PMID- 28686554
OWN - NLM
STAT- MEDLINE
DCOM- 20171026
LR  - 20181113
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 125
IP  - 6
DP  - 2017 Jun 26
TI  - Geographic Differences in Persistent Organic Pollutant Levels of Yellowfin Tuna.
PG  - 067014
LID - 10.1289/EHP518 [doi]
LID - 067014
AB  - BACKGROUND: Fish are a source of persistent organic pollutants (POPs) in the 
      human diet. Although species, trophic level, and means of production are 
      typically considered in predicting fish pollutant load, and thus recommendations 
      of consumption, capture location is usually not accounted for. OBJECTIVES: 
      Yellowfin tuna (Thunnus albacares) are harvested from across the world's oceans 
      and are widely consumed. Here, we determined geographic variation in the overall 
      mass, concentration, and composition of POPs in yellowfin and examined the 
      differences in levels of several POP congeners of potential relevance to human 
      health. METHODS: We sampled dorsal muscle of 117 yellowfin tuna from 12 locations 
      worldwide, and measured POP levels using combined liquid or gas chromatography 
      and mass spectrometry according to U.S. Environmental Protection Agency standard 
      procedures. RESULTS: POP levels varied significantly among sites, more than 
      36-fold on a mass basis. Individual fish levels ranged from 0.16 to 138.29 ng/g 
      wet weight and lipid-normalized concentrations from 0.1 to 12.7 muM. Levels of 10 
      congeners that interfere with the cellular defense protein P-glycoprotein, termed 
      transporter interfering compounds (TICs), ranged from 0.05 to 35.03 ng/g wet 
      weight and from 0.03 to 3.32 muM in tuna lipid. Levels of TICs, and their 
      individual congeners, were strongly associated with the overall POP load. 
      Risk-based analysis of several carcinogenic POPs indicated that the fish with the 
      highest levels of these potentially harmful compounds were clustered at specific 
      geographic locations. CONCLUSIONS: Capture location is an important consideration 
      when assessing the level and risk of human exposure to POPs through ingestion of 
      wild fish. https://doi.org/10.1289/EHP518.
FAU - Nicklisch, Sascha C T
AU  - Nicklisch SCT
AD  - Marine Biology Research Division, Scripps Institution of Oceanography, University 
      of California, San Diego , La Jolla, California, USA.
FAU - Bonito, Lindsay T
AU  - Bonito LT
AD  - Marine Biology Research Division, Scripps Institution of Oceanography, University 
      of California, San Diego , La Jolla, California, USA.
FAU - Sandin, Stuart
AU  - Sandin S
AD  - Marine Biology Research Division, Scripps Institution of Oceanography, University 
      of California, San Diego , La Jolla, California, USA.
FAU - Hamdoun, Amro
AU  - Hamdoun A
AD  - Marine Biology Research Division, Scripps Institution of Oceanography, University 
      of California, San Diego , La Jolla, California, USA.
LA  - eng
GR  - R01 ES021985/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20170626
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
CIN - Environ Health Perspect. 2017 Jul 25;125(7):074003. PMID: 28749777
MH  - Animals
MH  - *Environmental Monitoring
MH  - Tuna/*metabolism
MH  - Water Pollutants, Chemical/analysis/*metabolism
MH  - Water Pollution, Chemical/*statistics & numerical data
PMC - PMC5714290
EDAT- 2017/07/08 06:00
MHDA- 2017/10/27 06:00
PMCR- 2017/06/26
CRDT- 2017/07/08 06:00
PHST- 2016/05/16 00:00 [received]
PHST- 2016/09/13 00:00 [revised]
PHST- 2016/09/20 00:00 [accepted]
PHST- 2017/07/08 06:00 [entrez]
PHST- 2017/07/08 06:00 [pubmed]
PHST- 2017/10/27 06:00 [medline]
PHST- 2017/06/26 00:00 [pmc-release]
AID - EHP518 [pii]
AID - 10.1289/EHP518 [doi]
PST - epublish
SO  - Environ Health Perspect. 2017 Jun 26;125(6):067014. doi: 10.1289/EHP518.