PMID- 28674350
OWN - NLM
STAT- MEDLINE
DCOM- 20180105
LR  - 20190115
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Print)
IS  - 0918-2918 (Linking)
VI  - 56
IP  - 13
DP  - 2017
TI  - Depression Is Significantly Associated with the Health Status in Patients with 
      Idiopathic Pulmonary Fibrosis.
PG  - 1637-1644
LID - 10.2169/internalmedicine.56.7019 [doi]
AB  - Objective Depression is reported to be relatively common in idiopathic pulmonary 
      fibrosis (IPF) patients. Thus far, however, whether or not depression 
      independently determines the health-related quality of life (HRQOL) has not been 
      evaluated exclusively in IPF patients. We designed this study to identify 
      independent determinants of the St. George' s Respiratory Questionnaire (SGRQ) 
      score among various factors, including a depression scale, in IPF patients. 
      Methods We retrospectively analyzed consecutive subjects with IPF who completed a 
      systematic evaluation including pulmonary function tests, PaO(2) at rest, 
      6-minute walk test (6MWT), SGRQ, Baseline Dyspnea Index (BDI), and Hospital 
      Anxiety and Depression Scale (HADS). All eligible patients in the present study 
      had newly diagnosed IPF and had not received any prior treatments, such as 
      antidepressants, pirfenidone, corticosteroids, immunosuppressants, or long-term 
      oxygen therapy. Results The 121 patients with IPF included 99 men. On the SGRQ, 
      mild to moderate disturbance was observed in the total and each component score. 
      According to the HADS, 27 patients (22.3%) had borderline or definite depression. 
      In a univariate regression analysis, the forced vital capacity (FVC), diffusion 
      capacity of carbon monoxide (DLco), PaO(2) at rest, BDI, HADS for Anxiety 
      (HADS-A) and Depression (HADS-D), 6-minute walk distance (6MWD), and lowest 
      SpO(2) during the 6MWT were significantly correlated with the SGRQ total score. 
      In a stepwise multiple regression model, BDI, 6MWD, and HADS-D were selected as 
      independent determinants of the total SGRQ score. The total variance in this 
      model was 59% (p<0.001). Conclusion We concluded that depression was a 
      significant determinant of the HRQOL or health status in patients with IPF.
FAU - Matsuda, Toshiaki
AU  - Matsuda T
AD  - Department of Respiratory Medicine and Allergy, Tosei General Hospital, Japan.
AD  - Department of Respiratory Medicine, Nagoya University Graduate School of 
      Medicine, Japan.
FAU - Taniguchi, Hiroyuki
AU  - Taniguchi H
AD  - Department of Respiratory Medicine and Allergy, Tosei General Hospital, Japan.
FAU - Ando, Masahiko
AU  - Ando M
AD  - Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, 
      Japan.
FAU - Kondoh, Yasuhiro
AU  - Kondoh Y
AD  - Department of Respiratory Medicine and Allergy, Tosei General Hospital, Japan.
FAU - Kimura, Tomoki
AU  - Kimura T
AD  - Department of Respiratory Medicine and Allergy, Tosei General Hospital, Japan.
FAU - Kataoka, Kensuke
AU  - Kataoka K
AD  - Department of Respiratory Medicine and Allergy, Tosei General Hospital, Japan.
FAU - Nishimura, Koichi
AU  - Nishimura K
AD  - Department of Pulmonary Medicine, National Center for Geriatrics and Gerontology, 
      Japan.
FAU - Nishiyama, Osamu
AU  - Nishiyama O
AD  - Department of Respiratory Medicine and Allergology, Kindai University, Faculty of 
      Medicine, Japan.
FAU - Sakamoto, Koji
AU  - Sakamoto K
AD  - Department of Respiratory Medicine, Nagoya University Graduate School of 
      Medicine, Japan.
FAU - Hasegawa, Yoshinori
AU  - Hasegawa Y
AD  - Department of Respiratory Medicine, Nagoya University Graduate School of 
      Medicine, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170701
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
SB  - IM
MH  - Aged
MH  - Depression/*epidemiology
MH  - Female
MH  - Health Status
MH  - Humans
MH  - Idiopathic Pulmonary Fibrosis/*epidemiology/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - Quality of Life
MH  - Respiratory Function Tests
MH  - Retrospective Studies
MH  - *Severity of Illness Index
PMC - PMC5519463
OTO - NOTNLM
OT  - 6-minute walk test
OT  - depression
OT  - dyspnea
OT  - health status
OT  - idiopathic pulmonary fibrosis
EDAT- 2017/07/05 06:00
MHDA- 2018/01/06 06:00
PMCR- 2017/07/01
CRDT- 2017/07/05 06:00
PHST- 2017/07/05 06:00 [entrez]
PHST- 2017/07/05 06:00 [pubmed]
PHST- 2018/01/06 06:00 [medline]
PHST- 2017/07/01 00:00 [pmc-release]
AID - 10.2169/internalmedicine.56.7019 [doi]
PST - ppublish
SO  - Intern Med. 2017;56(13):1637-1644. doi: 10.2169/internalmedicine.56.7019. Epub 
      2017 Jul 1.