PMID- 28689258
OWN - NLM
STAT- MEDLINE
DCOM- 20171204
LR  - 20181113
IS  - 1432-1920 (Electronic)
IS  - 0028-3940 (Linking)
VI  - 59
IP  - 8
DP  - 2017 Aug
TI  - Differences in dynamic and static functional connectivity between young and 
      elderly healthy adults.
PG  - 781-789
LID - 10.1007/s00234-017-1875-2 [doi]
AB  - PURPOSE: Brain connectivity is highly dynamic, but functional connectivity (FC) 
      studies using resting-state functional magnetic resonance imaging (rs-fMRI) 
      assume it to be static. This study assessed differences in dynamic FC between 
      young healthy adults (YH) and elderly healthy adults (EH) compared to static FC. 
      METHODS: Using rs-fMRI data from 12 YH and 31 EH, FC was assessed in six 
      functional regions (subcortical, auditory [AUD], sensorimotor [SM], visuospatial 
      [VS], cognitive control [CC], and default mode network [DMN]). Static FC was 
      calculated as Fisher's z-transformed correlation coefficient. The sliding time 
      window correlation (window size 30 s, step size 3 s) was applied for dynamic FC, 
      and the standard deviation across sliding windows was calculated. Differences in 
      static and dynamic FC between EH and YH were calculated and compared by region. 
      RESULTS: EH showed decreased static FC in the subcortical, CC, and DMN regions 
      (FDR corrected p = 0.0013; 74 regions), with no regions showing static FC higher 
      than that in YH. EH showed increased dynamic FC in the subcortical, CC, and DMN 
      regions, whereas decreased dynamic FC in CC and DMN regions (p < 0.01). However, 
      the regions showing differences between EH and YH did not overlap between static 
      and dynamic FC. CONCLUSION: Dynamic FC exhibited differences from static FC in EH 
      and YH, mainly in regions involved in cognitive control and the DMN. Altered 
      dynamic FC demonstrated both qualitatively and quantitatively distinct patterns 
      of transient brain activity and needs to be studied as an imaging biomarker in 
      the aging process.
FAU - Park, Ji Eun
AU  - Park JE
AD  - Department of Radiology and Research Institute of Radiology, University of Ulsan 
      College of Medicine, Asan Medical Center, 86 Asanbyeongwon-Gil, Songpa-Gu, Seoul, 
      138-736, South Korea.
FAU - Jung, Seung Chai
AU  - Jung SC
AUID- ORCID: 0000-0001-5559-7973
AD  - Department of Radiology and Research Institute of Radiology, University of Ulsan 
      College of Medicine, Asan Medical Center, 86 Asanbyeongwon-Gil, Songpa-Gu, Seoul, 
      138-736, South Korea. dynamics79@gmail.com.
FAU - Ryu, Kyeoung Hwa
AU  - Ryu KH
AD  - Department of Radiology and Research Institute of Radiology, University of Ulsan 
      College of Medicine, Asan Medical Center, 86 Asanbyeongwon-Gil, Songpa-Gu, Seoul, 
      138-736, South Korea.
FAU - Oh, Joo Young
AU  - Oh JY
AD  - Department of Radiology and Research Institute of Radiology, University of Ulsan 
      College of Medicine, Asan Medical Center, 86 Asanbyeongwon-Gil, Songpa-Gu, Seoul, 
      138-736, South Korea.
FAU - Kim, Ho Sung
AU  - Kim HS
AD  - Department of Radiology and Research Institute of Radiology, University of Ulsan 
      College of Medicine, Asan Medical Center, 86 Asanbyeongwon-Gil, Songpa-Gu, Seoul, 
      138-736, South Korea.
FAU - Choi, Choong-Gon
AU  - Choi CG
AD  - Department of Radiology and Research Institute of Radiology, University of Ulsan 
      College of Medicine, Asan Medical Center, 86 Asanbyeongwon-Gil, Songpa-Gu, Seoul, 
      138-736, South Korea.
FAU - Kim, Sang Joon
AU  - Kim SJ
AD  - Department of Radiology and Research Institute of Radiology, University of Ulsan 
      College of Medicine, Asan Medical Center, 86 Asanbyeongwon-Gil, Songpa-Gu, Seoul, 
      138-736, South Korea.
FAU - Shim, Woo Hyun
AU  - Shim WH
AD  - Department of Radiology and Research Institute of Radiology, University of Ulsan 
      College of Medicine, Asan Medical Center, 86 Asanbyeongwon-Gil, Songpa-Gu, Seoul, 
      138-736, South Korea.
LA  - eng
PT  - Journal Article
DEP - 20170708
PL  - Germany
TA  - Neuroradiology
JT  - Neuroradiology
JID - 1302751
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain Mapping/*methods
MH  - Echo-Planar Imaging
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Neural Pathways/*diagnostic imaging
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Brain
OT  - Dynamic
OT  - Functional connectivity
OT  - Resting-state functional magnetic resonance imaging
OT  - Sliding window correlation
EDAT- 2017/07/10 06:00
MHDA- 2017/12/05 06:00
CRDT- 2017/07/10 06:00
PHST- 2017/02/27 00:00 [received]
PHST- 2017/06/28 00:00 [accepted]
PHST- 2017/07/10 06:00 [pubmed]
PHST- 2017/12/05 06:00 [medline]
PHST- 2017/07/10 06:00 [entrez]
AID - 10.1007/s00234-017-1875-2 [pii]
AID - 10.1007/s00234-017-1875-2 [doi]
PST - ppublish
SO  - Neuroradiology. 2017 Aug;59(8):781-789. doi: 10.1007/s00234-017-1875-2. Epub 2017 
      Jul 8.