PMID- 28675761
OWN - NLM
STAT- MEDLINE
DCOM- 20180709
LR  - 20210109
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 73
IP  - 1
DP  - 2018 Jan
TI  - Estimating the causal effect of body mass index on hay fever, asthma and lung 
      function using Mendelian randomization.
PG  - 153-164
LID - 10.1111/all.13242 [doi]
AB  - BACKGROUND: Observational studies have shown that body mass index (BMI) is 
      positively associated with asthma. However, observational data are prone to 
      confounding and reverse causation. In Mendelian randomization, genetic variants 
      are used as unconfounded markers of exposures to examine causal effects. We 
      examined the causal effect of BMI on asthma, hay fever, allergic sensitization, 
      serum total immunoglobulin E (IgE), forced expiratory volume in one-second (FEV1) 
      and forced vital capacity (FVC). METHODS: We included 490 497 participants in the 
      observational and 162 124 participants in the genetic analyses. A genetic risk 
      score (GRS) was created using 26 BMI-associated single nucleotide polymorphisms 
      (SNPs). Results were pooled in meta-analyses and expressed as odds ratios (ORs) 
      or beta-estimates with 95% confidence interval (CI). RESULTS: The GRS was 
      significantly associated with asthma (OR=1.009; 95% CI: 1.004, 1.013), but not 
      with hay fever (OR= 0.998; 95% CI: 0.994, 1.002) or allergic sensitization 
      (OR=0.999; 95% CI: 0.986, 1.012) per BMI-increasing allele. The GRS was 
      significantly associated with decrease in FEV1: beta=-0.0012 (95% CI: -0.0019, 
      -0.0006) and FVC: beta=-0.0022 (95% CI: -0.0031, -0.0014) per BMI-increasing allele. 
      Effect sizes estimated by instrumental variable analyses were OR=1.07 (95% CI: 
      1.03, 1.10) for asthma, a 9 ml decrease in FEV1 (95% CI: 2.0-15 mL decrease) and 
      a 16 ml decrease in FVC (95% CI: 7.0-24 mL decrease) per 1 kg/m(2) higher BMI. 
      CONCLUSIONS: The results support the conclusion that increasing BMI is causally 
      related to higher prevalence of asthma and decreased lung function, but not with 
      hay fever or biomarkers of allergy.
CI  - (c) 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
FAU - Skaaby, T
AU  - Skaaby T
AUID- ORCID: 0000-0003-0031-5726
AD  - Research Centre for Prevention and Health, Centre for Health, Capital Region of 
      Denmark, Copenhagen, Denmark.
FAU - Taylor, A E
AU  - Taylor AE
AD  - MRC Integrative Epidemiology Unit (IEU), The University of Bristol, Bristol, UK.
AD  - UK Centre for Tobacco and Alcohol Studies, School of Experimental Psychology, 
      University of Bristol, Bristol, UK.
FAU - Thuesen, B H
AU  - Thuesen BH
AD  - Research Centre for Prevention and Health, Centre for Health, Capital Region of 
      Denmark, Copenhagen, Denmark.
FAU - Jacobsen, R K
AU  - Jacobsen RK
AD  - Research Centre for Prevention and Health, Centre for Health, Capital Region of 
      Denmark, Copenhagen, Denmark.
FAU - Friedrich, N
AU  - Friedrich N
AD  - Research Centre for Prevention and Health, Centre for Health, Capital Region of 
      Denmark, Copenhagen, Denmark.
AD  - Institute of Clinical Chemistry and Laboratory Medicine, University Medicine 
      Greifswald, Greifswald, Germany.
FAU - Mollehave, L T
AU  - Mollehave LT
AD  - Research Centre for Prevention and Health, Centre for Health, Capital Region of 
      Denmark, Copenhagen, Denmark.
FAU - Hansen, S
AU  - Hansen S
AD  - Research Centre for Prevention and Health, Centre for Health, Capital Region of 
      Denmark, Copenhagen, Denmark.
FAU - Larsen, S C
AU  - Larsen SC
AD  - Research unit for Dietary Studies, The Parker Institute, Frederiksberg and 
      Bispebjerg Hospitals, The Capital Region, Frederiksberg, Denmark.
FAU - Volker, U
AU  - Volker U
AD  - Interfaculty Institute for Genetics and Functional Genomics, University Medicine 
      and Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany.
FAU - Nauck, M
AU  - Nauck M
AD  - Institute of Clinical Chemistry and Laboratory Medicine, University Medicine 
      Greifswald, Greifswald, Germany.
FAU - Volzke, H
AU  - Volzke H
AD  - Institute for Community Medicine, University Medicine Greifswald, Greifswald, 
      Germany.
FAU - Hansen, T
AU  - Hansen T
AD  - Section on Metabolic Genetics, Faculty of Health and Medical Sciences, The Novo 
      Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, 
      Copenhagen, Denmark.
FAU - Pedersen, O
AU  - Pedersen O
AD  - Section on Metabolic Genetics, Faculty of Health and Medical Sciences, The Novo 
      Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, 
      Copenhagen, Denmark.
FAU - Jorgensen, T
AU  - Jorgensen T
AD  - Research Centre for Prevention and Health, Centre for Health, Capital Region of 
      Denmark, Copenhagen, Denmark.
AD  - Department of Public Health, Faculty of Health and Medical Sciences, University 
      of Copenhagen, Copenhagen, Denmark.
AD  - Faculty of Medicine, Aalborg University, Aalborg, Denmark.
FAU - Paternoster, L
AU  - Paternoster L
AD  - MRC Integrative Epidemiology Unit (IEU), The University of Bristol, Bristol, UK.
FAU - Munafo, M
AU  - Munafo M
AD  - MRC Integrative Epidemiology Unit (IEU), The University of Bristol, Bristol, UK.
AD  - UK Centre for Tobacco and Alcohol Studies, School of Experimental Psychology, 
      University of Bristol, Bristol, UK.
FAU - Grarup, N
AU  - Grarup N
AD  - Section on Metabolic Genetics, Faculty of Health and Medical Sciences, The Novo 
      Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, 
      Copenhagen, Denmark.
FAU - Linneberg, A
AU  - Linneberg A
AD  - Research Centre for Prevention and Health, Centre for Health, Capital Region of 
      Denmark, Copenhagen, Denmark.
AD  - Department of Clinical Experimental Research, Rigshospitalet, Glostrup, Denmark.
AD  - Department of Clinical Medicine, Faculty of Health and Medical Sciences, 
      University of Copenhagen, Copenhagen, Denmark.
LA  - eng
GR  - MC_QA137853/MRC_/Medical Research Council/United Kingdom
GR  - MC_UU_00011/7/MRC_/Medical Research Council/United Kingdom
GR  - MC_UU_12013/6/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20170802
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Asthma/epidemiology/*etiology/*physiopathology
MH  - *Body Mass Index
MH  - Female
MH  - Forced Expiratory Volume
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide
MH  - *Respiratory Function Tests
MH  - Rhinitis, Allergic, Seasonal/epidemiology/*etiology/*physiopathology
OTO - NOTNLM
OT  - allergic disease
OT  - allergic sensitization
OT  - asthma
OT  - hay fever
OT  - serum-specific IgE
EDAT- 2017/07/05 06:00
MHDA- 2018/07/10 06:00
CRDT- 2017/07/05 06:00
PHST- 2017/07/02 00:00 [accepted]
PHST- 2017/07/05 06:00 [pubmed]
PHST- 2018/07/10 06:00 [medline]
PHST- 2017/07/05 06:00 [entrez]
AID - 10.1111/all.13242 [doi]
PST - ppublish
SO  - Allergy. 2018 Jan;73(1):153-164. doi: 10.1111/all.13242. Epub 2017 Aug 2.