PMID- 28677093
OWN - NLM
STAT- MEDLINE
DCOM- 20181002
LR  - 20211204
IS  - 1573-675X (Electronic)
IS  - 1360-8185 (Linking)
VI  - 22
IP  - 9
DP  - 2017 Sep
TI  - Structural aspects of transglutaminase 2: functional, structural, and regulatory 
      diversity.
PG  - 1057-1068
LID - 10.1007/s10495-017-1396-9 [doi]
AB  - Transglutaminase 2 (TG2) is a multi-functional protein that has both protein 
      cross-linking and guanosine 5'-triphosphate (GTP) hydrolysis activities. The 
      activities of this protein are controlled by many cellular factors, including 
      calcium (Ca(2+)) and GTP, and have been implicated in several physiological 
      activities, including apoptosis, angiogenesis, wound healing, cellular 
      differentiation, neuronal regeneration, and bone development. TG2 is linked to 
      many human diseases such as inflammatory disease, celiac disease, 
      neurodegenerative disease, diabetes, tissue fibrosis, and various cancers and is 
      one of the most dynamic enzymes in terms of its functions, structures, and 
      regulatory mechanisms. The aim of this review was to summarize the functional, 
      structural, and regulatory diversity of TG2, with a particular focus on the 
      structure of TG2.
FAU - Lee, Chang Sup
AU  - Lee CS
AD  - College of Pharmacy and Research Institute of Pharmaceutical Science, Gyeongsang 
      National University, Jinju, 52828, South Korea.
FAU - Park, Hyun Ho
AU  - Park HH
AD  - School of Chemistry and Biochemistry and Graduate School of Biochemistry, 
      Yeungnam University, Gyeongsan, South Korea. hyunho@ynu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Apoptosis
JT  - Apoptosis : an international journal on programmed cell death
JID - 9712129
RN  - 0 (Multifunctional Enzymes)
RN  - EC 2.3.2.13 (Protein Glutamine gamma Glutamyltransferase 2)
RN  - EC 2.3.2.13 (Transglutaminases)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Calcium/metabolism
MH  - Enzyme Activation
MH  - GTP-Binding Proteins/*chemistry/metabolism/*physiology
MH  - Humans
MH  - Molecular Structure
MH  - Multifunctional Enzymes/chemistry/metabolism
MH  - Protein Glutamine gamma Glutamyltransferase 2
MH  - Structure-Activity Relationship
MH  - Transglutaminases/*chemistry/metabolism/*physiology
OTO - NOTNLM
OT  - Apoptosis
OT  - Cross-linking
OT  - Inhibitor
OT  - Structure
OT  - Transglutaminase 2
EDAT- 2017/07/06 06:00
MHDA- 2018/10/03 06:00
CRDT- 2017/07/06 06:00
PHST- 2017/07/06 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
PHST- 2017/07/06 06:00 [entrez]
AID - 10.1007/s10495-017-1396-9 [pii]
AID - 10.1007/s10495-017-1396-9 [doi]
PST - ppublish
SO  - Apoptosis. 2017 Sep;22(9):1057-1068. doi: 10.1007/s10495-017-1396-9.