PMID- 28672073
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20220311
IS  - 1520-6394 (Electronic)
IS  - 1091-4269 (Print)
IS  - 1091-4269 (Linking)
VI  - 34
IP  - 12
DP  - 2017 Dec
TI  - Prediction of treatment outcomes to exercise in patients with nonremitted major 
      depressive disorder.
PG  - 1116-1122
LID - 10.1002/da.22670 [doi]
AB  - BACKGROUND: Only one-third of patients with major depressive disorder (MDD) 
      achieve remission with initial treatment. Consequently, current clinical practice 
      relies on a "trial-and-error" approach to identify an effective treatment for 
      each patient. The purpose of this report was to determine whether we could 
      identify a set of clinical and biological parameters with potential clinical 
      utility for prescription of exercise for treatment of MDD in a secondary analysis 
      of the Treatment with Exercise Augmentation in Depression (TREAD) trial. METHODS: 
      Participants with nonremitted MDD were randomized to one of two exercise doses 
      for 12 weeks. Participants were categorized as "remitters" (</=12 on the IDS-C), 
      nonresponders (<30% drop in IDS-C), or neither. The least absolute shrinkage and 
      selection operator (LASSO) and random forests were used to evaluate 30 variables 
      as predictors of both remission and nonresponse. Predictors were used to model 
      treatment outcomes using logistic regression. RESULTS: Of the 122 participants, 
      36 were categorized as remitters (29.5%), 56 as nonresponders (45.9%), and 30 as 
      neither (24.6%). Predictors of remission were higher levels of brain-derived 
      neurotrophic factor (BDNF) and IL-1B, greater depressive symptom severity, and 
      higher postexercise positive affect. Predictors of treatment nonresponse were low 
      cardiorespiratory fitness, lower levels of IL-6 and BDNF, and lower postexercise 
      positive affect. Models including these predictors resulted in predictive values 
      greater than 70% (true predicted remitters/all predicted remitters) with 
      specificities greater than 25% (true predicted remitters/all remitters). 
      CONCLUSIONS: Results indicate feasibility in identifying patients who will either 
      remit or not respond to exercise as a treatment for MDD utilizing a clinical 
      decision model that incorporates multiple patient characteristics.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Rethorst, Chad D
AU  - Rethorst CD
AUID- ORCID: 0000-0002-8168-2829
AD  - Department of Psychiatry, Center for Depression Research and Clinical Care, 
      University of Texas Southwestern Medical Center, Dallas, TX, USA.
FAU - South, Charles C
AU  - South CC
AD  - Department of Psychiatry, Center for Depression Research and Clinical Care, 
      University of Texas Southwestern Medical Center, Dallas, TX, USA.
FAU - Rush, A John
AU  - Rush AJ
AD  - Duke-National University of Singapore, Singapore, Singapore.
FAU - Greer, Tracy L
AU  - Greer TL
AD  - Department of Psychiatry, Center for Depression Research and Clinical Care, 
      University of Texas Southwestern Medical Center, Dallas, TX, USA.
FAU - Trivedi, Madhukar H
AU  - Trivedi MH
AUID- ORCID: 0000-0002-2983-1110
AD  - Department of Psychiatry, Center for Depression Research and Clinical Care, 
      University of Texas Southwestern Medical Center, Dallas, TX, USA.
LA  - eng
GR  - K01 MH097847/MH/NIMH NIH HHS/United States
GR  - R01 MH067692/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170703
PL  - United States
TA  - Depress Anxiety
JT  - Depression and anxiety
JID - 9708816
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Depressive Disorder, Major/blood/physiopathology/*therapy
MH  - Exercise Therapy/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Outcome Assessment, Health Care/*methods
MH  - Young Adult
PMC - PMC5718947
MID - NIHMS885588
OTO - NOTNLM
OT  - decision support techniques
OT  - depression
OT  - exercise
OT  - treatment outcomes
EDAT- 2017/07/04 06:00
MHDA- 2018/06/05 06:00
PMCR- 2018/12/01
CRDT- 2017/07/04 06:00
PHST- 2017/03/02 00:00 [received]
PHST- 2017/04/27 00:00 [revised]
PHST- 2017/05/20 00:00 [accepted]
PHST- 2017/07/04 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
PHST- 2017/07/04 06:00 [entrez]
PHST- 2018/12/01 00:00 [pmc-release]
AID - 10.1002/da.22670 [doi]
PST - ppublish
SO  - Depress Anxiety. 2017 Dec;34(12):1116-1122. doi: 10.1002/da.22670. Epub 2017 Jul 
      3.