PMID- 2868969
OWN - NLM
STAT- MEDLINE
DCOM- 19860331
LR  - 20190824
IS  - 0306-3623 (Print)
IS  - 0306-3623 (Linking)
VI  - 17
IP  - 1
DP  - 1986
TI  - Pharmacology of amino acid receptors on vertebrate primary afferent nerve fibres.
PG  - 5-11
AB  - Structure-activity of primary afferent depolarising action (PAD) mediated by 
      gamma-aminobutyrate (GABA) analogues suggests a difference between subsynaptic 
      receptors located at fibre terminations within the dorsal horn and axonal 
      receptors which are distributed throughout non-synaptic regions. The interaction 
      of the bicuculline-sensitive GABA receptor (GABA A) ionophore complex with 
      barbiturates and benzodiazepines suggests that at least three binding sites are 
      required to explain the independent GABA-mimetic, GABA-potentiating and 
      picrotoxin-reversing effects of such agents. Difficulties with explanation of the 
      depressant effects of baclofen on spinal transmission, in terms of the 
      bicuculline-resistant GABA (GABA B) receptor hypothesis, are mentioned. 
      Glutamate-induced PAD of low threshold afferents is mediated indirectly through 
      release of potassium. However, such terminals possess receptors (possibly 
      autoreceptors for L-glutamate), activated by (+)2-amino-4-phosphonobutyrate, 
      which cause depression of transmitter release. Primary afferent C-fibres possess 
      receptors which are selectively activated by kainate and which mediate 
      picrotoxin-resistant PAD. Such receptors may be involved in the presynaptic 
      conditioning of C-fibre transmitter release. The peripheral terminals of 
      vestibular primary afferents, in amphibia, possess excitatory amino acid 
      receptors which are probably activated by the transmitter released from hair 
      cells.
FAU - Evans, R H
AU  - Evans RH
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Gen Pharmacol
JT  - General pharmacology
JID - 7602417
RN  - 0 (Barbiturates)
RN  - 0 (GABA Antagonists)
RN  - 0 (Glutamates)
RN  - 0 (Receptors, Amino Acid)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, GABA-A)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - H789N3FKE8 (Baclofen)
RN  - SIV03811UC (Kainic Acid)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - Animals
MH  - Baclofen/pharmacology
MH  - Barbiturates/pharmacology
MH  - Bicuculline/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - GABA Antagonists
MH  - Glutamates/pharmacology
MH  - Glutamic Acid
MH  - Humans
MH  - Kainic Acid/pharmacology
MH  - Neurons, Afferent/*drug effects
MH  - Receptors, Amino Acid
MH  - Receptors, Cell Surface/*drug effects
MH  - Receptors, GABA-A/*drug effects
MH  - Structure-Activity Relationship
MH  - gamma-Aminobutyric Acid/pharmacology
RF  - 84
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 0306-3623(86)90003-0 [pii]
AID - 10.1016/0306-3623(86)90003-0 [doi]
PST - ppublish
SO  - Gen Pharmacol. 1986;17(1):5-11. doi: 10.1016/0306-3623(86)90003-0.