PMID- 28671000
OWN - NLM
STAT- MEDLINE
DCOM- 20180410
LR  - 20181202
IS  - 1502-4725 (Electronic)
IS  - 0803-9488 (Linking)
VI  - 71
IP  - 7
DP  - 2017 Oct
TI  - Brain-derived neurotrophic factor serum and plasma levels in the treatment of 
      acute schizophrenia with olanzapine or risperidone: 6-week prospective study.
PG  - 513-520
LID - 10.1080/08039488.2017.1340518 [doi]
AB  - Antipsychotics have been the mainstay of the treatment of schizophrenia, and 
      their potential role in neuroprotection could be related to brain-derived 
      neurotrophic factor (BDNF). So far different effects on both serum and plasma 
      levels of BDNF were reported related to the various antipsychotic treatments. Aim 
      of this study was to investigate the influence of olanzapine or risperidone on 
      both plasma and serum levels of BDNF in patients with acute schizophrenia. For 50 
      participants with acute episode of schizophrenia both plasma and serum BDNF, 
      along with the Positive and Negative Syndrome Scale (PANSS) and the Clinical 
      Global Impression scale, were assessed pretreatment and post treatment - after 6 
      weeks of either risperidone or olanzapine. Results show that a weak correlation 
      between pretreatment plasma and serum levels of BNDF was found no longer 
      significant after 6 weeks of treatment. Antipsychotics, olanzapine and 
      risperidone showed no significant effect on post treatment plasma and serum 
      levels of BDNF. Pretreatment plasma level of BDNF and PANSS positive subscale 
      were positively correlated. Post treatment serum level of BDNF and Clinical 
      Global Impression were negatively correlated. In conclusion, plasma and serum 
      BDNF levels could be different markers to some extent with regard to clinical 
      symptoms, response to therapy and outcome. The interrelation between serum and 
      plasma BDNF should be established in further studies.
FAU - Kudlek Mikulic, Suzan
AU  - Kudlek Mikulic S
AD  - a Department of Psychiatry, Clinical Hospital Center Zagreb , Zagreb , Croatia.
FAU - Mihaljevic-Peles, Alma
AU  - Mihaljevic-Peles A
AD  - b Department of Psychiatry, School of Medicine , Clinical Hospital Center Zagreb, 
      University of Zagreb , Zagreb , Croatia.
FAU - Sagud, Marina
AU  - Sagud M
AD  - b Department of Psychiatry, School of Medicine , Clinical Hospital Center Zagreb, 
      University of Zagreb , Zagreb , Croatia.
FAU - Bajs Janovic, Maja
AU  - Bajs Janovic M
AD  - a Department of Psychiatry, Clinical Hospital Center Zagreb , Zagreb , Croatia.
FAU - Ganoci, Lana
AU  - Ganoci L
AD  - c Department of Laboratory Diagnostics , Clinical Hospital Centre Zagreb , Zagreb 
      , Croatia.
FAU - Grubisin, Jasmina
AU  - Grubisin J
AD  - a Department of Psychiatry, Clinical Hospital Center Zagreb , Zagreb , Croatia.
FAU - Kuzman Rojnic, Martina
AU  - Kuzman Rojnic M
AD  - b Department of Psychiatry, School of Medicine , Clinical Hospital Center Zagreb, 
      University of Zagreb , Zagreb , Croatia.
FAU - Vuksan Cusa, Bjanka
AU  - Vuksan Cusa B
AD  - a Department of Psychiatry, Clinical Hospital Center Zagreb , Zagreb , Croatia.
AD  - d Faculty of Medicine , Josip Juraj Strossmayer University of Osijek , Osijek , 
      Croatia.
FAU - Bradas, Zoran
AU  - Bradas Z
AD  - a Department of Psychiatry, Clinical Hospital Center Zagreb , Zagreb , Croatia.
FAU - Bozina, Nada
AU  - Bozina N
AD  - e Department of Laboratory Diagnostics, School of Medicine , Clinical Hospital 
      Centre Zagreb, University of Zagreb , Zagreb , Croatia.
LA  - eng
PT  - Journal Article
DEP - 20170702
PL  - England
TA  - Nord J Psychiatry
JT  - Nordic journal of psychiatry
JID - 100927567
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 12794-10-4 (Benzodiazepines)
RN  - L6UH7ZF8HC (Risperidone)
RN  - N7U69T4SZR (Olanzapine)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Age Factors
MH  - Antipsychotic Agents/*therapeutic use
MH  - Benzodiazepines/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Olanzapine
MH  - Prospective Studies
MH  - Risperidone/*therapeutic use
MH  - Schizophrenia/*blood/*drug therapy
MH  - Sex Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Serum BDNF
OT  - olanzapine
OT  - plasma BDNF
OT  - risperidone
OT  - schizophrenia
EDAT- 2017/07/04 06:00
MHDA- 2018/04/11 06:00
CRDT- 2017/07/04 06:00
PHST- 2017/07/04 06:00 [pubmed]
PHST- 2018/04/11 06:00 [medline]
PHST- 2017/07/04 06:00 [entrez]
AID - 10.1080/08039488.2017.1340518 [doi]
PST - ppublish
SO  - Nord J Psychiatry. 2017 Oct;71(7):513-520. doi: 10.1080/08039488.2017.1340518. 
      Epub 2017 Jul 2.