2017 Feb 
      22.