PMID- 28686282
OWN - NLM
STAT- MEDLINE
DCOM- 20170830
LR  - 20170830
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 8
IP  - 7
DP  - 2017 Jul 19
TI  - Early maternal separation induces preference for sucrose and aspartame associated 
      with increased blood glucose and hyperactivity.
PG  - 2592-2600
LID - 10.1039/c7fo00408g [doi]
AB  - Early life stress and exposure to sweeteners lead to physiological and behavioral 
      alterations in adulthood. Nevertheless, many genetic and environmental factors as 
      well as the neurobiological mechanisms that contribute to the development of 
      these disorders are not fully understood. Similarly, evidence about the long-term 
      metabolic effects of exposure to sweeteners in early life is limited and 
      inconsistent. This study used an animal model of maternal separation during 
      breastfeeding (MS) to analyze the effects of early life stress on consumption of 
      sweeteners, weight gain, blood glucose and locomotion. Rats were housed under a 
      reversed light/dark cycle (lights off at 7:00 h) with ad libitum access to water 
      and food. In the MS protocol, MS pups were separated from the dam for 6 h per day 
      in two periods of 180 minutes (7:00-10:00 and 13:00-16:00 h) during the dark 
      phase of postnatal day (PND) 1 to PND 21. Non-separated (NS) pups served as 
      controls. On PND 22 rats were grouped by sex and treatment. From PND 26 to PND 50 
      sucrose and aspartame were provided to rats, and sweetener intake, body weight 
      and blood glucose-related measures were scored. On PND 50, both male and female 
      rats were exposed to the open field test to obtain locomotion and anxiety-related 
      measures. Results showed that both early maternal separation and sweetener intake 
      during adolescence resulted in increased blood glucose and hyperactivity in male 
      rats but not in female rats. Data suggest that the combination of early stress 
      and exposure to sucrose and aspartame could be a risk factor for the development 
      of chronic diseases such as diabetes, as well as for behavioral alterations.
FAU - Aya-Ramos, L
AU  - Aya-Ramos L
AD  - Universidad Nacional de Colombia, Bogota, Facultad de Medicina, Departamento de 
      Ciencias fisiologicas, Grupo neurobiologia y comportamiento, Bogota, D.C. 11001, 
      Colombia. zjduenasg@unal.edu.co.
FAU - Contreras-Vargas, C
AU  - Contreras-Vargas C
FAU - Rico, J L
AU  - Rico JL
FAU - Duenas, Z
AU  - Duenas Z
LA  - eng
PT  - Journal Article
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Blood Glucose)
RN  - 57-50-1 (Sucrose)
RN  - Z0H242BBR1 (Aspartame)
SB  - IM
MH  - Animals
MH  - Anxiety/metabolism/physiopathology/*psychology
MH  - Aspartame/*metabolism
MH  - Blood Glucose/*metabolism
MH  - Body Weight
MH  - Disease Models, Animal
MH  - Female
MH  - *Food Preferences
MH  - Humans
MH  - Male
MH  - *Maternal Deprivation
MH  - Rats
MH  - Rats, Wistar
MH  - Sucrose/*metabolism
EDAT- 2017/07/08 06:00
MHDA- 2017/08/31 06:00
CRDT- 2017/07/08 06:00
PHST- 2017/07/08 06:00 [pubmed]
PHST- 2017/08/31 06:00 [medline]
PHST- 2017/07/08 06:00 [entrez]
AID - 10.1039/c7fo00408g [doi]
PST - ppublish
SO  - Food Funct. 2017 Jul 19;8(7):2592-2600. doi: 10.1039/c7fo00408g.