PMID- 28672223
OWN - NLM
STAT- MEDLINE
DCOM- 20170721
LR  - 20171220
IS  - 1096-0341 (Electronic)
IS  - 0042-6822 (Linking)
VI  - 509
DP  - 2017 Sep
TI  - Complete genome sequence of Ostreid herpesvirus type 1 microVar isolated during 
      mortality events in the Pacific oyster Crassostrea gigas in France and Ireland.
PG  - 239-251
LID - S0042-6822(17)30204-0 [pii]
LID - 10.1016/j.virol.2017.06.027 [doi]
AB  - Infections with Ostreid herpesvirus 1 (OsHV-1) microvariants in young Pacific 
      oysters are associated with massive mortality events and significant economic 
      losses. Previous studies, focusing on few regions of the genome, have revealed 
      the genomic diversity of these genotypes with respect to the reference type. We 
      used a NGS process to sequence the whole genome of the OsHV-1 microVar in infected 
      individuals, collected during mortality events in France and Ireland. The final 
      genome length of OsHV-1 microVar was approximately 205kbp, shorter than the reference 
      genotype and the overall genome organisation resembled herpes simplex viruses. 
      94.4% similarity was observed with the OsHV-1 reference genotype. Large indels, 
      including five deletions and three insertions were found to induce the loss and 
      the addition of several ORFs, summed with codon substitutions in 64% of genes 
      shared with the reference type. This diversity raises the question of the exact 
      origin and evolution of OsHV-1 microVar.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Burioli, E A V
AU  - Burioli EAV
AD  - Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, 
      Torino, Italy; Department of Veterinary Medical Sciences, Alma Mater Studiorum, 
      Universita di Bologna, Ozzano dell'Emilia, BO, Italy. Electronic address: 
      erikaastrid.burioli@studio.unibo.it.
FAU - Prearo, M
AU  - Prearo M
AD  - Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, 
      Torino, Italy.
FAU - Houssin, M
AU  - Houssin M
AD  - Laboratoire Frank Duncombe LABEO, Caen, France.
LA  - eng
PT  - Journal Article
DEP - 20170630
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Animals
MH  - Cluster Analysis
MH  - Crassostrea/*virology
MH  - DNA, Viral/*chemistry/*genetics
MH  - France
MH  - Gene Order
MH  - *Genome, Viral
MH  - Herpesviridae/*genetics/isolation & purification
MH  - INDEL Mutation
MH  - Ireland
MH  - Phylogeny
MH  - Sequence Analysis, DNA
MH  - Sequence Homology
MH  - Synteny
OTO - NOTNLM
OT  - Complete genome
OT  - Crassostrea gigas
OT  - Indels
OT  - NGS
OT  - Ostreid herpesvirus-1 microVar
EDAT- 2017/07/04 06:00
MHDA- 2017/07/22 06:00
CRDT- 2017/07/04 06:00
PHST- 2016/12/23 00:00 [received]
PHST- 2017/06/14 00:00 [revised]
PHST- 2017/06/23 00:00 [accepted]
PHST- 2017/07/04 06:00 [pubmed]
PHST- 2017/07/22 06:00 [medline]
PHST- 2017/07/04 06:00 [entrez]
AID - S0042-6822(17)30204-0 [pii]
AID - 10.1016/j.virol.2017.06.027 [doi]
PST - ppublish
SO  - Virology. 2017 Sep;509:239-251. doi: 10.1016/j.virol.2017.06.027. Epub 2017 Jun 
      30.