PMID- 28681311
OWN - NLM
STAT- MEDLINE
DCOM- 20180730
LR  - 20181113
IS  - 1590-3478 (Electronic)
IS  - 1590-1874 (Linking)
VI  - 38
IP  - 9
DP  - 2017 Sep
TI  - Low plasma BDNF is not a biomarker for cognitive dysfunction in elderly T2DM 
      patients.
PG  - 1691-1696
LID - 10.1007/s10072-017-3048-9 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a known cause of cognitive dysfunction, and 
      brain-derived neurotrophic factor (BDNF) is a key protein in promoting memory 
      growth and survival of neurons. However, the relationship between plasma BDNF and 
      diabetic cognitive dysfunction is still elusive. A total of 89 patients over 
      60 years with T2DM and 40 well-matched health controls were enrolled. All 
      participants received a set of multi-dimensional neuropsychological tests for the 
      cognitive assessment. The subjects were divided into amnesic mild cognitive 
      impairment (aMCI) and non-aMCI groups. An enzyme-linked immunosorbent assay 
      (ELISA) was used to measure plasma BDNF concentrations for all subjects. No 
      significant difference was found between T2DM patients and healthy control in 
      MMSE scores. The T2DM patients performed significantly worse in four cognitive 
      domains (including episodic memory, executive function, visuospatial function, 
      and information processing speed) compared with the controls (all p < 0.05). The 
      prevalence of aMCI in T2DM population was higher [OR = 4.032 (1.536~10.582), 
      37/89-6/40]. Additionally, the plasma concentration of BDNF in T2DM patients was 
      significantly lower than that in controls (p < 0.01). However, no significant 
      correlation was found between plasma BDNF and cognitive function in T2DM. Our 
      results suggested that T2DM have a higher prevalence of cognitive impairment. The 
      plasma BDNF concentration in T2DM patients was significantly lower than that in 
      controls, but low BDNF was not a biomarker for cognitive dysfunction in T2DM 
      patients.
FAU - Ren, Qing-Guo
AU  - Ren QG
AUID- ORCID: 0000-0001-9758-5268
AD  - Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, 
      Southeast University, Nanjing, China.
FAU - Chang, Jing-Hao
AU  - Chang JH
AD  - Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, 
      Southeast University, Nanjing, China.
FAU - Lu, Wan-Jun
AU  - Lu WJ
AD  - Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, 
      Southeast University, Nanjing, China.
FAU - Gong, Wei-Gang
AU  - Gong WG
AD  - Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, 
      Southeast University, Nanjing, China.
FAU - Zhou, Hong
AU  - Zhou H
AD  - Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, 
      Southeast University, Nanjing, China. zzhouhongg2015@sina.com.
LA  - eng
GR  - 81271218/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20170705
PL  - Italy
TA  - Neurol Sci
JT  - Neurological sciences : official journal of the Italian Neurological Society and 
      of the Italian Society of Clinical Neurophysiology
JID - 100959175
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Cognition
MH  - Cognitive Dysfunction/*blood/epidemiology/*etiology
MH  - Diabetes Mellitus, Type 2/*blood/*complications/epidemiology/psychology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Prevalence
OTO - NOTNLM
OT  - Amnesic mild cognitive impairment
OT  - Brain-derived neurotrophic factor
OT  - Cognitive function
OT  - Type 2 diabetes mellitus
EDAT- 2017/07/07 06:00
MHDA- 2018/07/31 06:00
CRDT- 2017/07/07 06:00
PHST- 2017/02/21 00:00 [received]
PHST- 2017/06/21 00:00 [accepted]
PHST- 2017/07/07 06:00 [pubmed]
PHST- 2018/07/31 06:00 [medline]
PHST- 2017/07/07 06:00 [entrez]
AID - 10.1007/s10072-017-3048-9 [pii]
AID - 10.1007/s10072-017-3048-9 [doi]
PST - ppublish
SO  - Neurol Sci. 2017 Sep;38(9):1691-1696. doi: 10.1007/s10072-017-3048-9. Epub 2017 
      Jul 5.