PMID- 28687557
OWN - NLM
STAT- MEDLINE
DCOM- 20180108
LR  - 20220408
IS  - 1532-2548 (Electronic)
IS  - 0032-0889 (Print)
IS  - 0032-0889 (Linking)
VI  - 174
IP  - 4
DP  - 2017 Aug
TI  - A PIF1/PIF3-HY5-BBX23 Transcription Factor Cascade Affects Photomorphogenesis.
PG  - 2487-2500
LID - 10.1104/pp.17.00418 [doi]
AB  - Light signaling plays an essential role in controlling higher plants' early 
      developmental process termed as photomorphogenesis. Transcriptional regulation is 
      a vital mechanism that is orchestrated by transcription factors and other 
      regulatory proteins working in concert to finely tune gene expression. Although 
      many transcription factors/regulators have been characterized in the 
      light-signaling pathway, their interregulation remains largely unknown. Here, we 
      show that PHYTOCHROME-INTERACTING FACTOR3 (PIF3) and PIF1 transcription factors 
      directly bind to the regulatory regions of ELONGATED HYPOCOTYL5 (HY5) and a B-box 
      gene BBX23 and activate their expression in Arabidopsis (Arabidopsis thaliana). 
      We found that BBX23 and its close homolog gene BBX22 play a redundant role in 
      regulating hypocotyl growth, and that plants overexpressing BBX23 display reduced 
      hypocotyl elongation under red, far-red, and blue light conditions. Intriguingly, 
      BBX23 transcription is inhibited by light, whereas its protein is degraded in 
      darkness. Furthermore, we demonstrate that HY5 physically interacts with BBX23, 
      and these two proteins coordinately regulate the expression of both light-induced 
      and light-repressed genes. BBX23 is also recruited to the promoter sequences of 
      the light-responsive genes in a partial HY5-dependent manner. Taken together, our 
      study reveals that the transcriptional cascade consisting of PIF1/PIF3, HY5, and 
      BBX23 controls photomorphogenesis, providing a transcriptional regulatory layer 
      by which plants fine-tune their growth in response to changing light environment.
CI  - (c) 2017 American Society of Plant Biologists. All Rights Reserved.
FAU - Zhang, Xinyu
AU  - Zhang X
AD  - Key Laboratory of Photobiology, CAS Center for Excellence in Molecular Plant 
      Sciences, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, 
      China.
AD  - University of Chinese Academy of Sciences, Beijing 100049, China.
FAU - Huai, Junling
AU  - Huai J
AD  - Key Laboratory of Photobiology, CAS Center for Excellence in Molecular Plant 
      Sciences, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, 
      China.
FAU - Shang, Fangfang
AU  - Shang F
AD  - Key Laboratory of Photobiology, CAS Center for Excellence in Molecular Plant 
      Sciences, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, 
      China.
AD  - University of Chinese Academy of Sciences, Beijing 100049, China.
FAU - Xu, Gang
AU  - Xu G
AD  - Key Laboratory of Photobiology, CAS Center for Excellence in Molecular Plant 
      Sciences, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, 
      China.
AD  - University of Chinese Academy of Sciences, Beijing 100049, China.
FAU - Tang, Weijiang
AU  - Tang W
AD  - Key Laboratory of Photobiology, CAS Center for Excellence in Molecular Plant 
      Sciences, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, 
      China.
FAU - Jing, Yanjun
AU  - Jing Y
AUID- ORCID: 0000-0002-4772-7923
AD  - Key Laboratory of Photobiology, CAS Center for Excellence in Molecular Plant 
      Sciences, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, 
      China.
FAU - Lin, Rongcheng
AU  - Lin R
AUID- ORCID: 0000-0001-8346-3390
AD  - Key Laboratory of Photobiology, CAS Center for Excellence in Molecular Plant 
      Sciences, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China 
      rclin@ibcas.ac.cn.
AD  - University of Chinese Academy of Sciences, Beijing 100049, China.
LA  - eng
PT  - Journal Article
DEP - 20170707
PL  - United States
TA  - Plant Physiol
JT  - Plant physiology
JID - 0401224
RN  - 0 (Arabidopsis Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Arabidopsis/genetics/*metabolism/*radiation effects
MH  - Arabidopsis Proteins/genetics/*metabolism
MH  - Gene Expression Regulation, Plant/radiation effects
MH  - Genes, Plant
MH  - *Light
MH  - Models, Biological
MH  - Morphogenesis/genetics/*radiation effects
MH  - Promoter Regions, Genetic
MH  - Protein Binding/radiation effects
MH  - RNA, Messenger/genetics/metabolism
MH  - Transcription Factors/*metabolism
MH  - Transcription, Genetic/radiation effects
PMC - PMC5543951
EDAT- 2017/07/09 06:00
MHDA- 2018/01/09 06:00
PMCR- 2017/07/07
CRDT- 2017/07/09 06:00
PHST- 2017/03/31 00:00 [received]
PHST- 2017/07/01 00:00 [accepted]
PHST- 2017/07/09 06:00 [pubmed]
PHST- 2018/01/09 06:00 [medline]
PHST- 2017/07/09 06:00 [entrez]
PHST- 2017/07/07 00:00 [pmc-release]
AID - pp.17.00418 [pii]
AID - PP2017RA00418DR2 [pii]
AID - 10.1104/pp.17.00418 [doi]
PST - ppublish
SO  - Plant Physiol. 2017 Aug;174(4):2487-2500. doi: 10.1104/pp.17.00418. Epub 2017 Jul 
      7.