PMID- 28674106
OWN - NLM
STAT- MEDLINE
DCOM- 20180405
LR  - 20181113
IS  - 1573-4935 (Electronic)
IS  - 0144-8463 (Print)
IS  - 0144-8463 (Linking)
VI  - 37
IP  - 4
DP  - 2017 Aug 31
TI  - CRISPR-Cas adaptive immunity and the three Rs.
LID - BSR20160297 [pii]
LID - 10.1042/BSR20160297 [doi]
AB  - In this summary, we focus on fundamental biology of Clustered Regularly 
      Interspersed Short Palindromic Repeats (CRISPR)-Cas (CRISPR-associated proteins) 
      adaptive immunity in bacteria. Emphasis is placed on emerging information about 
      functional interplay between Cas proteins and proteins that remodel DNA during 
      homologous recombination (HR), DNA replication or DNA repair. We highlight how 
      replication forks may act as 'trigger points' for CRISPR adaptation events, and 
      the potential for cascade-interference complexes to act as precise roadblocks in 
      DNA replication by an invader MGE (mobile genetic element), without the need for 
      DNA double-strand breaks.
CI  - (c) 2017 The Author(s).
FAU - Killelea, Tom
AU  - Killelea T
AD  - School of Life Sciences, University of Nottingham, Nottingham, NG7 2UH, UK 
      tom.killelea@nottingham.ac.uk ed.bolt@nottingham.ac.uk.
FAU - Bolt, Edward L
AU  - Bolt EL
AD  - School of Life Sciences, University of Nottingham, Nottingham, NG7 2UH, UK 
      tom.killelea@nottingham.ac.uk ed.bolt@nottingham.ac.uk.
LA  - eng
PT  - Editorial
DEP - 20170716
PL  - England
TA  - Biosci Rep
JT  - Bioscience reports
JID - 8102797
RN  - 0 (DNA, Bacterial)
SB  - IM
MH  - Bacteria/genetics/*metabolism
MH  - CRISPR-Cas Systems/*physiology
MH  - DNA Repair/*physiology
MH  - DNA Replication/*physiology
MH  - DNA, Bacterial/*biosynthesis/genetics
MH  - Homologous Recombination/*physiology
PMC - PMC5518543
OTO - NOTNLM
OT  - CRISPR
OT  - recombination
OT  - replication
COIS- The authors declare that there are no competing interests associated with the 
      manuscript.
EDAT- 2017/07/05 06:00
MHDA- 2018/04/06 06:00
PMCR- 2017/07/17
CRDT- 2017/07/05 06:00
PHST- 2017/04/13 00:00 [received]
PHST- 2017/06/26 00:00 [revised]
PHST- 2017/07/03 00:00 [accepted]
PHST- 2017/07/05 06:00 [pubmed]
PHST- 2018/04/06 06:00 [medline]
PHST- 2017/07/05 06:00 [entrez]
PHST- 2017/07/17 00:00 [pmc-release]
AID - BSR20160297 [pii]
AID - 10.1042/BSR20160297 [doi]
PST - epublish
SO  - Biosci Rep. 2017 Jul 16;37(4):BSR20160297. doi: 10.1042/BSR20160297. Print 2017 
      Aug 31.