PMID- 28672978
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 14
IP  - 1
DP  - 2017 Jul
TI  - Oral administration of lactobacilli isolated from Jeotgal, a salted fermented 
      seafood, inhibits the development of 2,4-dinitrofluorobenzene-induced atopic 
      dermatitis in mice.
PG  - 635-641
LID - 10.3892/etm.2017.4536 [doi]
AB  - Certain strains of lactobacilli have been reported to exert favorable effects on 
      atopic dermatitis (AD). Jeotgal, a traditional Korean food, is a salted fermented 
      seafood known to harbor many lactic acid bacteria. In the present study, two 
      novel lactobacillus strains were isolated from Jeotgal, and their anti-AD effects 
      were investigated. Lactobacilli isolated from Jeotgal were identified, according 
      to conjugated linoleic acid-producing activity, as Lactobacillus plantarum 
      (JBCC105645 and JBCC105683). AD-like skin lesions were induced in BALB/c mice 
      using dinitrofluorobenzene (DNFB). Ear swelling, histological analysis and serum 
      immunoglobulin E (IgE) levels in mice were evaluated to investigate the anti-AD 
      effects of lactobacilli. Cytokine production of ex vivo cluster of 
      differentiation (CD)4(+) T cells, and interleukin (IL)-12 production of in vitro 
      macrophages were also evaluated to establish a putative mechanism of the action 
      of lactobacilli. Administration of JBCC105645 or JBCC105683 suppressed ear 
      swelling and serum IgE levels in DNFB-treated mice (P<0.05). Notably, JBCC105645 
      was more effective than JBCC105683 (P<0.05). Treatment with the lactobacilli also 
      induced a significant decrease in IL-4 production with concomitant increase in 
      interferon (IFN)-gamma production in DNFB-exposed CD4(+) T cells, and an increase in 
      IL-12 production in macrophages (P<0.05). Taken together, the lactobacilli 
      isolated from Jeotgal may suppress the development of AD-like skin inflammation 
      in mice by modulating IL-4 and IFN-gamma production in CD4(+) T cells, presumably via 
      enhancing IL-12 production by macrophages.
FAU - Park, Mi-Sung
AU  - Park MS
AD  - Institute for Metabolic Disease, Wonkwang University, Iksan, Jeollabuk 570-749, 
      Republic of Korea.
FAU - Song, Nho-Eul
AU  - Song NE
AD  - Department of Food Science and Human Nutrition, and Fermented Food Research 
      Center, Chonbuk National University, Jeonju, Jeollabuk 561-756, Republic of 
      Korea.
FAU - Baik, Sang-Ho
AU  - Baik SH
AD  - Department of Food Science and Human Nutrition, and Fermented Food Research 
      Center, Chonbuk National University, Jeonju, Jeollabuk 561-756, Republic of 
      Korea.
FAU - Pae, Hyun-Ock
AU  - Pae HO
AD  - Department of Microbiology and Immunology, Wonkwang University School of 
      Medicine, Iksan, Jeollabuk 570-749, Republic of Korea.
FAU - Park, Seong Hoon
AU  - Park SH
AD  - Institute for Metabolic Disease, Wonkwang University, Iksan, Jeollabuk 570-749, 
      Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20170601
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5488544
OTO - NOTNLM
OT  - atopic dermatitis
OT  - immunoglobulin E
OT  - interferon-gamma
OT  - interleukin-4
OT  - lactobacilli
EDAT- 2017/07/05 06:00
MHDA- 2017/07/05 06:01
PMCR- 2017/06/01
CRDT- 2017/07/05 06:00
PHST- 2016/05/11 00:00 [received]
PHST- 2017/03/03 00:00 [accepted]
PHST- 2017/07/05 06:00 [entrez]
PHST- 2017/07/05 06:00 [pubmed]
PHST- 2017/07/05 06:01 [medline]
PHST- 2017/06/01 00:00 [pmc-release]
AID - ETM-0-0-4536 [pii]
AID - 10.3892/etm.2017.4536 [doi]
PST - ppublish
SO  - Exp Ther Med. 2017 Jul;14(1):635-641. doi: 10.3892/etm.2017.4536. Epub 2017 Jun 
      1.