PMID- 28682918
OWN - NLM
STAT- MEDLINE
DCOM- 20170724
LR  - 20210109
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 27
DP  - 2017 Jul
TI  - A randomized controlled trial of acupressure as an adjunctive therapy to sodium 
      valproate on the prevention of chronic migraine with aura.
PG  - e7477
LID - 10.1097/MD.0000000000007477 [doi]
LID - e7477
AB  - BACKGROUND: The primary objective of the present study was to evaluate the 
      efficacy and safety of using acupressure as an adjunctive therapy to sodium 
      valproate (SV) combined with acupressure (ASV) on the prevention of chronic 
      migraine with aura (CMA). METHODS: A total of 98 patients with CMA were randomly 
      divided into an intervention group and a control group, with 49 patients in each 
      group. The patients in the intervention group received ASV, while the 
      participants in the control group received SV alone. The primary outcome was 
      measured by the numeric rating scale (NRS). The secondary outcomes including 
      frequency of migraine attacks, the times of using analgesics, and quality of 
      life, measured by the short-form 36 Health Survey Scale (SF-36) score. In 
      addition, adverse events (AEs) were also recorded throughout the trial. The 
      outcomes were measured at the end of the 8-week treatment, and 4-week follow-up. 
      RESULTS: After the 8-week treatment and 4-week follow-up, ASV efficacy was not 
      greater than that of SV alone regarding pain relief, as measured using the NRS, 
      and frequency of migraine attacks, consumption of analgesics, and quality of 
      life, as measured using the SF-36. However, ASV can significantly reduce the 
      nausea when compared with SV (P = .04). CONCLUSION: The present results indicate 
      that ASV can decrease migraine-related nausea during treatment, but cannot 
      relieve pain or enhance quality of life in patients with CMA.
FAU - Xu, Ji-Hua
AU  - Xu JH
AD  - Department of Neurology, Beijing ChaoYang Hospital, Capital Medical University, 
      Beijing, China.
FAU - Mi, He-Yin
AU  - Mi HY
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Analgesics)
RN  - 0 (Central Nervous System Agents)
RN  - 614OI1Z5WI (Valproic Acid)
SB  - IM
MH  - *Acupressure
MH  - Adult
MH  - Analgesics/therapeutic use
MH  - Central Nervous System Agents/*therapeutic use
MH  - Combined Modality Therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Migraine with Aura/*therapy
MH  - Pain Measurement
MH  - Quality of Life
MH  - Treatment Outcome
MH  - Valproic Acid/*therapeutic use
PMC - PMC5502191
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2017/07/07 06:00
MHDA- 2017/07/25 06:00
PMCR- 2017/07/07
CRDT- 2017/07/07 06:00
PHST- 2017/07/07 06:00 [entrez]
PHST- 2017/07/07 06:00 [pubmed]
PHST- 2017/07/25 06:00 [medline]
PHST- 2017/07/07 00:00 [pmc-release]
AID - 00005792-201707070-00060 [pii]
AID - MD-D-17-02933 [pii]
AID - 10.1097/MD.0000000000007477 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jul;96(27):e7477. doi: 10.1097/MD.0000000000007477.