PMID- 28677920
OWN - NLM
STAT- MEDLINE
DCOM- 20190705
LR  - 20200306
IS  - 1613-6829 (Electronic)
IS  - 1613-6810 (Print)
IS  - 1613-6810 (Linking)
VI  - 13
IP  - 33
DP  - 2017 Sep
TI  - The Genetic Heterogeneity among Different Mouse Strains Impacts the Lung Injury 
      Potential of Multiwalled Carbon Nanotubes.
LID - 10.1002/smll.201700776 [doi]
AB  - Genetic variation constitutes an important variable impacting the susceptibility 
      to inhalable toxic substances and air pollutants, as reflected by epidemiological 
      studies in humans and differences among animal strains. While multiwalled carbon 
      nanotubes (MWCNTs) are capable of causing lung fibrosis in rodents, it is unclear 
      to what extent the genetic variation in different mouse strains influence the 
      outcome. Four inbred mouse strains, including C57Bl/6, Balb/c, NOD/ShiLtJ, and 
      A/J, to test the pro-fibrogenic effects of a library of MWCNTs in vitro and in 
      vivo are chosen. Ex vivo analysis of IL-1beta production in bone marrow-derived 
      macrophages (BMDMs) as molecular initiating event (MIE) is performed. The order 
      of cytokine production (Balb/c > A/J > C57Bl/6 > NOD/ShiLtJ) in BMDMs is also 
      duplicated during assessment of IL-1beta production in the bronchoalveolar lavage 
      fluid of the same mouse strains 40 h after oropharyngeal instillation of a 
      representative MWCNT. Animal test after 21 d also confirms a similar hierarchy in 
      TGF-beta1 production and collagen deposition in the lung. Statistical analysis 
      confirms a correlation between IL-1beta production in BMDM and the lung fibrosis. 
      All considered, these data demonstrate that genetic background indeed plays a 
      major role in determining the pro-fibrogenic response to MWCNTs in the lung.
CI  - (c) 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Wang, Xiang
AU  - Wang X
AD  - Division of NanoMedicine, University of California, Los Angeles, CA, 90095, USA.
AD  - California NanoSystems Institute, University of California, Los Angeles, CA, 
      90095, USA.
FAU - Liao, Yu-Pei
AU  - Liao YP
AD  - Division of NanoMedicine, University of California, Los Angeles, CA, 90095, USA.
FAU - Telesca, Donatello
AU  - Telesca D
AD  - Department of Biostatistics, University of California, Los Angeles, CA, 90095, 
      USA.
FAU - Chang, Chong Hyun
AU  - Chang CH
AD  - California NanoSystems Institute, University of California, Los Angeles, CA, 
      90095, USA.
FAU - Xia, Tian
AU  - Xia T
AD  - Division of NanoMedicine, University of California, Los Angeles, CA, 90095, USA.
AD  - California NanoSystems Institute, University of California, Los Angeles, CA, 
      90095, USA.
FAU - Nel, Andre E
AU  - Nel AE
AD  - Division of NanoMedicine, University of California, Los Angeles, CA, 90095, USA.
AD  - California NanoSystems Institute, University of California, Los Angeles, CA, 
      90095, USA.
LA  - eng
GR  - R01 ES022698/ES/NIEHS NIH HHS/United States
GR  - U01 ES027237/ES/NIEHS NIH HHS/United States
GR  - U19 ES019528/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20170705
PL  - Germany
TA  - Small
JT  - Small (Weinheim an der Bergstrasse, Germany)
JID - 101235338
RN  - 0 (Acids)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Nanotubes, Carbon)
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Acids/chemistry
MH  - Analysis of Variance
MH  - Animals
MH  - Chemical Phenomena
MH  - Fibrosis
MH  - *Genetic Heterogeneity
MH  - Humans
MH  - Interleukin-1beta/metabolism
MH  - Lung Injury/*genetics/pathology
MH  - Macrophages/metabolism
MH  - Mice, Inbred Strains
MH  - Nanotubes, Carbon/*chemistry/ultrastructure
MH  - THP-1 Cells
MH  - Transforming Growth Factor beta1/metabolism
PMC - PMC5581261
MID - NIHMS896992
OTO - NOTNLM
OT  - BMDM
OT  - MWCNT
OT  - lung fibrosis
OT  - mouse strain
EDAT- 2017/07/06 06:00
MHDA- 2019/07/06 06:00
PMCR- 2018/09/01
CRDT- 2017/07/06 06:00
PHST- 2017/03/09 00:00 [received]
PHST- 2017/05/15 00:00 [revised]
PHST- 2017/07/06 06:00 [pubmed]
PHST- 2019/07/06 06:00 [medline]
PHST- 2017/07/06 06:00 [entrez]
PHST- 2018/09/01 00:00 [pmc-release]
AID - 10.1002/smll.201700776 [doi]
PST - ppublish
SO  - Small. 2017 Sep;13(33):10.1002/smll.201700776. doi: 10.1002/smll.201700776. Epub 
      2017 Jul 5.