PMID- 28670961
OWN - NLM
STAT- MEDLINE
DCOM- 20170807
LR  - 20170807
IS  - 1941-9260 (Electronic)
IS  - 0032-5481 (Linking)
VI  - 129
IP  - 6
DP  - 2017 Aug
TI  - Rationales and choices for the treatment of patients with NYHA class II heart 
      failure.
PG  - 619-631
LID - 10.1080/00325481.2017.1344082 [doi]
AB  - Heart failure (HF) in the United States represents a significant burden for 
      patients and a tremendous strain on the healthcare system. Patients receiving a 
      diagnosis of HF can be placed into 1 of 4 New York Heart Association (NYHA) 
      functional classifications; the greatest proportion of patients are in the NYHA 
      class II category, which is defined as patients having a slight limitation of 
      physical activity but who are comfortable at rest, and for whom ordinary physical 
      activity results in symptoms of HF. Because the severity of NYHA class II HF may 
      be perceived as mild or unalarming by this definition, the urgency to treat this 
      type of HF may be overlooked. However, these patients are optimal candidates for 
      active intervention because their HF is at a critical point on the disease 
      progression continuum when untoward changes can be halted or reversed. This 
      review discusses the physiological consequences of NYHA class II HF with reduced 
      ejection fraction and describes recent clinical trials that have demonstrated a 
      therapeutic benefit for patients in this population. In doing so, we hope to 
      establish that patients with NYHA class II disease merit careful attention and to 
      provide reassurance to the treating community that options are available for 
      these patients.
FAU - Gilbert, Edward M
AU  - Gilbert EM
AD  - a Division of Cardiology , University of Utah , Salt Lake City , UT , USA.
FAU - Xu, Weining David
AU  - Xu WD
AD  - a Division of Cardiology , University of Utah , Salt Lake City , UT , USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170714
PL  - England
TA  - Postgrad Med
JT  - Postgraduate medicine
JID - 0401147
SB  - IM
MH  - Decision Making
MH  - Disease Progression
MH  - Heart Failure/epidemiology/*physiopathology/*therapy
MH  - Humans
MH  - Severity of Illness Index
MH  - United States/epidemiology
OTO - NOTNLM
OT  - Heart failure
OT  - New York Heart Association class II heart failure
OT  - pathophysiology
OT  - reduced ejection fraction
EDAT- 2017/07/04 06:00
MHDA- 2017/08/08 06:00
CRDT- 2017/07/04 06:00
PHST- 2017/07/04 06:00 [pubmed]
PHST- 2017/08/08 06:00 [medline]
PHST- 2017/07/04 06:00 [entrez]
AID - 10.1080/00325481.2017.1344082 [doi]
PST - ppublish
SO  - Postgrad Med. 2017 Aug;129(6):619-631. doi: 10.1080/00325481.2017.1344082. Epub 
      2017 Jul 14.