PMID- 28683723
OWN - NLM
STAT- MEDLINE
DCOM- 20171107
LR  - 20181202
IS  - 1471-2253 (Electronic)
IS  - 1471-2253 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Jul 6
TI  - Case report: anaesthetic management of radical gastrectomy for gastric cancer 
      associated with anti-N-methyl-D-aspartate receptor encephalitis.
PG  - 90
LID - 10.1186/s12871-017-0379-2 [doi]
LID - 90
AB  - BACKGROUND: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a rare 
      neurological disorder that is caused by the production of antibodies against 
      NMDARs. As many anaesthetic drugs interact with NMDARs and may worsen the disease 
      and because the disease poses risks, such as cardiovascular events, hyperthermia 
      and respiratory insufficiency, while under anaesthesia, administering anaesthesia 
      to patients with this disorder is clinically challenging. CASE PRESENTATION: A 
      55-year-old man with gastric cancer associated with anti-NMDAR encephalitis who 
      was diagnosed 8 months prior was admitted to Peking University Cancer Hospital 
      for tumour resection. Before surgery, the patient's symptoms had been 
      successfully controlled via aggressive immunotherapy. Radical gastrectomy was 
      performed under general anaesthesia induced with remifentanil, propofol, and 
      cisatracurium and maintained with sevoflurane and remifentanil. The patient had a 
      favourable recovery without any adverse symptoms or post-operative complications. 
      CONCLUSIONS: Adequate preparation for surgery is essential for the anaesthetic 
      management of patients with anti-NMDAR encephalitis. These rare patients may 
      benefit from general anaesthesia induced using remifentanil, propofol and 
      cisatracurium and maintained using sevoflurane and remifentanil. Additionally, 
      the use of NMDA antagonists, such as ketamine, nitrous oxide and tramadol, should 
      be avoided.
FAU - Ding, Lei
AU  - Ding L
AD  - Key laboratory of Carcinogenesis and Translational Research (Ministry of 
      Education/Beijing), Department of Anaesthesiology, Peking University Cancer 
      Hospital & Institute, Beijing, 100142, China.
FAU - Tan, Hongyu
AU  - Tan H
AUID- ORCID: 0000-0002-0228-4241
AD  - Key laboratory of Carcinogenesis and Translational Research (Ministry of 
      Education/Beijing), Department of Anaesthesiology, Peking University Cancer 
      Hospital & Institute, Beijing, 100142, China. hongyutan0062@sina.com.
FAU - Li, Ziyu
AU  - Li Z
AD  - Key laboratory of Carcinogenesis and Translational Research (Ministry of 
      Education/Beijing), Department of Gastrointestinal Surgery, Peking University 
      Cancer Hospital & Institute, Beijing, 100142, China.
FAU - Ji, Jiafu
AU  - Ji J
AD  - Key laboratory of Carcinogenesis and Translational Research (Ministry of 
      Education/Beijing), Department of Gastrointestinal Surgery, Peking University 
      Cancer Hospital & Institute, Beijing, 100142, China.
FAU - Song, Xuejun
AU  - Song X
AD  - Key laboratory of Carcinogenesis and Translational Research (Ministry of 
      Education/Beijing), Department of Anaesthesiology, Peking University Cancer 
      Hospital & Institute, Beijing, 100142, China.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170706
PL  - England
TA  - BMC Anesthesiol
JT  - BMC anesthesiology
JID - 100968535
RN  - 0 (Anesthetics, General)
RN  - 0 (Methyl Ethers)
RN  - 0 (Neuromuscular Blocking Agents)
RN  - 0 (Piperidines)
RN  - 2GQ1IRY63P (Atracurium)
RN  - 38LVP0K73A (Sevoflurane)
RN  - P10582JYYK (Remifentanil)
RN  - QX62KLI41N (cisatracurium)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Anesthetics, General/administration & dosage
MH  - Anti-N-Methyl-D-Aspartate Receptor Encephalitis/*complications
MH  - Atracurium/administration & dosage/analogs & derivatives
MH  - Drug Therapy, Combination
MH  - *Gastrectomy
MH  - Humans
MH  - Male
MH  - Methyl Ethers/administration & dosage
MH  - Middle Aged
MH  - Neuromuscular Blocking Agents/administration & dosage
MH  - Piperidines/administration & dosage
MH  - Propofol/administration & dosage
MH  - Remifentanil
MH  - Sevoflurane
MH  - Stomach Neoplasms/*surgery
PMC - PMC5500999
OTO - NOTNLM
OT  - Anaesthetic management
OT  - Anti-N-methyl-D-aspartate receptor encephalitis
OT  - Case report
OT  - Gastric cancer
EDAT- 2017/07/08 06:00
MHDA- 2017/11/08 06:00
PMCR- 2017/07/06
CRDT- 2017/07/08 06:00
PHST- 2016/12/23 00:00 [received]
PHST- 2017/06/14 00:00 [accepted]
PHST- 2017/07/08 06:00 [entrez]
PHST- 2017/07/08 06:00 [pubmed]
PHST- 2017/11/08 06:00 [medline]
PHST- 2017/07/06 00:00 [pmc-release]
AID - 10.1186/s12871-017-0379-2 [pii]
AID - 379 [pii]
AID - 10.1186/s12871-017-0379-2 [doi]
PST - epublish
SO  - BMC Anesthesiol. 2017 Jul 6;17(1):90. doi: 10.1186/s12871-017-0379-2.