PMID- 28681821
OWN - NLM
STAT- MEDLINE
DCOM- 20180316
LR  - 20180316
IS  - 1998-3646 (Electronic)
IS  - 0255-0857 (Linking)
VI  - 35
IP  - 2
DP  - 2017 Apr-Jun
TI  - Risk factors and frequency of tuberculosis-associated immune reconstitution 
      inflammatory syndrome among HIV/Tuberculosis co-infected patients in Southern 
      India.
PG  - 279-281
LID - 10.4103/ijmm.IJMM_16_163 [doi]
AB  - Immune reconstitution inflammatory syndrome (IRIS) continues to be a complication 
      in HIV/tuberculosis (TB) co-infected patients initiating highly active 
      antiretroviral therapy (HAART). The aim of this study was to evaluate the risk 
      factors associated with developing IRIS to identify a possible biomarker to 
      predict or diagnose IRIS in patients initiating HAART. A total of 175 HIV/TB 
      co-infected patients initiating HAART were followed up longitudinally during 
      September 2010 to May 2013 attending a HIV care clinic in Chennai. Patients were 
      followed up longitudinally after HAART initiation and baseline demographic, 
      laboratory parameters and treatment characteristics between patients with IRIS 
      events and those without IRIS events were compared. Chi-square or Fisher's exact 
      test for categorical variables and a Wilcoxon rank-sum test for continuous 
      variables were performed using SPSS, version 12.0 software. Patients with IRIS 
      had a significantly lower median baseline CD4+ T-cell count (P = 0.0039). There 
      were no differences in terms of sex, CD4 T-cell %, plasma viral load, time 
      interval between initiating ATT and HAART between the IRIS and non-IRIS patients. 
      Low CD4+ T-cell count (<100 cells/muL) could be used as a marker to screen and 
      monitor patients initiating HAART.
FAU - Vignesh, Ramachandran
AU  - Vignesh R
AD  - Infectious Diseases Laboratory, Y. R. Gaitonde Centre for AIDS Research and 
      Education, Chennai, Tamil Nadu, India; Laboratory-based Department, Universiti 
      Kuala Lumpur Royal College of Medicine Perak, Ipoh, Malaysia.
FAU - Swathirajan, Chinnambedu R
AU  - Swathirajan CR
AD  - Infectious Diseases Laboratory, Y. R. Gaitonde Centre for AIDS Research and 
      Education, Chennai, Tamil Nadu, India.
FAU - Solomon, Sunil S
AU  - Solomon SS
AD  - Medical Centre, Y. R. Gaitonde Centre for AIDS Research and Education, Chennai, 
      Tamil Nadu, India; Department of Infectious Diseases, Johns Hopkins School of 
      Medicine, Baltimore, USA.
FAU - Shankar, Esaki Muthu
AU  - Shankar EM
AD  - Infectious Diseases Laboratory, Y. R. Gaitonde Centre for AIDS Research and 
      Education, Chennai, Tamil Nadu, India.
FAU - Murugavel, Kailapuri G
AU  - Murugavel KG
AD  - Infectious Diseases Laboratory, Y. R. Gaitonde Centre for AIDS Research and 
      Education, Chennai, Tamil Nadu, India.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Indian J Med Microbiol
JT  - Indian journal of medical microbiology
JID - 8700903
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - Adult
MH  - Anti-Retroviral Agents/*administration & dosage/*adverse effects
MH  - CD4 Lymphocyte Count
MH  - Female
MH  - Follow-Up Studies
MH  - HIV Infections/*complications/*drug therapy
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*epidemiology
MH  - India/epidemiology
MH  - Male
MH  - Prospective Studies
MH  - Risk Factors
MH  - Sex Distribution
MH  - Tuberculosis/*complications
MH  - Viral Load
EDAT- 2017/07/07 06:00
MHDA- 2018/03/17 06:00
CRDT- 2017/07/07 06:00
PHST- 2017/07/07 06:00 [entrez]
PHST- 2017/07/07 06:00 [pubmed]
PHST- 2018/03/17 06:00 [medline]
AID - IndianJMedMicrobiol_2017_35_2_279_209570 [pii]
AID - 10.4103/ijmm.IJMM_16_163 [doi]
PST - ppublish
SO  - Indian J Med Microbiol. 2017 Apr-Jun;35(2):279-281. doi: 
      10.4103/ijmm.IJMM_16_163.