PMID- 28678733
OWN - NLM
STAT- MEDLINE
DCOM- 20190103
LR  - 20220317
IS  - 1862-278X (Electronic)
IS  - 0013-5585 (Linking)
VI  - 63
IP  - 3
DP  - 2018 Jun 27
TI  - Preparation, characterization and blood compatibility assessment of a novel 
      electrospun nanocomposite comprising polyurethane and ayurvedic-indhulekha oil 
      for tissue engineering applications.
PG  - 245-253
LID - 10.1515/bmt-2017-0022 [doi]
AB  - Electrospun polyurethane based nanocomposite scaffolds were fabricated by mixing 
      with indhulekha oil. Scanning electron microscope (SEM) portrayed the nanofibrous 
      nature of the composite and the average diameters of the composite scaffold were 
      smaller than the pristine scaffolds. The fabricated scaffold was found to be 
      hydrophobic (114 degrees ) due to the inclusion of indhulekha oil, which was displayed in 
      contact angle measurement analysis. The fourier transform infrared spectroscopy 
      (FTIR) results indicated that the indhulekha oil was dispersed in PU matrix 
      identified by formation of hydrogen bond and peak shifting of CH group. The 
      PU/indhulekha oil nanocomposite exhibits a higher decomposition onset temperature 
      and also residual weight percentage at 900 degrees C was more compared to the pure PU. 
      Surface roughness was found to be increased in the composite compared to the 
      pristine PU as indicated by the atomic force microscopy (AFM) analysis. In order 
      to investigate the blood compatibility of electrospun nanocomposites the 
      activated partial thromboplastin time (APTT) assay, prothrombin time (PT) assay 
      and hemolytic assay were performed. The blood compatibility results APTT and PT 
      revealed that the developed nanocomposites demonstrated delayed clotting time 
      indicating the anticoagulant nature of the composite in comparison with the 
      pristine PU. Further, it was also observed that the hemolytic index of 
      nanocomposites was reduced compared to pure PU suggesting the non-hemolytic 
      nature of the fabricated scaffold. Hence, the fabricated nanocomposites might be 
      considered as a potent substitute for scaffolding damaged tissue due to their 
      inherent physicochemical and blood compatibility properties.
FAU - Ayyar, Manikandan
AU  - Ayyar M
AD  - Department of Chemistry, Bharath Institute of Higher Education and Research, 
      Bharath University, Chennai 600073, Tamil Nadu, India.
FAU - Mani, Mohan Prasath
AU  - Mani MP
AD  - IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical 
      Engineering, Universiti Teknologi Malaysia, Skudai 81300, Johor,Malaysia.
FAU - Jaganathan, Saravana Kumar
AU  - Jaganathan SK
AD  - IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical 
      Engineering, Universiti Teknologi Malaysia, Skudai 81300, Johor,Malaysia.
AD  - Department for Management of Science and Technology Development, Ton Duc Thang 
      University, Ho Chi Minh City, Vietnam.
AD  - Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
FAU - Rathanasamy, Rajasekar
AU  - Rathanasamy R
AD  - Department of Mechanical Engineering, Kongu Engineering college, Erode, Tamil 
      Nadu,India.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Biomed Tech (Berl)
JT  - Biomedizinische Technik. Biomedical engineering
JID - 1262533
RN  - 0 (Biocompatible Materials)
RN  - 0 (Oils)
RN  - 0 (Polyurethanes)
SB  - IM
MH  - Biocompatible Materials/*chemistry
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Nanocomposites
MH  - Oils/*chemistry
MH  - Polyurethanes/*chemistry
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Tissue Engineering/*methods
MH  - Tissue Scaffolds/*chemistry
OTO - NOTNLM
OT  - hemocompatibile
OT  - indhulekha oil
OT  - nanocomposites
OT  - polyurethane
OT  - tissue engineering
EDAT- 2017/07/06 06:00
MHDA- 2019/01/04 06:00
CRDT- 2017/07/06 06:00
PHST- 2017/03/03 00:00 [received]
PHST- 2017/05/24 00:00 [accepted]
PHST- 2017/07/06 06:00 [pubmed]
PHST- 2019/01/04 06:00 [medline]
PHST- 2017/07/06 06:00 [entrez]
AID - /j/bmte.ahead-of-print/bmt-2017-0022/bmt-2017-0022.xml [pii]
AID - 10.1515/bmt-2017-0022 [doi]
PST - ppublish
SO  - Biomed Tech (Berl). 2018 Jun 27;63(3):245-253. doi: 10.1515/bmt-2017-0022.