PMID- 28679886
OWN - NLM
STAT- MEDLINE
DCOM- 20180420
LR  - 20181202
IS  - 1879-8365 (Electronic)
IS  - 0926-9630 (Linking)
VI  - 238
DP  - 2017
TI  - The Artificial Pancreas: Reducing Safety Risk via Intra-Peritoneal Insulin 
      Delivery.
PG  - 56-59
AB  - The Artificial Pancreas is a medical device, currently in development, that aims 
      to provide automatic regulation of blood glucose (BG) levels in ambulatory type 1 
      diabetes mellitus sufferers. The most popular approach utilises subcutaneous (SC) 
      continuous glucose monitoring (CGM) combined with SC insulin injection controlled 
      by a Model Predictive Control (MPC) algorithm. From a safety risk perspective 
      problematic elements include the performance robustness of the CGM and the need 
      for a pre-meal insulin bolus to provide satisfactory post prandial BG regulation. 
      This contribution presents preliminary in silico studies which indicate that the 
      use of an alternative approach to insulin delivery - intra-peritoneal (IP) 
      infusion - could provide a similar level of BG regulation (as obtained with SC 
      delivery), without the need for the pre-meal bolus. This simplified control 
      architecture would remove the patient safety risk related to the administration 
      (or not) of pre-meal bolus.
FAU - Jones, Richard W
AU  - Jones RW
AD  - Department of Computer Science, University of York, U.K.
FAU - Gianni, Francesco
AU  - Gianni F
AD  - Controls and Data Services, Birmingham, U.K.
FAU - Despotou, Georgios
AU  - Despotou G
AD  - Institute of Digital Healthcare WMG, University of Warwick, U.K.
FAU - Katzis, Konstantinos
AU  - Katzis K
AD  - Department of Computer Science and Engineering, European University Cyprus, CY.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Stud Health Technol Inform
JT  - Studies in health technology and informatics
JID - 9214582
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
MH  - Blood Glucose
MH  - *Blood Glucose Self-Monitoring
MH  - Diabetes Mellitus, Type 1/*drug therapy
MH  - Humans
MH  - Hypoglycemic Agents/*administration & dosage
MH  - Insulin
MH  - *Insulin Infusion Systems
MH  - *Pancreas, Artificial
OTO - NOTNLM
OT  - Artificial pancreas
OT  - intra-peritoneal insulin delivery
OT  - model predictive control
OT  - pre-meal bolus
EDAT- 2017/07/07 06:00
MHDA- 2018/04/21 06:00
CRDT- 2017/07/07 06:00
PHST- 2017/07/07 06:00 [entrez]
PHST- 2017/07/07 06:00 [pubmed]
PHST- 2018/04/21 06:00 [medline]
PST - ppublish
SO  - Stud Health Technol Inform. 2017;238:56-59.