PMID- 28684794
OWN - NLM
STAT- MEDLINE
DCOM- 20190109
LR  - 20190109
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Jul 6
TI  - Altered Spontaneous Brain Activity in Children with Early Tourette Syndrome: a 
      Resting-state fMRI Study.
PG  - 4808
LID - 10.1038/s41598-017-04148-z [doi]
LID - 4808
AB  - Tourette syndrome (TS) is a childhood-onset chronic disorder characterized by the 
      presence of multiple motor and vocal tics. This study investigated the 
      alterations of spontaneous brain activities in children with TS by resting-state 
      functional magnetic resonance imaging (rs-fMRI). We obtained rs-fMRI scans from 
      21 drug-naive and pure TS children and 29 demographically matched healthy 
      children. The amplitude of low-frequency fluctuation (ALFF), fractional ALFF 
      (fALFF) and regional homogeneity (ReHo) of rs-fMRI data were calculated to 
      measure spontaneous brain activity. We found significant alterations of ALFF or 
      fALFF in vision-related structures including the calcarine sulcus, the cuneus, 
      the fusiform gyrus, and the left insula in TS children. Decreased ReHo was found 
      in the right cerebellum. Further analysis showed that the ReHo value of the right 
      cerebellum was positively correlated with TS duration. Our study provides 
      empirical evidence for abnormal spontaneous neuronal activity in TS patients, 
      which may implicate the neurophysiological mechanism in TS children. Moreover, 
      the right cerebellum can be potentially used as a biomarker for the 
      pathophysiology of early TS in children.
FAU - Liu, Yue
AU  - Liu Y
AD  - Department of Radiology, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing, China.
FAU - Wang, Jieqiong
AU  - Wang J
AD  - State Key Laboratory of Management and Control for Complex Systems, Institute of 
      Automation, Chinese Academy of Sciences, Beijing, China.
AD  - University of Chinese Academy of Sciences, Beijing, China.
FAU - Zhang, Jishui
AU  - Zhang J
AD  - Department of Neurology, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing, China.
FAU - Wen, Hongwei
AU  - Wen H
AD  - State Key Laboratory of Management and Control for Complex Systems, Institute of 
      Automation, Chinese Academy of Sciences, Beijing, China.
AD  - University of Chinese Academy of Sciences, Beijing, China.
FAU - Zhang, Yue
AU  - Zhang Y
AD  - Department of Radiology, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing, China.
FAU - Kang, Huiying
AU  - Kang H
AD  - Department of Radiology, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing, China.
FAU - Wang, Xu
AU  - Wang X
AD  - Department of Neurology, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing, China.
FAU - Li, Wenfeng
AU  - Li W
AD  - Department of Radiology, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing, China.
FAU - He, Huiguang
AU  - He H
AUID- ORCID: 0000-0002-0684-1711
AD  - State Key Laboratory of Management and Control for Complex Systems, Institute of 
      Automation, Chinese Academy of Sciences, Beijing, China. huiguang.he@ia.ac.cn.
AD  - University of Chinese Academy of Sciences, Beijing, China. huiguang.he@ia.ac.cn.
AD  - Center for Excellence in Brain Science and Intelligence Technology, Chinese 
      Academy of Sciences, Beijing, China. huiguang.he@ia.ac.cn.
FAU - Peng, Yun
AU  - Peng Y
AD  - Department of Radiology, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing, China. ppengyun@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170706
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Age of Onset
MH  - Brain Mapping
MH  - Case-Control Studies
MH  - Cerebellum/diagnostic imaging/pathology/*physiopathology
MH  - Cerebral Cortex/diagnostic imaging/pathology/*physiopathology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Occipital Lobe/diagnostic imaging/pathology/*physiopathology
MH  - Rest/physiology
MH  - Temporal Lobe/diagnostic imaging/pathology/*physiopathology
MH  - Tourette Syndrome/diagnostic imaging/pathology/*physiopathology
PMC - PMC5500479
COIS- The authors declare that they have no competing interests.
EDAT- 2017/07/08 06:00
MHDA- 2019/01/10 06:00
PMCR- 2017/07/06
CRDT- 2017/07/08 06:00
PHST- 2016/07/11 00:00 [received]
PHST- 2017/05/16 00:00 [accepted]
PHST- 2017/07/08 06:00 [entrez]
PHST- 2017/07/08 06:00 [pubmed]
PHST- 2019/01/10 06:00 [medline]
PHST- 2017/07/06 00:00 [pmc-release]
AID - 10.1038/s41598-017-04148-z [pii]
AID - 4148 [pii]
AID - 10.1038/s41598-017-04148-z [doi]
PST - epublish
SO  - Sci Rep. 2017 Jul 6;7(1):4808. doi: 10.1038/s41598-017-04148-z.