PMID- 28673192
OWN - NLM
STAT- MEDLINE
DCOM- 20180627
LR  - 20201218
IS  - 1940-2465 (Electronic)
IS  - 1066-8969 (Linking)
VI  - 25
IP  - 8
DP  - 2017 Dec
TI  - Association Between Clinicopathological Factors and Genomic Abnormalities 
      Detected by FISH Analysis in Epithelioid Diffuse Malignant Pleural Mesothelioma.
PG  - 668-673
LID - 10.1177/1066896917716773 [doi]
AB  - BACKGROUND: Abnormality of genes including 9p21 is known in malignant 
      mesothelioma and we have examined the frequency of gene deletion and 
      amplification using the fluorescence in situ hybridization (FISH) method. We 
      formerly reported that abnormality of the genes was more common in the 
      sarcomatoid type than epithelioid type. In this study, we compared the 
      clinicopathological factors including nuclear grade (NG) and genomic abnormality 
      in epithelioid malignant pleural mesothelioma (MPM). METHODS: Using 
      paraffin-embedded tissues of 31 epithelioid MPMs, we investigated the presence of 
      gene abnormalities in the genes 9p21, 1p36, 14q32, 22q12, 5p15, 6p, 8q24, and 
      7p12 by the FISH method, and compared the results with NG, clinical stage, and 
      prognosis. RESULTS: In the higher NG group of epithelioid MPM, more gene 
      amplifications [in particular 5p15 and 8q24(MYC)] were observed, and clinical 
      stage was more advanced. Cases with the amplification of 7p12(EGFR) tended to 
      exhibit a worse prognosis. The significant correlation between histological 
      differentiation and clinical features such as prognosis was not confirmed. 
      CONCLUSIONS: NG status in epithelioid MPM may be related to gene alteration and 
      clinical features.
FAU - Takeda, Maiko
AU  - Takeda M
AD  - 1 Nara Medical University School of Medicine, Kashihara, Nara, Japan.
AD  - 2 National Hospital Organization Kinki-chuo Chest Medical Center, Osaka, Japan.
FAU - Kasai, Takahiko
AU  - Kasai T
AD  - 2 National Hospital Organization Kinki-chuo Chest Medical Center, Osaka, Japan.
FAU - Hatakeyama, Kinta
AU  - Hatakeyama K
AD  - 1 Nara Medical University School of Medicine, Kashihara, Nara, Japan.
FAU - Nakai, Tokiko
AU  - Nakai T
AD  - 1 Nara Medical University School of Medicine, Kashihara, Nara, Japan.
FAU - Itami, Hiroe
AU  - Itami H
AD  - 1 Nara Medical University School of Medicine, Kashihara, Nara, Japan.
FAU - Uchiyama, Tomoko
AU  - Uchiyama T
AD  - 1 Nara Medical University School of Medicine, Kashihara, Nara, Japan.
FAU - IIzuka, Norishige
AU  - IIzuka N
AD  - 3 Kishiwada City Hospital, Osaka, Japan.
FAU - Maruyama, Hiroshi
AU  - Maruyama H
AD  - 4 Hoshigaoka Medical Center, JCHO, Osaka, Japan.
FAU - Ohbayashi, Chiho
AU  - Ohbayashi C
AD  - 1 Nara Medical University School of Medicine, Kashihara, Nara, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170703
PL  - United States
TA  - Int J Surg Pathol
JT  - International journal of surgical pathology
JID - 9314927
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Aged
MH  - Biomarkers, Tumor/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lung Neoplasms/*genetics/*pathology
MH  - Male
MH  - Mesothelioma/*genetics/*pathology
MH  - Mesothelioma, Malignant
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Pleural Neoplasms/*genetics/*pathology
OTO - NOTNLM
OT  - FISH
OT  - mesothelioma
OT  - nuclear grade
OT  - pleura
EDAT- 2017/07/05 06:00
MHDA- 2018/06/28 06:00
CRDT- 2017/07/05 06:00
PHST- 2017/07/05 06:00 [pubmed]
PHST- 2018/06/28 06:00 [medline]
PHST- 2017/07/05 06:00 [entrez]
AID - 10.1177/1066896917716773 [doi]
PST - ppublish
SO  - Int J Surg Pathol. 2017 Dec;25(8):668-673. doi: 10.1177/1066896917716773. Epub 
      2017 Jul 3.