PMID- 28672131
OWN - NLM
STAT- MEDLINE
DCOM- 20170828
LR  - 20181202
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 158
DP  - 2017 Oct
TI  - Association between serum persistent organic pollutants and DNA methylation in 
      Korean adults.
PG  - 333-341
LID - S0013-9351(17)30181-0 [pii]
LID - 10.1016/j.envres.2017.06.017 [doi]
AB  - BACKGROUND: Exposure to persistent organic pollutants (POPs) has been associated 
      with epigenetic changes such as DNA methylation, which can influence human 
      health. However, the association between POPs and DNA methylation by sex was not 
      shown in previous studies. OBJECTIVES: We investigated the association between 
      POPs and DNA methylation in men and women using a larger population. METHODS: A 
      cross-sectional study was conducted using the data of 444 Koreans (253 men and 
      191 women). Measurements for sixteen different POPs, including six organochlorine 
      pesticides (OCPs) and ten polychlorinated biphenyls (PCBs) were taken in serum. 
      DNA methylation via Alu and LINE-1 in peripheral leukocytes was measured by 
      pyrosequencing. To evaluate the association between POPs and DNA methylation, the 
      Pearson's correlation and multiple linear regression analyses were performed. 
      RESULTS: Except for PCB52 and PCB101, we found significant inverse associations 
      between p,p'-DDE, cis-Heptachlor epoxide, and PCBs and Alu assay in men after 
      adjusting for age, BMI, smoking status, and alcohol consumption (beta = -0.67 for 
      p,p'-DDE; -0.28 for cis-Heptachlor epoxide; in the range from -0.43 to -1.60 for 
      PCBs). In women, PCB153 and PCB180 showed statistically significant inverse 
      association with Alu assay (beta = -0.22 for PCB153; -0.22 for PCB180). Except for 
      PCB101, p,p'-DDE and PCBs were positively associated with LINE-1 assay in women 
      (beta = 0.48 for p,p'-DDE; in the range from 0.40-0.89 for PCBs) while p,p'-DDE, 
      PCB153, and PCB180 showed positive associations with LINE-1 assay in men (beta = 
      0.55 for p,p'-DDE; 0.65 for PCB153; 1.02 for PCB180). CONCLUSIONS: We found that 
      several POPs were associated with global DNA hypomethylation in the Alu assay for 
      men and global DNA hypermethylation in the LINE-1 assay for women.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Lee, Mi Hwa
AU  - Lee MH
AD  - Institute for Health and Society, Hanyang University, Seoul, Republic of Korea.
FAU - Cho, Eo Rin
AU  - Cho ER
AD  - Institute for Health Promotion & Department of Epidemiology and Health Promotion, 
      Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea.
FAU - Lim, Jung-Eun
AU  - Lim JE
AD  - Institute for Health Promotion & Department of Epidemiology and Health Promotion, 
      Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea; 
      College of Pharmacy, Ewha Womans University, Seoul, Republic of Korea.
FAU - Jee, Sun Ha
AU  - Jee SH
AD  - Institute for Health Promotion & Department of Epidemiology and Health Promotion, 
      Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea. 
      Electronic address: jsunha@yuhs.ac.
LA  - eng
PT  - Journal Article
DEP - 20170630
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cities
MH  - Cross-Sectional Studies
MH  - *DNA Methylation
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - Male
MH  - Middle Aged
MH  - Pesticides/*blood
MH  - Polychlorinated Biphenyls/*blood
MH  - Regression Analysis
MH  - Republic of Korea
MH  - Seoul
MH  - Sex Factors
MH  - Young Adult
OTO - NOTNLM
OT  - Alu
OT  - DNA methylation
OT  - Epigenetics
OT  - LINE-1
OT  - Persistent organic pollutants (POPs)
EDAT- 2017/07/04 06:00
MHDA- 2017/08/29 06:00
CRDT- 2017/07/04 06:00
PHST- 2017/01/30 00:00 [received]
PHST- 2017/06/17 00:00 [revised]
PHST- 2017/06/19 00:00 [accepted]
PHST- 2017/07/04 06:00 [pubmed]
PHST- 2017/08/29 06:00 [medline]
PHST- 2017/07/04 06:00 [entrez]
AID - S0013-9351(17)30181-0 [pii]
AID - 10.1016/j.envres.2017.06.017 [doi]
PST - ppublish
SO  - Environ Res. 2017 Oct;158:333-341. doi: 10.1016/j.envres.2017.06.017. Epub 2017 
      Jun 30.