PMID- 28689272
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20231214
IS  - 1880-6562 (Electronic)
IS  - 1880-6546 (Print)
IS  - 1880-6546 (Linking)
VI  - 68
IP  - 5
DP  - 2018 Sep
TI  - Insulin does not rescue cortical and trabecular bone loss in type 2 diabetic 
      Goto-Kakizaki rats.
PG  - 531-540
LID - 10.1007/s12576-017-0558-4 [doi]
AB  - In type 2 diabetes mellitus (T2DM), the decreased bone strength is often 
      associated with hyperglycemia and bone cell insulin resistance. Since T2DM is 
      increasingly reported in young adults, it is not known whether the effect of T2DM 
      on bone would be different in young adolescents and aging adults. Here, we found 
      shorter femoral and tibial lengths in 7-month, but not 13-month, Goto-Kakizaki 
      (GK) T2DM rats as compared to wild-type rats. Bone microCT analysis showed 
      long-lasting impairment of both cortical and trabecular bones in GK rats. 
      Although insulin treatment effectively improved hyperglycemia, it was not able to 
      rescue trabecular BMD and cortical thickness in young adult GK rats. In 
      conclusion, insulin treatment and alleviation of hyperglycemia did not increase 
      BMD of osteopenic GK rats. It is likely that early prevention of insulin 
      resistance should prevail over treatment of full-blown T2DM-related osteopathy.
FAU - Aeimlapa, Ratchaneevan
AU  - Aeimlapa R
AD  - Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, 
      Bangkok, 10400, Thailand.
AD  - Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol 
      University, Bangkok, Thailand.
FAU - Charoenphandhu, Narattaphol
AU  - Charoenphandhu N
AD  - Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, 
      Bangkok, 10400, Thailand. naratt@narattsys.com.
AD  - Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol 
      University, Bangkok, Thailand. naratt@narattsys.com.
AD  - Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand. 
      naratt@narattsys.com.
FAU - Suntornsaratoon, Panan
AU  - Suntornsaratoon P
AD  - Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, 
      Bangkok, 10400, Thailand.
AD  - Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol 
      University, Bangkok, Thailand.
FAU - Wongdee, Kannikar
AU  - Wongdee K
AD  - Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol 
      University, Bangkok, Thailand.
AD  - Office of Academic Management, Faculty of Allied Health Sciences, Burapha 
      University, Chonburi, Thailand.
FAU - Tiyasatkulkovit, Wacharaporn
AU  - Tiyasatkulkovit W
AD  - Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol 
      University, Bangkok, Thailand.
AD  - Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok, 
      Thailand.
FAU - Kengkoom, Kanchana
AU  - Kengkoom K
AD  - National Laboratory Animal Center, Mahidol University, Nakhon Pathom, Thailand.
FAU - Krishnamra, Nateetip
AU  - Krishnamra N
AD  - Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, 
      Bangkok, 10400, Thailand.
AD  - Center of Calcium and Bone Research (COCAB), Faculty of Science, Mahidol 
      University, Bangkok, Thailand.
LA  - eng
GR  - P-11-00639/Cluster and Program Management Office (CPMO), National Science and 
      Technology Development Agency/
GR  - RTA5780001/Thailand Research Fund/
GR  - IRN60W0001/Thailand Research Fund/
GR  - IRN60W0001/Thailand Research Fund/
GR  - -/Ministry of Science and Technology of Thailand/
GR  - -/Faculty of Science, Mahidol University/
GR  - 46/2560/Burapha University/
PT  - Journal Article
DEP - 20170708
PL  - Japan
TA  - J Physiol Sci
JT  - The journal of physiological sciences : JPS
JID - 101262417
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Bone Diseases, Metabolic/*prevention & control
MH  - Calcium/metabolism
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Female
MH  - Rats
MH  - Rats, Wistar
PMC - PMC10717542
OTO - NOTNLM
OT  - Blood glucose
OT  - Bone mineral density
OT  - Diabetes mellitus
OT  - Diabetic osteopathy
OT  - Goto-Kakizaki rats
COIS- The authors declare that there is no conflict of interest.
EDAT- 2017/07/10 06:00
MHDA- 2018/11/27 06:00
PMCR- 2017/07/08
CRDT- 2017/07/10 06:00
PHST- 2017/03/12 00:00 [received]
PHST- 2017/06/28 00:00 [accepted]
PHST- 2017/07/10 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
PHST- 2017/07/10 06:00 [entrez]
PHST- 2017/07/08 00:00 [pmc-release]
AID - 10.1007/s12576-017-0558-4 [pii]
AID - 558 [pii]
AID - 10.1007/s12576-017-0558-4 [doi]
PST - ppublish
SO  - J Physiol Sci. 2018 Sep;68(5):531-540. doi: 10.1007/s12576-017-0558-4. Epub 2017 
      Jul 8.