PMID- 28681637
OWN - NLM
STAT- MEDLINE
DCOM- 20190726
LR  - 20190726
IS  - 1932-2968 (Electronic)
IS  - 1932-2968 (Linking)
VI  - 12
IP  - 1
DP  - 2018 Jan
TI  - Persistence With Oral Antihyperglycemic Drugs in Type 2 Diabetes Mellitus 
      Patients With Dementia in Germany.
PG  - 140-144
LID - 10.1177/1932296817719090 [doi]
AB  - BACKGROUND: The aim of this study was to analyze the persistence with oral 
      antihyperglycemic drugs in type 2 diabetes mellitus (T2DM) patients with dementia 
      in Germany. METHODS: This study included adults with T2DM who were treated with 
      oral antihyperglycemic drugs and were diagnosed with dementia in 1262 German 
      general practices between January 2013 and December 2015 (index date). Dementia 
      cases were matched (1:1) to controls without dementia by age, gender, type of 
      practice, type of residence, physician, and initial antihyperglycemic therapy, 
      using a propensity score method. The primary outcome of the study was the rate of 
      persistence with oral antihyperglycemic drugs in dementia cases and controls 
      without dementia in the year following the index date. Persistence was estimated 
      as therapy time without treatment discontinuation, which was defined as at least 
      90 days without oral antihyperglycemic therapy. Cox regressions were used to 
      determine the impact of dementia on persistence with oral antihyperglycemic 
      treatment in the entire population and in different subgroups. RESULTS: This 
      study included 848 T2DM patients with dementia and 848 T2DM patients without 
      dementia. In the dementia group, 39.2% of patients were men, while the control 
      group included 40.8% men. After 12 months of follow-up, 72.7% of dementia cases 
      and 71.4% of controls without dementia were persistent ( P = .291). No 
      significant association was found between dementia and persistence with oral 
      antihyperglycemic drugs in the entire population and in different subgroups (HR 
      ranging from 0.84 to 1.25). CONCLUSIONS: Dementia did not have a significant 
      impact on persistence with oral antihyperglycemic drugs in T2DM patients in 
      Germany.
FAU - Jacob, Louis
AU  - Jacob L
AD  - 1 Faculty of Medicine, University of Paris 5, Paris, France.
FAU - Adam-Schnepf, Leonie
AU  - Adam-Schnepf L
AD  - 2 Faculty of Medicine, University of Marburg, Marburg, Germany.
FAU - Kostev, Karel
AU  - Kostev K
AD  - 3 Epidemiology, QuintilesIMS, Frankfurt, Germany.
LA  - eng
PT  - Journal Article
DEP - 20170706
PL  - United States
TA  - J Diabetes Sci Technol
JT  - Journal of diabetes science and technology
JID - 101306166
RN  - 0 (Hypoglycemic Agents)
MH  - Administration, Oral
MH  - Aged
MH  - Aged, 80 and over
MH  - Dementia/*complications
MH  - Diabetes Mellitus, Type 2/complications/*drug therapy
MH  - Female
MH  - Germany
MH  - Humans
MH  - Hypoglycemic Agents/administration & dosage/*therapeutic use
MH  - Male
MH  - *Medication Adherence
MH  - Middle Aged
MH  - Retrospective Studies
PMC - PMC5761980
OTO - NOTNLM
OT  - Germany
OT  - dementia
OT  - oral antihyperglycemic drugs
OT  - persistence
OT  - type 2 diabetes mellitus
COIS- Declaration of Conflicting Interests: The author(s) declared the following 
      potential conflicts of interest with respect to the research, authorship, and/or 
      publication of this article: LJ and LAS declare to have no potential conflicts of 
      interest with respect to the research, authorship, and/or publication of this 
      article. Although KK is an employee of QuintilesIMS, he has no conflicts of 
      interest with respect to the research, authorship, and publication of this 
      article.
EDAT- 2017/07/07 06:00
MHDA- 2019/07/28 06:00
PMCR- 2018/07/06
CRDT- 2017/07/07 06:00
PHST- 2017/07/07 06:00 [pubmed]
PHST- 2019/07/28 06:00 [medline]
PHST- 2017/07/07 06:00 [entrez]
PHST- 2018/07/06 00:00 [pmc-release]
AID - 10.1177_1932296817719090 [pii]
AID - 10.1177/1932296817719090 [doi]
PST - ppublish
SO  - J Diabetes Sci Technol. 2018 Jan;12(1):140-144. doi: 10.1177/1932296817719090. 
      Epub 2017 Jul 6.