PMID- 28680339
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1426-3912 (Print)
IS  - 1644-4124 (Electronic)
IS  - 1426-3912 (Linking)
VI  - 42
IP  - 1
DP  - 2017
TI  - Exceptional manifestation of polyautoimmunity in a very young girl - a case 
      report.
PG  - 107-110
LID - 10.5114/ceji.2017.67324 [doi]
AB  - Polyautoimmunity is defined as the presence of more than one autoimmune disease 
      in a single patient. The exact pathogenic mechanisms responsible for the 
      coexistence of distinct autoimmune diseases within an individual have not been 
      clearly explained. We report a case of a very young girl with the extremely rare 
      co-existence of four distinct autoimmune diseases i.e. juvenile idiopathic 
      arthritis, type 1 diabetes mellitus, coeliac disease and autoimmune hepatitis, 
      recognized based on validated international classification criteria. The best to 
      our knowledge there has been no case reporting coexistence of these particular 
      four disorders in an individual. Moreover, all these diseases occurred during 
      first three years of life, which also cause that case unique. Molecular studies 
      of human leukocyte antigen (HLA) class II in our patient showed the presence of 
      the HLA DRB1*01, HLA DRB1*03, HLA DQB1*02, HLA DQB1*05 molecules, which may 
      suggest immunogenetic links between those autoimmune diseases. The presented case 
      highlights the importance of active screening for other autoimmune diseases, if a 
      patient with one autoimmune disease manifests with new or nonspecific symptoms.
FAU - Mroczkowska-Juchkiewicz, Agnieszka
AU  - Mroczkowska-Juchkiewicz A
AD  - Department of Paediatrics, Medical University of Lublin, Lublin, Poland.
FAU - Postepski, Jacek
AU  - Postepski J
AD  - Department of Paediatric Pulmonology and Rheumatology, Medical University of 
      Lublin, Lublin, Poland.
FAU - Olesinska, Edyta
AU  - Olesinska E
AD  - Department of Paediatric Pulmonology and Rheumatology, Medical University of 
      Lublin, Lublin, Poland.
FAU - Krawiec, Paulina
AU  - Krawiec P
AD  - Department of Paediatrics, Medical University of Lublin, Lublin, Poland.
FAU - Pac-Kozuchowska, Elzbieta
AU  - Pac-Kozuchowska E
AD  - Department of Paediatrics, Medical University of Lublin, Lublin, Poland.
LA  - eng
PT  - Case Reports
DEP - 20170508
PL  - Poland
TA  - Cent Eur J Immunol
JT  - Central-European journal of immunology
JID - 9702239
PMC - PMC5470620
OTO - NOTNLM
OT  - autoimmune hepatitis
OT  - celiac disease
OT  - juvenile idiopathic arthritis
OT  - polyautoimmunity
OT  - type 1 diabetes
COIS- The authors declare no conflict of interest.
EDAT- 2017/07/07 06:00
MHDA- 2017/07/07 06:01
PMCR- 2017/01/01
CRDT- 2017/07/07 06:00
PHST- 2016/03/30 00:00 [received]
PHST- 2016/05/13 00:00 [accepted]
PHST- 2017/07/07 06:00 [entrez]
PHST- 2017/07/07 06:00 [pubmed]
PHST- 2017/07/07 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 29852 [pii]
AID - 10.5114/ceji.2017.67324 [doi]
PST - ppublish
SO  - Cent Eur J Immunol. 2017;42(1):107-110. doi: 10.5114/ceji.2017.67324. Epub 2017 
      May 8.