PMID- 28676006
OWN - NLM
STAT- MEDLINE
DCOM- 20190507
LR  - 20190507
IS  - 1874-6128 (Electronic)
IS  - 1874-6098 (Linking)
VI  - 11
IP  - 1
DP  - 2018
TI  - Carnosine Treatment Diminished Oxidative Stress and Glycation Products in Serum 
      and Tissues of D-Galactose-Treated Rats.
PG  - 10-15
LID - 10.2174/1871530317666170703123519 [doi]
AB  - BACKGROUND: Chronic administration of D-galactose (GAL) induces changes that 
      resemble natural aging in rodents. Oxidative stress and Advanced Glycation End 
      products (AGE) formation play a role in GAL-induced aging. Carnosine (CAR; 
      beta-alanyl-L-histidine) has antioxidant and anti-glycating actions and may be a 
      potential therapeutic agent in aging due to these properties. The effect of CAR 
      supplementation on AGE levels and oxidative stress parameters was investigated in 
      serum, liver and brain tissues in GAL-treated rats. METHODS: GAL (300 mg/kg; 
      s.c.; 5 days per week) alone or together with CAR (250 mg/kg/daily; i.p.; 5 days 
      per week) was applied to male rats for two months. AGE, Advanced Oxidized Protein 
      Products (AOPP), Protein Carbonyl (PC) and Malondialdehyde (MDA) levels together 
      with Reactive Oxygen Species (ROS) formation and Ferric Reducing Antioxidant 
      Power (FRAP) values were determined. RESULTS: GAL treatment elevated AGE levels, 
      ROS formation and protein and lipid oxidation products in serum and examined 
      tissues. CAR treatment was observed to decrease significantly glycooxidative 
      stress in serum, liver and brain tissues of GAL-treated rats. CONCLUSION: Our 
      results indicate that CAR may be useful for decreasing oxidative stress and 
      glycation products in GAL-induced aging model in rats.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.org.
FAU - Aydin, Fatih
AU  - Aydin F
AD  - Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
FAU - Kalaz, Esra Betul
AU  - Kalaz EB
AD  - Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
FAU - Kucukgergin, Canan
AU  - Kucukgergin C
AD  - Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
FAU - Coban, Jale
AU  - Coban J
AD  - Department of Biochemistry, Yeditepe University Medical Faculty, Istanbul, 
      Turkey.
FAU - Dogru-Abbasoglu, Semra
AU  - Dogru-Abbasoglu S
AD  - Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
FAU - Uysal, Mujdat
AU  - Uysal M
AD  - Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, 
      Istanbul, Turkey.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United Arab Emirates
TA  - Curr Aging Sci
JT  - Current aging science
JID - 101473576
RN  - 0 (Advanced Oxidation Protein Products)
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Glycation End Products, Advanced)
RN  - 0 (Reactive Oxygen Species)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 8HO6PVN24W (Carnosine)
RN  - X2RN3Q8DNE (Galactose)
SB  - IM
MH  - Advanced Oxidation Protein Products/blood
MH  - Age Factors
MH  - Aging/blood
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Biomarkers/blood
MH  - Brain/*drug effects/metabolism
MH  - Carnosine/*pharmacology
MH  - Galactose/*toxicity
MH  - Glycation End Products, Advanced/*blood
MH  - Lipid Peroxidation/drug effects
MH  - Liver/*drug effects/metabolism
MH  - Male
MH  - Malondialdehyde/blood
MH  - Oxidative Stress/*drug effects
MH  - Protein Carbonylation/drug effects
MH  - Rats, Wistar
MH  - Reactive Oxygen Species/blood
OTO - NOTNLM
OT  - D-Galactose
OT  - advanced glycation end products
OT  - brain
OT  - carnosine
OT  - liver
OT  - oxidative stress.
EDAT- 2017/07/06 06:00
MHDA- 2019/05/08 06:00
CRDT- 2017/07/06 06:00
PHST- 2017/04/17 00:00 [received]
PHST- 2017/06/13 00:00 [revised]
PHST- 2017/06/18 00:00 [accepted]
PHST- 2017/07/06 06:00 [pubmed]
PHST- 2019/05/08 06:00 [medline]
PHST- 2017/07/06 06:00 [entrez]
AID - CAS-EPUB-84437 [pii]
AID - 10.2174/1871530317666170703123519 [doi]
PST - ppublish
SO  - Curr Aging Sci. 2018;11(1):10-15. doi: 10.2174/1871530317666170703123519.