PMID- 28689110
OWN - NLM
STAT- MEDLINE
DCOM- 20180213
LR  - 20240327
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Print)
IS  - 0160-4120 (Linking)
VI  - 107
DP  - 2017 Oct
TI  - Persistent organic pollutants in infants and toddlers: Relationship between 
      concentrations in matched plasma and faecal samples.
PG  - 82-88
LID - S0160-4120(17)30627-X [pii]
LID - 10.1016/j.envint.2017.06.019 [doi]
AB  - Early-childhood biomonitoring of persistent organic pollutants (POPs) is 
      challenging due to the logistic and ethical limitations associated with blood 
      sampling. We investigated using faeces as a non-invasive matrix to estimate 
      internal exposure to POPs. The concentrations of selected POPs were measured in 
      matched plasma and faecal samples collected from 20 infants/toddlers (aged 
      13+/-4.8months), including a repeat sample time point for 13 infants (~5months 
      apart). We observed higher rates of POP quantification in faeces (2g dry weight) 
      than in plasma (0.5mL). Among the five chemicals that had quantification 
      frequencies over 50% in both matrices, except for HCB, log concentration in 
      faeces (C(f)) and blood (C(b)) were correlated (r>0.74, P<0.05) for 
      p.p'-dichlorodiphenyldichloroethylene (p,p'-DDE), 2,3',4,4',5-pentachlorobiphenyl 
      (PCB118), 2,2',3,4,4',5'-pentachlorobiphenyl (PCB138) and 
      2,2',4,4',5,5'-pentachlorobiphenyl (PCB153). We determined faeces:plasma 
      concentration ratios (K(fb)), which can be used to estimate C(b) from 
      measurements of C(f) for infants/toddlers. For a given chemical, the variation in 
      K(fb) across individuals was considerable (CV from 0.46 to 0.70). Between 5% and 
      50% of this variation was attributed to short-term intra-individual variability 
      between successive faecal samples. This variability could be reduced by pooling 
      faeces samples over several days. Some of the remaining variability was 
      attributed to longer-term intra-individual variability, which was consistent with 
      previously reported observations of a decrease in K(fb) over the first year of 
      life. The strong correlations between C(f) and C(b) demonstrate the promise of 
      using faeces for biomonitoring of these compounds. Future research on the sources 
      of variability in K(fb) could improve the precision and utility of this 
      technique.
CI  - Copyright (c) 2017. Published by Elsevier Ltd.
FAU - Chen, Yiqin
AU  - Chen Y
AD  - Queensland Alliance for Environmental Health Sciences, The University of 
      Queensland, Australia. Electronic address: celerychenyiqin2017@outlook.com.
FAU - Sjodin, Andreas
AU  - Sjodin A
AD  - Centers for Disease Control and Prevention, Atlanta, GA, USA.
FAU - McLachlan, Michael S
AU  - McLachlan MS
AD  - Department of Environmental Science and Analytical Chemistry (ACES), Stockholm 
      University, Sweden.
FAU - English, Karin
AU  - English K
AD  - Children's Health and Environment Program, Child Health Research Centre, The 
      University of Queensland, Australia.
FAU - Aylward, Lesa L
AU  - Aylward LL
AD  - Queensland Alliance for Environmental Health Sciences, The University of 
      Queensland, Australia; Summit Toxicology, LLP, Falls Church, VA, USA.
FAU - Toms, Leisa-Maree L
AU  - Toms LL
AD  - School of Public Health and Social Work, Institute of Health and Biomedical 
      Innovation, Faculty of Health, Queensland University of Technology, Australia.
FAU - Varghese, Julie
AU  - Varghese J
AD  - Children's Health and Environment Program, Child Health Research Centre, The 
      University of Queensland, Australia.
FAU - Sly, Peter D
AU  - Sly PD
AD  - Children's Health and Environment Program, Child Health Research Centre, The 
      University of Queensland, Australia.
FAU - Mueller, Jochen F
AU  - Mueller JF
AD  - Queensland Alliance for Environmental Health Sciences, The University of 
      Queensland, Australia.
LA  - eng
GR  - CC999999/Intramural CDC HHS/United States
PT  - Clinical Trial, Phase II
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170706
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
SB  - IM
MH  - Child, Preschool
MH  - Double-Blind Method
MH  - Environmental Monitoring/methods
MH  - Environmental Pollutants/*analysis/*blood
MH  - Feces/*chemistry
MH  - Female
MH  - Halogenated Diphenyl Ethers/analysis/blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/analysis/blood
MH  - Infant
MH  - Male
PMC - PMC5633368
MID - NIHMS897951
OTO - NOTNLM
OT  - Blood
OT  - Faeces
OT  - Infants
OT  - Non-invasive bio-monitoring
OT  - POPs
OT  - Toddlers
EDAT- 2017/07/10 06:00
MHDA- 2018/02/14 06:00
PMCR- 2018/10/01
CRDT- 2017/07/10 06:00
PHST- 2017/04/05 00:00 [received]
PHST- 2017/06/22 00:00 [revised]
PHST- 2017/06/23 00:00 [accepted]
PHST- 2017/07/10 06:00 [pubmed]
PHST- 2018/02/14 06:00 [medline]
PHST- 2017/07/10 06:00 [entrez]
PHST- 2018/10/01 00:00 [pmc-release]
AID - S0160-4120(17)30627-X [pii]
AID - 10.1016/j.envint.2017.06.019 [doi]
PST - ppublish
SO  - Environ Int. 2017 Oct;107:82-88. doi: 10.1016/j.envint.2017.06.019. Epub 2017 Jul 
      6.