PMID- 28673351
OWN - NLM
STAT- MEDLINE
DCOM- 20180416
LR  - 20181113
IS  - 1465-993X (Electronic)
IS  - 1465-9921 (Print)
IS  - 1465-9921 (Linking)
VI  - 18
IP  - 1
DP  - 2017 Jul 3
TI  - Is it possible to claim or refute sputum eosinophils >/= 3% in asthmatics with 
      sufficient accuracy using biomarkers?
PG  - 133
LID - 10.1186/s12931-017-0615-9 [doi]
LID - 133
AB  - The concept of asthma inflammatory phenotypes has proved to be important in 
      predicting response to inhaled corticosteroids. Induced sputum, which has been 
      pivotal in the development of the concept of inflammatory phenotypes, is however 
      not widely available. Several studies have proposed to use surrogate exhaled or 
      blood biomarkers, like fractional exhaled nitric oxide (FENO), blood eosinophils 
      and total serum immunoglobulin E (IgE). However, taken alone, each of these 
      biomarkers has moderate accuracy to identify sputum eosinophilia. Here, we 
      propose a new approach based on the likelihood ratio to study which thresholds of 
      these biomarkers, taken alone or in combination, were able to rule in or rule out 
      sputum eosinophils >/=3%. We showed in a large population of 869 asthmatics that 
      combining FENO, blood eosinophils and total serum IgE could accurately predict 
      sputum eosinophils >/= or <3% in 58% of our population.
FAU - Demarche, Sophie F
AU  - Demarche SF
AUID- ORCID: 0000-0002-5628-0262
AD  - Department of Respiratory Medicine, CHU Liege, GIGA I3 Research Group, University 
      of Liege, Liege, Belgium. Sophie.Demarche@ulg.ac.be.
AD  - Department of Clinical Pharmacy, Center for Interdisciplinary Research on 
      Medicines, University of Liege, Liege, Belgium. Sophie.Demarche@ulg.ac.be.
FAU - Schleich, Florence N
AU  - Schleich FN
AD  - Department of Respiratory Medicine, CHU Liege, GIGA I3 Research Group, University 
      of Liege, Liege, Belgium.
FAU - Paulus, Virginie A
AU  - Paulus VA
AD  - Department of Respiratory Medicine, CHU Liege, GIGA I3 Research Group, University 
      of Liege, Liege, Belgium.
FAU - Henket, Monique A
AU  - Henket MA
AD  - Department of Respiratory Medicine, CHU Liege, GIGA I3 Research Group, University 
      of Liege, Liege, Belgium.
FAU - Van Hees, Thierry J
AU  - Van Hees TJ
AD  - Department of Clinical Pharmacy, Center for Interdisciplinary Research on 
      Medicines, University of Liege, Liege, Belgium.
FAU - Louis, Renaud E
AU  - Louis RE
AD  - Department of Respiratory Medicine, CHU Liege, GIGA I3 Research Group, University 
      of Liege, Liege, Belgium.
LA  - eng
PT  - Letter
PT  - Research Support, Non-U.S. Gov't
DEP - 20170703
PL  - England
TA  - Respir Res
JT  - Respiratory research
JID - 101090633
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Asthma/blood/*diagnosis/*metabolism
MH  - Biomarkers/blood/metabolism
MH  - Cross-Sectional Studies
MH  - Eosinophils/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Sputum/*metabolism
PMC - PMC5496313
OTO - NOTNLM
OT  - Asthma
OT  - Biomarkers
OT  - Blood
OT  - Eosinophils
OT  - Immunoglobulin E
OT  - Nitric oxide
OT  - Phenotype
OT  - Sputum
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: The study was approved by the ethics 
      committee of the University Hospital of Liege (Ref 2016/276). CONSENT FOR 
      PUBLICATION: Not applicable. COMPETING INTERESTS: SD, FS, VP, MH: no competing 
      interests. TVH: grants from Amgen, outside the submitted work. RL: grants and 
      personal fees from GSK, Chiesi, Astra Zeneca, Novartis, outside the submitted 
      work. PUBLISHER'S NOTE: Springer Nature remains neutral with regard to 
      jurisdictional claims in published maps and institutional affiliations.
EDAT- 2017/07/05 06:00
MHDA- 2018/04/17 06:00
PMCR- 2017/07/03
CRDT- 2017/07/05 06:00
PHST- 2017/05/04 00:00 [received]
PHST- 2017/06/25 00:00 [accepted]
PHST- 2017/07/05 06:00 [entrez]
PHST- 2017/07/05 06:00 [pubmed]
PHST- 2018/04/17 06:00 [medline]
PHST- 2017/07/03 00:00 [pmc-release]
AID - 10.1186/s12931-017-0615-9 [pii]
AID - 615 [pii]
AID - 10.1186/s12931-017-0615-9 [doi]
PST - epublish
SO  - Respir Res. 2017 Jul 3;18(1):133. doi: 10.1186/s12931-017-0615-9.