PMID- 28677323
OWN - NLM
STAT- MEDLINE
DCOM- 20180515
LR  - 20190228
IS  - 1474-9726 (Electronic)
IS  - 1474-9718 (Print)
IS  - 1474-9718 (Linking)
VI  - 16
IP  - 5
DP  - 2017 Oct
TI  - Caloric restriction impacts plasma microRNAs in rhesus monkeys.
PG  - 1200-1203
LID - 10.1111/acel.12636 [doi]
AB  - Caloric restriction (CR) is one of the most robust interventions shown to delay 
      aging in diverse species, including rhesus monkeys (Macaca mulatta). 
      Identification of factors involved in CR brings a promise of translatability to 
      human health and aging. Here, we show that CR induced a profound change in 
      abundance of circulating microRNAs (miRNAs) linked to growth and insulin 
      signaling pathway, suggesting that miRNAs are involved in CR's mechanisms of 
      action in primates. Deep sequencing of plasma RNA extracts enriched for short 
      species revealed a total of 243 unique species of miRNAs including 47 novel 
      species. Approximately 70% of the plasma miRNAs detected were conserved between 
      rhesus monkeys and humans. CR induced or repressed 24 known and 10 novel miRNA 
      species. Regression analysis revealed correlations between bodyweight, adiposity, 
      and insulin sensitivity for 10 of the CR-regulated known miRNAs. Sequence 
      alignment and target identification for these 10 miRNAs identify a role in 
      signaling downstream of the insulin receptor. The highly abundant miR-125a-5p 
      correlated positively with adiposity and negatively with insulin sensitivity and 
      was negatively regulated by CR. Putative target pathways of CR-associated miRNAs 
      were highly enriched for growth and insulin signaling that have previously been 
      implicated in delayed aging. Clustering analysis further pointed to CR-induced 
      miRNA regulation of ribosomal, mitochondrial, and spliceosomal pathways. These 
      data are consistent with a model where CR recruits miRNA-based homeostatic 
      mechanisms to coordinate a program of delayed aging.
CI  - (c) 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley 
      & Sons Ltd.
FAU - Schneider, Augusto
AU  - Schneider A
AD  - Faculdade de Nutricao, Universidade Federal de Pelotas, Pelotas-RS, 96010-610, 
      Brazil.
AD  - College of Medicine, Burnett School of Biomedical Sciences, University of Central 
      Florida, Orlando, FL, 32827, USA.
FAU - Dhahbi, Joseph M
AU  - Dhahbi JM
AD  - College of Medicine, California University of Science and Medicine, Colton, CA, 
      92324, USA.
FAU - Atamna, Hani
AU  - Atamna H
AD  - College of Medicine, California University of Science and Medicine, Colton, CA, 
      92324, USA.
FAU - Clark, Josef P
AU  - Clark JP
AD  - Department of Medicine, University of Wisconsin, Madison, WI, 53705, USA.
FAU - Colman, Ricki J
AU  - Colman RJ
AD  - Wisconsin National Primate Research Center, Madison, WI, 53706, USA.
FAU - Anderson, Rozalyn M
AU  - Anderson RM
AD  - Department of Medicine, University of Wisconsin, Madison, WI, 53705, USA.
AD  - GRECC, William S. Middleton Memorial Veterans Hospital, Madison, WI, 53705, USA.
LA  - eng
GR  - P50 AG033514/AG/NIA NIH HHS/United States
GR  - R01 AG040178/AG/NIA NIH HHS/United States
GR  - R56 AG047358/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20170705
PL  - England
TA  - Aging Cell
JT  - Aging cell
JID - 101130839
RN  - 0 (MicroRNAs)
RN  - EC 2.7.10.1 (Receptor, Insulin)
SB  - IM
MH  - Adiposity
MH  - Aging/*genetics/metabolism
MH  - Animals
MH  - Caloric Restriction/*methods
MH  - Conserved Sequence
MH  - *Gene Expression Regulation, Developmental
MH  - Humans
MH  - Insulin Resistance/*genetics
MH  - Macaca mulatta
MH  - Male
MH  - MicroRNAs/blood/classification/*genetics
MH  - Mitochondria/genetics/metabolism
MH  - Principal Component Analysis
MH  - Receptor, Insulin/genetics/metabolism
MH  - Ribosomes/genetics/metabolism
MH  - Signal Transduction
MH  - Spliceosomes/genetics/metabolism
PMC - PMC5595684
OTO - NOTNLM
OT  - aging
OT  - caloric restriction
OT  - miR-125a-5p
OT  - microRNA
OT  - rhesus monkeys
EDAT- 2017/07/06 06:00
MHDA- 2018/05/16 06:00
PMCR- 2017/10/01
CRDT- 2017/07/06 06:00
PHST- 2017/06/01 00:00 [accepted]
PHST- 2017/07/06 06:00 [pubmed]
PHST- 2018/05/16 06:00 [medline]
PHST- 2017/07/06 06:00 [entrez]
PHST- 2017/10/01 00:00 [pmc-release]
AID - ACEL12636 [pii]
AID - 10.1111/acel.12636 [doi]
PST - ppublish
SO  - Aging Cell. 2017 Oct;16(5):1200-1203. doi: 10.1111/acel.12636. Epub 2017 Jul 5.