PMID- 28676262
OWN - NLM
STAT- MEDLINE
DCOM- 20170814
LR  - 20210920
IS  - 1879-3592 (Electronic)
IS  - 1383-5718 (Linking)
VI  - 820
DP  - 2017 Aug
TI  - Adaptive response in mouse bone marrow stromal cells exposed to 900MHz 
      radiofrequency fields: Impact of poly (ADP-ribose) polymerase (PARP).
PG  - 19-25
LID - S1383-5718(16)30354-0 [pii]
LID - 10.1016/j.mrgentox.2017.05.007 [doi]
AB  - This study examined whether non-ionizing radiofrequency fields (RF) exposure is 
      capable of inducing poly (ADP-ribose) polymerase-1 (PARP-1) in bone marrow 
      stromal cells (BMSCs) and whether it plays a role in RF-induced adaptive response 
      (AR). Bone marrow stromal cells (BMSCs) were exposed to 900MHz RF at 120muW/cm(2) 
      power flux density for 3h/day for 5days and then challenged with a genotoxic dose 
      of 1.5Gy gamma-radiation (GR). Some cells were also treated with 3-aminobenzamide 
      (3-AB, 2mM final concentration), a potent inhibitor of PARP-1. Un-exposed and 
      sham (SH)-exposed control cells as well as positive control cells exposed to 
      gamma radiation (GR) were included in the experiments. The expression of PARP-1 
      mRNA and its protein levels as well as single strand breaks in the DNA and the 
      kinetics of their repair were evaluated at several times after exposures. The 
      results indicated the following. (a) Cells exposed to RF alone showed 
      significantly increased PARP-1 mRNA expression and its protein levels compared 
      with those exposed to SH- and GR alone. (b) Treatment of RF-exposed cells with 
      3-AB had diminished such increase in PARP-1. (c) Cells exposed to RF+GR showed 
      significantly decreased genetic damage as well as faster kinetics of repair 
      compared with those exposed to GR alone. (d) Cells exposed to RF+3-AB+GR showed 
      no such decrease in genetic damage. Thus, the overall date suggested that 
      non-ionizing RF exposure was capable of inducing PARP-1 which has a role in 
      RF-induced AR.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - He, Qina
AU  - He Q
AD  - School of Public Health, Medical College of Soochow University, Suzhou Jiangsu 
      Province, People's Republic of China.
FAU - Zong, Lin
AU  - Zong L
AD  - School of Public Health, Medical College of Soochow University, Suzhou Jiangsu 
      Province, People's Republic of China.
FAU - Sun, Yulong
AU  - Sun Y
AD  - School of Public Health, Medical College of Soochow University, Suzhou Jiangsu 
      Province, People's Republic of China.
FAU - Vijayalaxmi
AU  - Vijayalaxmi
AD  - Deparment of Radiology, University of Texas Health Science Center, San Antonio, 
      TX, USA.
FAU - Prihoda, Thomas J
AU  - Prihoda TJ
AD  - Deparment of Pathology, University of Texas Health Science Center, San Antonio, 
      TX, USA.
FAU - Tong, Jian
AU  - Tong J
AD  - School of Public Health, Medical College of Soochow University, Suzhou Jiangsu 
      Province, People's Republic of China.
FAU - Cao, Yi
AU  - Cao Y
AD  - School of Public Health, Medical College of Soochow University, Suzhou Jiangsu 
      Province, People's Republic of China. Electronic address: yicao@suda.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170517
PL  - Netherlands
TA  - Mutat Res Genet Toxicol Environ Mutagen
JT  - Mutation research. Genetic toxicology and environmental mutagenesis
JID - 101632149
RN  - 0 (RNA, Messenger)
RN  - EC 2.4.2.30 (Parp1 protein, mouse)
RN  - EC 2.4.2.30 (Poly (ADP-Ribose) Polymerase-1)
SB  - IM
MH  - Adaptation, Physiological/genetics/*radiation effects
MH  - Animals
MH  - Bone Marrow Cells/pathology/*radiation effects
MH  - Cells, Cultured
MH  - Comet Assay
MH  - *DNA Breaks, Single-Stranded
MH  - *DNA Repair
MH  - Enzyme Induction
MH  - Gamma Rays/adverse effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Poly (ADP-Ribose) Polymerase-1/*biosynthesis/genetics
MH  - RNA, Messenger/genetics/metabolism
MH  - Radio Waves/*adverse effects
MH  - Stromal Cells/pathology/*radiation effects
OTO - NOTNLM
OT  - Adaptive response
OT  - DNA damage
OT  - Mouse bone marrow stromal cells
OT  - Poly (ADP-ribose) polymerase-1
OT  - Radiofrequency fields
EDAT- 2017/07/06 06:00
MHDA- 2017/08/15 06:00
CRDT- 2017/07/06 06:00
PHST- 2016/10/26 00:00 [received]
PHST- 2017/04/18 00:00 [revised]
PHST- 2017/05/11 00:00 [accepted]
PHST- 2017/07/06 06:00 [entrez]
PHST- 2017/07/06 06:00 [pubmed]
PHST- 2017/08/15 06:00 [medline]
AID - S1383-5718(16)30354-0 [pii]
AID - 10.1016/j.mrgentox.2017.05.007 [doi]
PST - ppublish
SO  - Mutat Res Genet Toxicol Environ Mutagen. 2017 Aug;820:19-25. doi: 
      10.1016/j.mrgentox.2017.05.007. Epub 2017 May 17.