PMID- 28683292
OWN - NLM
STAT- MEDLINE
DCOM- 20180402
LR  - 20181113
IS  - 1932-7420 (Electronic)
IS  - 1550-4131 (Print)
IS  - 1550-4131 (Linking)
VI  - 26
IP  - 1
DP  - 2017 Jul 5
TI  - Mice under Caloric Restriction Self-Impose a Temporal Restriction of Food Intake 
      as Revealed by an Automated Feeder System.
PG  - 267-277.e2
LID - S1550-4131(17)30349-2 [pii]
LID - 10.1016/j.cmet.2017.06.007 [doi]
AB  - Caloric restriction (CR) extends lifespan in mammals, yet the mechanisms 
      underlying its beneficial effects remain unknown. The manner in which CR has been 
      implemented in longevity experiments is variable, with both timing and frequency 
      of meals constrained by work schedules. It is commonplace to find that nocturnal 
      rodents are fed during the daytime and meals are spaced out, introducing 
      prolonged fasting intervals. Since implementation of feeding paradigms over the 
      lifetime is logistically difficult, automation is critical, but existing systems 
      are expensive and not amenable to scale. We have developed a system that controls 
      duration, amount, and timing of food availability and records feeding and 
      voluntary wheel-running activity in mice. Using this system, mice were exposed to 
      temporal or caloric restriction protocols. Mice under CR self-imposed a temporal 
      component by consolidating food intake and unexpectedly increasing wheel-running 
      activity during the rest phase, revealing previously unrecognized relationships 
      among feeding, metabolism, and behavior.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Acosta-Rodriguez, Victoria A
AU  - Acosta-Rodriguez VA
AD  - Department of Neuroscience, University of Texas Southwestern Medical Center, 
      Dallas, TX 75390-9111, USA.
FAU - de Groot, Marleen H M
AU  - de Groot MHM
AD  - Department of Neuroscience, University of Texas Southwestern Medical Center, 
      Dallas, TX 75390-9111, USA; Howard Hughes Medical Institute, University of Texas 
      Southwestern Medical Center, Dallas, TX 75390-9111, USA.
FAU - Rijo-Ferreira, Filipa
AU  - Rijo-Ferreira F
AD  - Department of Neuroscience, University of Texas Southwestern Medical Center, 
      Dallas, TX 75390-9111, USA; Howard Hughes Medical Institute, University of Texas 
      Southwestern Medical Center, Dallas, TX 75390-9111, USA.
FAU - Green, Carla B
AU  - Green CB
AD  - Department of Neuroscience, University of Texas Southwestern Medical Center, 
      Dallas, TX 75390-9111, USA. Electronic address: carla.green@utsouthwestern.edu.
FAU - Takahashi, Joseph S
AU  - Takahashi JS
AD  - Department of Neuroscience, University of Texas Southwestern Medical Center, 
      Dallas, TX 75390-9111, USA; Howard Hughes Medical Institute, University of Texas 
      Southwestern Medical Center, Dallas, TX 75390-9111, USA. Electronic address: 
      joseph.takahashi@utsouthwestern.edu.
LA  - eng
GR  - R01 AG045795/AG/NIA NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Cell Metab
JT  - Cell metabolism
JID - 101233170
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Animals
MH  - *Appetite Regulation
MH  - Blood Glucose/metabolism
MH  - *Caloric Restriction
MH  - Eating
MH  - Feeding Behavior
MH  - Homeostasis
MH  - Locomotion
MH  - Longevity
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Weight Loss
PMC - PMC5576447
MID - NIHMS885797
OTO - NOTNLM
OT  - alternate day feeding
OT  - automated feeder system
OT  - body weight
OT  - caloric restriction
OT  - circadian rhythm
OT  - feeding pattern
OT  - intermittent fasting
OT  - mouse
OT  - temporal restriction
OT  - wheel-running activity
EDAT- 2017/07/07 06:00
MHDA- 2018/04/03 06:00
PMCR- 2018/07/05
CRDT- 2017/07/07 06:00
PHST- 2017/02/20 00:00 [received]
PHST- 2017/05/08 00:00 [revised]
PHST- 2017/06/13 00:00 [accepted]
PHST- 2017/07/07 06:00 [entrez]
PHST- 2017/07/07 06:00 [pubmed]
PHST- 2018/04/03 06:00 [medline]
PHST- 2018/07/05 00:00 [pmc-release]
AID - S1550-4131(17)30349-2 [pii]
AID - 10.1016/j.cmet.2017.06.007 [doi]
PST - ppublish
SO  - Cell Metab. 2017 Jul 5;26(1):267-277.e2. doi: 10.1016/j.cmet.2017.06.007.