PMID- 28685618
OWN - NLM
STAT- MEDLINE
DCOM- 20190805
LR  - 20191008
IS  - 1559-7016 (Electronic)
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 38
IP  - 8
DP  - 2018 Aug
TI  - Minocycline plus N-acteylcysteine induces remyelination, synergistically protects 
      oligodendrocytes and modifies neuroinflammation in a rat model of mild traumatic 
      brain injury.
PG  - 1312-1326
LID - 10.1177/0271678X17718106 [doi]
AB  - Mild traumatic brain injury afflicts over 2 million people annually and little 
      can be done for the underlying injury. The Food and Drug Administration-approved 
      drugs Minocycline plus N-acetylcysteine (MINO plus NAC) synergistically improved 
      cognition and memory in a rat mild controlled cortical impact (mCCI) model of 
      traumatic brain injury.(3) The underlying cellular and molecular mechanisms of 
      the drug combination are unknown. This study addressed the effect of the drug 
      combination on white matter damage and neuroinflammation after mCCI. Brain tissue 
      from mCCI rats given either sham-injury, saline, MINO alone, NAC alone, or MINO 
      plus NAC was investigated via histology and qPCR at four time points (2, 4, 7, 
      and 14 days post-injury) for markers of white matter damage and 
      neuroinflammation. MINO plus NAC synergistically protected resident 
      oligodendrocytes and decreased the number of oligodendrocyte precursor cells. 
      Activation of microglia/macrophages (MP/MG) was synergistically increased in 
      white matter two days post-injury after MINO plus NAC treatment. Patterns of M1 
      and M2 MP/MG were also altered after treatment. The modulation of 
      neuroinflammation is a potential mechanism to promote remyelination and improve 
      cognition and memory. These data also provide new and important insights into how 
      drug treatments can induce repair after traumatic brain injury.
FAU - Haber, Margalit
AU  - Haber M
AD  - Department of Physiology and Pharmacology, Robert F. Furchgott Center for Neural 
      and Behavioral Science, SUNY-Downstate Medical Center, NY, USA.
FAU - James, Jessica
AU  - James J
AD  - Department of Physiology and Pharmacology, Robert F. Furchgott Center for Neural 
      and Behavioral Science, SUNY-Downstate Medical Center, NY, USA.
FAU - Kim, Justine
AU  - Kim J
AD  - Department of Physiology and Pharmacology, Robert F. Furchgott Center for Neural 
      and Behavioral Science, SUNY-Downstate Medical Center, NY, USA.
FAU - Sangobowale, Michael
AU  - Sangobowale M
AD  - Department of Physiology and Pharmacology, Robert F. Furchgott Center for Neural 
      and Behavioral Science, SUNY-Downstate Medical Center, NY, USA.
FAU - Irizarry, Rachel
AU  - Irizarry R
AD  - Department of Physiology and Pharmacology, Robert F. Furchgott Center for Neural 
      and Behavioral Science, SUNY-Downstate Medical Center, NY, USA.
FAU - Ho, Johnson
AU  - Ho J
AD  - Department of Physiology and Pharmacology, Robert F. Furchgott Center for Neural 
      and Behavioral Science, SUNY-Downstate Medical Center, NY, USA.
FAU - Nikulina, Elena
AU  - Nikulina E
AD  - Department of Physiology and Pharmacology, Robert F. Furchgott Center for Neural 
      and Behavioral Science, SUNY-Downstate Medical Center, NY, USA.
FAU - Grin'kina, Natalia M
AU  - Grin'kina NM
AD  - Department of Physiology and Pharmacology, Robert F. Furchgott Center for Neural 
      and Behavioral Science, SUNY-Downstate Medical Center, NY, USA.
FAU - Ramadani, Albana
AU  - Ramadani A
AD  - Department of Physiology and Pharmacology, Robert F. Furchgott Center for Neural 
      and Behavioral Science, SUNY-Downstate Medical Center, NY, USA.
FAU - Hartman, Isabella
AU  - Hartman I
AD  - Department of Physiology and Pharmacology, Robert F. Furchgott Center for Neural 
      and Behavioral Science, SUNY-Downstate Medical Center, NY, USA.
FAU - Bergold, Peter J
AU  - Bergold PJ
AD  - Department of Physiology and Pharmacology, Robert F. Furchgott Center for Neural 
      and Behavioral Science, SUNY-Downstate Medical Center, NY, USA.
LA  - eng
GR  - R01 NS076693/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20170707
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - FYY3R43WGO (Minocycline)
RN  - WYQ7N0BPYC (Acetylcysteine)
MH  - Acetylcysteine/*therapeutic use
MH  - Animals
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Antioxidants/*therapeutic use
MH  - Brain Injuries, Traumatic/complications/*drug therapy/pathology
MH  - Disease Models, Animal
MH  - Drug Synergism
MH  - Inflammation/complications/drug therapy/pathology
MH  - Male
MH  - Minocycline/*therapeutic use
MH  - Oligodendroglia/*drug effects/pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Remyelination/*drug effects
PMC - PMC6092769
OTO - NOTNLM
OT  - Brain trauma
OT  - immunohistochemistry
OT  - inflammation
OT  - microglia
OT  - oligodendrocytes
OT  - white matter
EDAT- 2017/07/08 06:00
MHDA- 2019/08/06 06:00
PMCR- 2019/08/01
CRDT- 2017/07/08 06:00
PHST- 2017/07/08 06:00 [pubmed]
PHST- 2019/08/06 06:00 [medline]
PHST- 2017/07/08 06:00 [entrez]
PHST- 2019/08/01 00:00 [pmc-release]
AID - 10.1177_0271678X17718106 [pii]
AID - 10.1177/0271678X17718106 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 2018 Aug;38(8):1312-1326. doi: 
      10.1177/0271678X17718106. Epub 2017 Jul 7.